Product Focus: Welcome to Alfa Chemistry's Hyaluronic Acid Series

Hyaluronic Acid (HA), a naturally occurring glycosaminoglycan, is a key component of the extracellular matrix found in various tissues throughout the human body, including skin, connective tissues, and joints. Its unique properties, such as high water-binding capacity and biocompatibility, make it a versatile biomaterial with a wide range of applications in various industries, including cosmetics, pharmaceuticals, and biotechnology.

Alfa Chemistry: Your Trusted Source for High-Quality Hyaluronic Acid!

At Alfa Chemistry, we specialize in providing high-quality hyaluronic acid raw materials in a variety of types, molecular weights, and specifications to meet the diverse needs of our clients.

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Structural Basis of Hyaluronic Acid

Hyaluronic acid has attracted much attention for its excellent moisturizing ability. It can absorb 1000 times its own weight in water, so it is known as a "super moisturizer". So, what makes hyaluronic acid so special? The answer is its structural basis!

The structure of hyaluronic acid is composed of repeating disaccharide units, which include N-acetylglucosamine (GlcNAc) and D-glucuronic acid (GlcA). These disaccharide units are alternately connected by β-1,3-glycosidic bonds and β-1,4-glycosidic bonds to form a linear polymer.

We can see that there are a lot of hydroxyl groups on its molecular chain, which are -OH bonds. They can combine with the H bonds in water molecules to form a huge net that locks moisture firmly. This is why it has a strong moisturizing ability.

Hyaluronic Acid Product Lines of Alfa Chemistry

Our extensive product line covers various types of hyaluronic acid, including:

By Molecular Weight

Low Molecular Weight Hyaluronic Acid

10kDa-500kDa

Penetration and absorption rate, long term moisturizing of the stratum corneum, excellent for skin renewal and joint maintenance.

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High Molecular Weight Hyaluronic Acid

>2000kDa

Water soluble solution, highly viscous, well cohesion and film-forming, used for most shaping and filling products, long metabolism time in the body.

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Medium Molecular Weight Hyaluronic Acid

500kDa-2000kDa

Penetrating and moisturizing, multipurpose.

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Oligomeric Hyaluronic Acid

<10kDa

Highly absorbable, penetrates into the skin for intense moisturizing, also works to scavenge free radicals and repair cell damage.

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Modified by Structure

Sodium Hyaluronate

Sodium salt of hyaluronic acid, more stable in nature and stronger in penetration, is the most common type in the cosmetic ingredient list.

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Acetylated Sodium Hyaluronate

Hyaluronic acid that has undergone acetylation. The addition of acetyl groups makes hyaluronic acid both hydrophilic and lipophilic.

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Hyaluronic Acid Cross-Linked Polymer

Ultra-high molecular weight polymer obtained by cross-linking of hyaluronic acid. It can form a breathable film on the surface of the skin, which plays a role in locking in moisture and moisturizing.

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Hydrolyzed Sodium Hyaluronate

High molecular weight hyaluronic acid is decomposed by enzymes to form low molecular weight hyaluronic acid. It can quickly penetrate the skin, lock in moisture deeply, and repair the base of the skin.

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Application of Hyaluronic Acid: Beyond Cosmetics

Entering the 21st century, the application of hyaluronic acid is no longer limited to the field of cosmetics, but has expanded to more comprehensive applications: such as ophthalmology, orthopedics, medical beauty, food, etc.

	Medical Field	Daily Chemical Products	Food Additives	Pet Food Products
Application Field	Mature applications: ophthalmology, orthopedics, surgery, minimally invasive medical cosmetology, otolaryngology, stomatology. New applications: dermatology, reproductive medicine. Frontier applications: tissue engineering, drug carriers, radiotherapy assistance, bone regeneration.	Mature applications: functional skin care products, body and head care products. New applications: makeup/foundation, toothpaste, disinfectant, etc.	New applications: health food additives, general food additives.	New applications: pet food, pet toiletries.
Typical Application Products	Hyaluronic acid viscoelastic, eye drops, injection, Gel; Hyaluronic acid microparticles, microneedles, powder, repair/protective film; Hyaluronic acid lubricant.	Hyaluronic acid stock solution, facial mask, eye cream, face cream, lotion, eye mask; Hyaluronic acid facial cleanser, shower gel, shampoo, conditioner, toothpaste, wash-free disinfectant; Hyaluronic acid foundation, isolation cream, lipstick.	Hyaluronic acid oral liquid, capsules, tablets, granules; Hyaluronic acid snacks, candies, beverages, milk and dairy products, alcohol, etc.	Pet functional staple food, snacks, health products containing hyaluronic acid; Pet bath gel and hair conditioner containing hyaluronic acid, etc.

What Our Clients Say

As a small indie brand, finding a reliable supplier of high-quality ingredients at a competitive price is crucial. Alfa Chemistry has exceeded our expectations. Furthermore, the team at Alfa Chemistry has provided us with excellent support and rapid responses to our inquiries. I highly recommend their products for anyone serious about delivering superior skincare solutions.

Ms. Jessica Li

Formulator, Indie Beauty Brand

We are always looking for innovative ingredients that can provide effective skin care solutions for our customers. Our relationship with Alfa Chemistry has been very good. Their combination of hyaluronic acids works really well - low molecular weight for absorption to high molecular weight for surface absorption we can make really good moisturizing ingredients. Alfa Chemistry has become a trusted supplier for our team.

Mr. Mark Ramirez

Head of R&D, Skincare Manufacturer

We recently added Alfa Chemistry's hyaluronic acid to our experimental moisturizer, and the test results were very good. We will use the hyaluronic acid they provided for further formulation development and efficacy evaluation. We are confident in the success of our formulation development thanks to Alfa Chemistry's reliable supply.

Dr. Sarah Thompson

Cosmetic Chemist, Beauty Labs

Why Choose Alfa Chemistry's Hyaluronic Acids

High Purity

Our HA products undergo rigorous quality control to ensure high purity and consistency.

Wide Range of Grades

We offer a diverse selection of HA grades to meet specific application requirements.

Competitive Pricing

We provide competitive pricing without compromising on quality.

Excellent Customer Support

Our team of experts is available to provide technical support and answer any questions you may have.

FAQs About Hyaluronic Acids

Is a smaller molecular weight of hyaluronic acid always better?

You should consider the different properties of molecular weights when you are creating formula with hyaluronic acid. If you're looking for the best moisturizing and soothing properties, using a blend of different molecular weights can be better than just low or high molecular weight HA. The approach of this strategy has led to the development of products marketed as 4D hyaluronic acid and 5D hyaluronic acid.

What are 4D and 5D hyaluronic acid?

The "D" in 4D and 5D refers to "dimension," representing the various combinations of hyaluronic acid used. Typical formulations include 4D, 5D, and even 6D hyaluronic acid, which incorporate a mix of super-large, large, medium, small, and micro molecules, as well as acetylated and silanized forms of hyaluronic acid. The designation of 4D denotes the inclusion of four distinct molecular types, while 5D encompasses five, and so forth. Currently, hyaluronic acid formulations have even evolved to include 9D variations.

Is the higher the concentration of hyaluronic acid, the better? What is the recommended concentration?

Hyaluronic acid is a typical ingredient that can be highly effective with a small amount of addition. Generally, the recommended concentration of hyaluronic acid ranges from 0.02% to 0.5%. When the concentration reaches around 2%, the substance behaves more like a gel and loses fluidity, becoming similar to glue in consistency. It's worth noting that 100% hyaluronic acid is typically found in powder form. As such, pursuing excessively high concentrations is unnecessary. The key lies in the right combination of molecular weights and concentrations for the intended formulation.

Cutting-Edge Case Study of Hyaluronic Acids

Hyaluronic Acid for Regenerative Medicine

Puertas-Bartolomé et al. prepared hydrogel bioink using a reactive hybrid bioprinting method to produce 3D scaffolds made of carboxymethyl chitosan and sodium hyaluronate (Mw ~ 1.5–1.8 × 106 Da) and containing catechol-functionalized polymer NPs loaded with coumarin-6. In vitro studies showed that the bio-printed scaffolds supported the viability and proliferation of encapsulated L929 fibroblasts over 14 days, indicating that this bioink may be a promising material for skin tissue regeneration processes. [1,2]

Cross-Linked Hyaluronic Acid Dry Gel Film Loaded with Salicylic Acid

The work of Anastasia Maria Mamaligka et al. evaluated the loading potential of SA in cross-linked HA dry gels and explored the integrity of the film during loading or swelling in SA aqueous solutions over a wide pH range. It was found that at pH 2.1, drug loading with cross-linked HA was promising, with a SA concentration of 28% w/w in the dry gel film. [3]

Contact & Ordering

Want to contact us or place an order? Just fill in the form below! We look forward to helping you make the most of hyaluronic acids in your formulations.

References

Carton, Flavia, et al. International Journal of Molecular Sciences, 2024, 25(7), 3975.
Puertas-Bartolomé, María, et al. Materials Science and Engineering: C, 2021, 131, 112515.
Mamaligka, Anastasia Maria, et al. Gels, 2024, 10(1), 54.