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| Catalog Number | CI-BP-0140 |
| Product Name | Biotinoyl Tripeptide-1 |
| CAS | 299157-54-3 |
| Structure |  |
| Synonyms | Biotinyl tripeptide-1,Boc-GHK |
| IUPAC Name | (5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)glycyl-L-histidyl-L-lysine |
| Molecular Weight | 566.67 g/mol |
| Molecular Formula | C24H38N8O6S |
| InChI | WCKVVODUWGBPQV-SOADLSRISA-N |
| InChI Key | InChI=1S/C24H38N8O6S/c25-8-4-3-5-15(23(36)37)30-22(35)16(9-14-10-26-13-28-14)29-20(34)11-27-19(33)7-2-1-6-18-21-17(12-39-18)31-24(38)32-21/h10,13,15-18,21H,1-9,11-12,25H2,(H,26,28)(H,27,33)(H,29,34)(H,30,35)(H,36,37)(H2,31,32,38)/t15-,16-,17-,18-,21-/m0/s1 |
| Boiling Point | Wrinkle smoothing and skin relaxing |
| Purity | 95% by HPLC |
| Appearance | Lyophilized powder |
| Application | This product can be used to conduct research on dermal wound healing. |
| Storage | Keep in dark and cool dry place -5~8°C |
| Isomeric SMILES | NCCCC[C@@H](C(O)=O)NC([C@H](CC1=CNC=N1)NC(CNC(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O)=O)=O |
Biotinoyl Tripeptide-1 is utilized for its ability to combat premature hair loss by enhancing the vitality of hair follicles. It stimulates cellular communication and metabolism, thereby supporting anti-aging processes within the follicle. This vitamin-enriched tripeptide complex, which contains Vitamin B7, targets primary causes of alopecia by mitigating the effects of harmful dihydrotestosterone (DHT) and improving follicular blood flow. Additionally, it stimulates the production of anchoring molecules and promotes hair growth by up to 121%, addressing a condition that can affect a significant portion of both Caucasian men and women throughout their lifetimes.
What is Biotinoyl Tripeptide-1, and how does it work to reduce hair loss?
Biotinoyl Tripeptide-1 is a derivative of the peptide Gly-His-Lys combined with biotin, also known as Vitamin B7. It works by addressing several underlying causes of hair loss, including high levels of dihydrotestosterone (DHT), insufficient blood supply to the scalp, and the degradation of structural components like collagen IV and laminin 5. Biotinoyl Tripeptide-1 helps improve the morphology of the hair follicle, enhances the anchor strength of hair, and increases the anagen to telogen phase ratio which reduces hair loss.
How effective is Biotinoyl Tripeptide-1 in preventing hair loss?
Biotinoyl Tripeptide-1 has been tested in vitro and in clinical trials and has shown morphological improvements in the hair follicle, increased follicle growth, and preservation of structural proteins like laminin 5 and collagen IV. These results indicate a significant reduction in the rate of hair loss among men.
What makes Biotinoyl Tripeptide-1 beneficial for hair compared to other treatments?
Biotinoyl Tripeptide-1 provides the dual advantage of biotin, which is essential for hair health, and the targeted action of the tripeptide, which enhances keratinocyte proliferation, improves blood supply, and strengthens the epithelial sheath. This combination makes it a potent anti-hair loss ingredient.
Can Biotinoyl Tripeptide-1 be combined with other active ingredients?
Yes, Biotinoyl Tripeptide-1 can be effectively combined with other active skincare ingredients like Red Clover Extract, Biochanin A and Acetyl Tetrapeptide-3 to enhance its anti-hair loss effects.
Are there any studies to support the effects of Biotinoyl Tripeptide-1 on hair follicles?
Yes, studies including in vitro culture of human hair follicles treated with Biotinoyl Tripeptide-1 showed increased growth, preserved structural protein layers, and upregulation of adhesion complex proteins and cell proliferation regulatory proteins by up to 90%. These findings support its role in promoting hair growth and anchoring.
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