Skin Repairing Peptides

Skin Repairing Peptides

Skin can be damaged for many reasons, such as UV and sun exposure, harsh skin care ingredients, over-washing or over-exfoliating, and many other things we do daily. Once we damage the skin barrier, our skin becomes vulnerable to external influences and is unable to retain moisture.

Peptides are small proteins that penetrate the skin to moisturize it and help improve the skin barrier.

Beauty Peptides

Skin Repairing Mechanisms

Skin repairing refers to the outermost lipid skin barrier (figure 1), otherwise known as the stratum corneum. Specially, an important component of this barrier comes from antimicrobial peptides (AMPs), which are small peptides that are abundantly expressed in the skin. AMPs are produced in the deeper layers of the epidermis and transported to the stratum corneum, where they play a crucial role in the first line of defense against potential pathogens ^[1].

In details, in healthy skin, constitutive expression of AMPs from resident cells provides the first line of defense against invading pathogens. In response to infection or injury to the skin barrier, infiltrating cells provide high levels of AMPs, while resident keratinizing cells increase AMPs production. AMPs are subsequently involved in a range of functions, including direct killing of microbes, attraction of inflammatory cells, stimulation of chemokine production, angiogenesis, and wound repair ^{[1, 2]}.

Fig. 1 AMPs in skin repairing

As a leading provider of cosmetic raw materials, Alfa Chemistry can supply high-quality beauty peptides to cosmetic companies looking to create innovative skincare products. Contact us today to learn more about how we can help you achieve your skincare goals.

References

1. Clausen ML, Agner T. Antimicrobial Peptides, Infections and the Skin Barrier. Curr Probl Dermatol. 2016;49:38-46.
2. Nguyen HLT, Trujillo-Paez JV, Umehara Y, et al. Role of Antimicrobial Peptides in Skin Barrier Repair in Individuals with Atopic Dermatitis. Int J Mol Sci. 2020 Oct 14;21(20):7607.

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Skin Repairing Peptides

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