PDRN (Polydeoxyribonucleotide)
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General Information
- Product Name: PDRN (Polydeoxyribonucleotide)
- Trade Name: Sodium DNA
- Grade: Cosmetic Grade
- Catalog: CI-PD-001
- Applications: PDRN has the effects of repairing tissue, promoting wound healing and reducing inflammation, so it is widely used in mesotherapy, fillers and intra-articular injections.
Product Description
PDRN originates from reproductive cells of salmon or chum salmon where it contains both 50% double-stranded and 90% single-stranded deoxyribonucleotides and shows a 98% sequence similarity to human DNA bases.
Clinical evidence demonstrates that PDRN displays minimal immune response and toxicity alongside negligible human body side effects like rejection and allergic reactions. Medical research has proven that PDRN is a compound that promotes tissue repair, diminishes inflammation levels and activates cell regeneration mechanisms.
We produce our PDRN by extracting it from salmon sperm DNA and subjecting it to a controlled purification followed by sterilization procedures. Alfa Chemistry produces PDRN which serves multiple fields such as regenerative medicine, dermatology and aesthetics while maintaining strict quality standards to guarantee reliable performance in research and commercial applications.
- High Purity
- Wide Molecular Weight Range
- Biocompatible Sourcing & Controlled Stability
Product Specifications
| Items | Specification |
|---|
| Grade | Cosmetic Grade |
| Appearance | White powder |
| Molecular Weight | 50 - 1,500 kDa (size-exclusion chromatography) |
| Source | Salmon sperm (or alternative sources upon request) |
| Recommended usage | 0.5%-2% |
| Purity | 99% |
| Test | HPLC/UV |
| Applications | Mesotherapy and dermal-fillers |
| Packaging | Customizable |
| Hot Tags | PDRN for cosmetics, for human nutritional, food supplements. |
Action Mechanism of PDRN
PDRN exerts its therapeutic effects through multiple interconnected pathways, including:
Skin aging process and PDRN mechanism of action. [1]
Adenosine A2A Receptor Activation
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PDRN binds to adenosine A2A receptors, modulating inflammatory responses, apoptosis, and tissue repair.
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Activation inhibits ROS-triggered NF-κB and MAPK signaling pathways, suppressing pro-inflammatory cytokines (e.g., TNF-α, IL-12) and enhancing anti-inflammatory cytokines (e.g., IL-10).
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Increased cAMP levels via A2A activation further block MAPK pathways, reducing oxidative stress and promoting healing.
Collagen Synthesis
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A2A receptor stimulation downregulates Fli1, a transcriptional repressor of collagen genes, while upregulating connective tissue growth factor (CTGF).
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This cascade enhances collagen production in fibroblasts, validated by dose-dependent increases in collagen synthesis. Neutralizing CTGF abolishes this effect, confirming its role.
Anti-Inflammatory Effects
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PDRN suppresses pro-inflammatory mediators (COX-2, IL-1β, IL-6, TNF-α) and elevates anti-inflammatory IL-10 in macrophages and chondrocytes.
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Reduces apoptosis by lowering the Bax/Bcl-2 ratio, observed in models of colitis, arthritis, and lung injury.
Angiogenesis Enhancement
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PDRN boosts vascular endothelial growth factor (VEGF) expression via A2A receptors, promoting blood vessel formation (CD31, angiopoietin markers).
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Demonstrated efficacy in ischemic models (e.g., femoral artery occlusion, burn wounds), with effects blocked by A2A antagonist DMPX.
Melanogenesis Inhibition
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Downregulates MITF (melanogenesis regulator) and suppresses tyrosinase activity (key enzyme in melanin synthesis).
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Reduces expression of melanogenic proteins (TRP-1, TRP-2), lowering melanin production in melanocytes.
Frequently Asked Questions
Q1: Is PDRN safe for human use?
A: Yes. PDRN demonstrates biocompatibility and non-immunogenic properties with extensive clinical testing confirming its safe use.
Q2: How does PDRN differ from generic DNA extracts?
A: Stringent purification processes remove proteins and contaminants from PDRN to secure both optimal bioactivity and regulatory compliance.
Q3: Is it possible to mix PDRN with additional active ingredients such as hyaluronic acid?
A: Absolutely. PDRN works well with many medical and cosmetic products by strengthening combined results.
Q4: What is the recommended dosage for topical products?
A: Typical concentrations range from 0.5% to 2% (w/v), depending on the application. Consult our technical team for protocol optimization.
Reference
- Khan, Aawrish, et al. Chinese Journal of Plastic and Reconstructive Surgery, 2022, 4(4), 187-193.
