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| Catalog Number | CI-SC-0734 |
| Product Name | Vitamin C (sodium ascorbyl phosphate) |
| CAS | 66170-10-3 |
| Structure |  |
| Description | Sodium ascorbyl phosphate (SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. Light-stable and oxygen-stable. Purity >95.0%. Ascorbic acid content at least 45%. May discolor at pH levels below 6. |
| Solubility | Soluble in water (clear solution at 3% concentration) |
| Appearance | White-to off-white powder, mild characteristic odor |
| Application | Lotions, creams, sun care & after sun products, makeup products. |
| Storage | Store light-protected at a cool and dry place |
| Composition | Sodium ascorbyl phosphate |
| Features And Benefits | Stabilized form of vitamin C that does not degrade in aqueous formulas. Esterification of asorbic acid protects vitamin C from oxidative degradation.Potent antioxidant (shown to be able to protect skin from oxidative damages)Can improve appearance of aged and fragile skinWidely used as add-on ingredient in skin-lightening products to correct hyperpigmentation and age spotsAntioxidant effect can be increased by adding L-ascorbyl palmitate and/or vitamin E. |
| GMO | GMO-free (does not contain plant-derived components) |
| HS Code | 2936270000 |
| INCI | Sodium ascorbyl phosphate |
| Manufacture | Sodium ascorbyl phosphate is produced by direct phosphorylation of ascorbic acid sodium salt where l-ascorbic acid is suspended in an oxygenated, non-hydroxylic solvent together with sodium and then treated with a phosphorylating agent. |
| Preservation | Preservative-free |
| Purity Grade | No purity grade applicable |
| Raw Material Source | L-ascorbic acid, sodium, and phosphoryl chloride (or other phosphorylating agents) |
| Uses | Add at the end of the formulation process just before the preservative, by pre-dissolving in a little distilled water. Typical use level 0.2-3%, but up to 10%. For external use only. |
Sodium ascorbyl phosphate (SAP), a stable form of vitamin C, is utilized in skincare formulations due to its effectiveness and stability compared to traditional ascorbic acid. As a derivative of vitamin C, SAP is recognized for its antioxidant properties, playing a crucial role in neutralizing free radicals and supporting collagen synthesis, which can mitigate the signs of photoaging. Its stability in aqueous solutions overcomes the typical challenges associated with vitamin C's oxidation, making it an ideal ingredient in cosmetics. Moreover, SAP enhances the antioxidant function of Vitamin E, further contributing to its efficacy in skincare products. When applied to the skin, SAP is converted to biologically active L-ascorbic acid by phosphatase enzymes, enabling its use as a potent ingredient in enhancing skin health and appearance.
Ruamrak, C., N. Lourith, et al. International journal of cosmetic science, 2009, 31(1), 41-46.
This randomized, double-blind study compared the efficacy of a topical formulation containing sodium ascorbyl phosphate (SAP) 5% and retinol 0.2% alone and in combination. The results indicate that the combination of SAP and retinol significantly reduced inflammatory lesions compared with use alone and can be used to effectively treat acne vulgaris.
Experimental design and results
· The study involved 45 participants with grade II-III facial acne. They were randomly divided into three groups: 15 used a 5% SAP lotion with a control base cream, 15 used a 0.2% retinol cream with a control base lotion, and 15 used both the 5% SAP lotion and the 0.2% retinol cream. Those using the SAP lotion applied it twice daily for 8 weeks to all facial areas, while the retinol cream was applied only at night. Participants in the combination group applied the SAP lotion twice daily and the retinol cream once daily, following the same guidelines as the separate treatments.
· Results indicated that the SAP lotion reduced inflammatory lesions by 20.14% in 4 weeks and 48.82% in 8 weeks. The retinol cream showed a slight improvement, with lesions decreasing by 21.79% after 4 weeks and 49.50% after 8 weeks. The combination treatment was more effective, leading to a 29.28% reduction after 4 weeks and 63.10% after 8 weeks of use.
Alma Fočo, et al. International Journal of Pharmaceutics, 2005, 291(1-2), 21-29.
A liposome-encapsulated sodium ascorbyl phosphate (SAP) formulation was developed to improve its ability to penetrate the stratum corneum into the deeper layers of the skin. Two multilamellar vesicles were prepared by the thin film method, and their upper limit of SAP encapsulation efficiency was 8-10%. The study showed that the liposome carrier enabled greater penetration of SAP through the epidermal membrane compared to application of SAP in aqueous solution to the skin surface. SAP that penetrates the epidermis reflects active compounds, which can slow down the complex process of skin phototoxicity.
Preparation of liposome-encapsulated SAP
· Multilamellar vesicles (MLVs) were constructed using non-hydrogenated (NS) or hydrogenated (HS) soybean lecithin combined with 30% (w/w) cholesterol, utilizing the thin film technique. The organic solvent was removed through evaporation, and any remaining solvent traces were eliminated by subjecting the lipid films to a vacuum overnight.
· SAP was incorporated into the liposomes during the hydration process at concentrations of 1% and 2%. This hydration was carried out at temperatures above the phase transition temperature (Tm) of the phospholipids, which is 23 °C for NS and 80 °C for HS.
· The liposome dispersions were then reduced in size through sonication, with a sonication time of 150 seconds at an amplitude of 35%.
What is sodium ascorbyl phosphate?
Sodium ascorbyl phosphate is a stable, water-soluble form of vitamin C made from combining ascorbic acid with a phosphate and a salt.
How does sodium ascorbyl phosphate function on and within the skin?
Sodium ascorbyl phosphate functions as an antioxidant on and within the skin.
What are the benefits of using sodium ascorbyl phosphate on the skin?
Sodium ascorbyl phosphate can brighten a dull skin tone, smooth wrinkles, visibly firm skin, reduce discolorations, fight free radicals, boost collagen production, even out skin tone, and have anti-acne benefits.
What is the usual concentration of sodium ascorbyl phosphate in skin care products?
The usual concentration of sodium ascorbyl phosphate in skin care ranges from 0.2-3%.
How does sodium ascorbyl phosphate compare to ascorbic acid in terms of wrinkle-smoothing and elasticity-increasing benefits?
A 5% concentration of sodium ascorbyl phosphate was shown to have equivalent wrinkle-smoothing and elasticity-increasing benefits as the same amount of ascorbic acid in a comparative study.
What concentrations of sodium ascorbyl phosphate have been shown to influence factors linked to breakouts?
Both 1% and 5% concentrations of sodium ascorbyl phosphate have been shown to influence factors linked to breakouts.
Is sodium ascorbyl phosphate safe to use in skin care products?
Yes, sodium ascorbyl phosphate is considered safe to use in skin care products.
What can weaken the efficacy of sodium ascorbyl phosphate over time?
Ongoing exposure to light and air can weaken the efficacy of sodium ascorbyl phosphate over time, although not as quickly as pure ascorbic acid.
Can sodium ascorbyl phosphate be used by all skin types?
Sodium ascorbyl phosphate is generally safe for all skin types, although some people may experience mild irritation.
What ingredients work well with sodium ascorbyl phosphate?
Other antioxidants, such as vitamin E and ferulic acid, as well as hydrating ingredients like hyaluronic acid, work well with sodium ascorbyl phosphate.
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