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Tripeptide-1

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Catalog Number CI-BP-0068
Product Name Tripeptide-1
CAS 72957-37-0
Structure
Synonyms N2-(N-glycyl-L-histidyl)-L-lysine monoacetate
IUPAC Name acetic acid;(2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid
Molecular Weight 400.44 g/mol
Molecular Formula C16H28N6O6
InChI InChI=1S/C14H24N6O4.C2H4O2/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9;1-2(3)4/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24);1H3,(H,3,4)/t10-,11-;/m0./s1
InChI Key MGNUTAFMLGJBGV-ACMTZBLWSA-N
Purity 0.95
Appearance White powder
Storage -15~-20 °C
Isomeric SMILES CC(=O)O.C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)CN
Safety No heavy metals, no skin and eye irritation
Product Overview

Tripeptide-1, also known as GHK peptide and a fragment of collagen type I, is an innovative compound designed to combat visible signs of premature aging. It functions as a signaling peptide, encouraging the production of essential extracellular matrix components such as collagen, hyaluronic acid, and glycosaminoglycans, thereby reducing the appearance of fine lines and wrinkles. This peptide protects and stabilizes collagen fibers, preserving their native structure and combatting age-related wrinkles. Tripeptide-1 also exhibits a strong anti-collagenase effect, preventing enzymatic degradation of collagen fibers and supporting the skin's structural integrity. Collaborations with the University of Milan revealed that Tripeptide-1 is the first cosmetic ingredient capable of detoxifying the skin from newly identified reactive carbonyl species, harmful free radicals linked to aging and pollution. It efficiently detoxifies cells, maintaining their health and protecting against free radical damage and collagen elasticity loss. Laboratory tests show a remarkable 97% protection of DNA from UVA-induced damage, underscoring its effectiveness against photo-aging. This versatile peptide also serves as a foundational molecule for developing specialized products, such as Biotinoyl Tripeptide-1 for hair, brow, and eyelash care, and Palmitoyl Tripeptide-1 for premium skincare formulations.

Custom Q&A

What is Tripeptide-1, and how does it benefit the skin?

Tripeptide-1, also known as GHK peptide, is a fragment of collagen type I and a significant molecular innovation in skincare. It actively helps prevent visible signs of premature aging by stimulating the synthesis of extracellular matrix components such as collagen, hyaluronic acid, and glycosaminoglycans (GAGs). By doing so, it decreases fine lines and wrinkles, protects and stabilizes collagen fibers, and prevents their enzymatic degradation, which fights against aging-derived wrinkles.

How does Tripeptide-1 protect the skin from environmental and sun damage?

Tripeptide-1 acts as an RCS (Reactive Carbonyl Species) scavenger, detoxifying the skin from harmful free radicals found in polluted air or photo-aged skin, which can cause collagen elasticity loss and damage. It offers 97% DNA protection, shielding the skin from UVA-induced damage and preventing the visible signs of photo-aging. Tripeptide-1 has been validated as the first cosmetic active ingredient that can effectively counteract the damage caused by these noxious reactive carbonyl species.

Can Tripeptide-1 be used in combination with other ingredients for enhanced skincare benefits?

Yes, Tripeptide-1 serves as a core molecule for developing specialized ingredients like Biotinoyl Tripeptide-1 for hair, brow, and eyelash care, and Palmitoyl Tripeptide-1 for advanced skincare products. Its multifunctional properties make it versatile and suitable for enhancing a variety of beauty and skincare formulations.

Is Tripeptide-1 effective against all signs of aging?

Tripeptide-1 primarily targets premature aging signs by protecting and enhancing collagen and related extracellular matrix components. While it effectively reduces fine lines and wrinkles and shields the skin from environmental damage, a comprehensive skincare routine including other active ingredients may be necessary for targeting specific aging concerns beyond those addressed by Tripeptide-1 alone.

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