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| Catalog Number | CI-HC-0131 |
| Product Name | Sucrose Cocoate |
| CAS | 91031-88-8 |
| Synonyms | Fattyacid,coco,esterswithsucrose;SUCROSE COCOATE;Fatty acids, coco, esters with sucrose ;Fettsuren, Kokos-, Ester mit Sucrose |
| Description | Natural, PEG-free, hydrophilic emollient and moisturizer made of sucrose esters of coconut fatty acid (sugar beets and coconut oil). HLB 15. |
| Solubility | Dispersible in water |
| Appearance | White to slightly yellowish paste |
| Application | Hair & body & face cleansing formulations (especially for very mild products), as moisturizer & emollient in creams & lotions. |
| Storage | Store in a closed container at a dry place at room temperature |
| Composition | Sucrose cocoate |
| Features And Benefits | Provides pleasant re-fatting and emollient effectsEffective moisturizerIncreases foam density, viscosity and mildness of cleansing productsIncreases gentleness and creaminess of creams & lotionsHas mild thickening effect |
| GMO | GMO-free |
| HS Code | 3823706000 |
| INCI | Sucrose cocoate |
| Manufacture | Sucrose cocoate is produced from sucrose and the methyl and ethyl esters of coconut-derived fatty acids in the presence of a solvent. |
| Preservation | Preservative-free |
| Purity Grade | No purity grade applicable |
| Raw Material Source | Sucrose (table sugar) and coconut oil |
| Uses | Use level 2-4% in cleansing formulas, 3 5% in emulsions (creams, lotions). For better processing you may heat it to 104-140°F (40-60°C). Add to water phase of formulas. For external use only. |
Tavano, Lorena, et al. Colloids and Surfaces B: Biointerfaces, 2010, 75(1), 319-322.
The sucrose cocoate surfactant enabled the creation of a vesicular system suitable for transdermal drug delivery. Sucrose cocoate was found to form vesicles in the presence or absence of cholesterol, and the addition of cholesterol resulted in a change in vesicle size: The absence of cholesterol led to bigger vesicles for both empty and drug-loaded types. The vesicular formulation demonstrated potential for transdermal drug delivery as well as improved drug release from the carrier due to its increased percutaneous permeability through rabbit skin compared to the control drug solution. A cholesterol concentration of around 27wt% of the total lipid mass produced an optimal formulation.
Sucrose Cocoate-Based Vesicle Preparation
Sucrose cocoate and cholesterol were combined in various weight ratios and dissolved in hexane. After vacuum evaporation removed the organic solvent the resultant lipid film remained under vacuum at room temperature for 24 hours to dry. The film was then hydrated with 10 ml of a drug solution (2 × 10^-3 M) while stirring mechanically at 50°C for 30 minutes. Small unilamellar vesicles (SUV) were formed from multilamellar vesicles (MLV) through sonication in an ultrasonic bath for 30 minutes at 50°C. Following this, the dispersion was left at room temperature overnight to enable complete annealing and drug partitioning between the lipid bilayer and the aqueous phase. The niosomes were further purified by extensive dialysis for 6 hours using Visking tubing (20/30).
Ahsan, Fakhrul, et al. International journal of pharmaceutics, 2003, 251(1-2), 195-203.
Sucrose cocoate is an emulsifier used in emollient, moisturizing cosmetic formulations. This study measured the effect of sucrose cocoate on the absorption of two different peptide drugs (insulin and calcitonin) after nasal and ocular administration via Dawley male rats.
· Preparation of Nasal and Ocular Formulations
Solutions of sucrose cocoate in normal saline were prepared at a 1% (w/v) concentration on the day of the experiment. The nasal and ocular formulations resulted from mixing standard human insulin (100 U/ml) or salmon calcitonin (2200 U/ml) with calculated amounts of sucrose cocoate and saline to achieve 25 U/ml insulin or 110 U/ml calcitonin in the final blend.
· Key Findings
The administration of a nasal formulation of insulin with 0.5% sucrose cocoate led to a rapid and significant rise in plasma insulin levels, accompanied by a decrease in blood glucose levels. When insulin was delivered ocularly with the same concentration of sucrose cocoate, a smaller increase in plasma insulin and a reduction in blood glucose were noted. The nasal delivery of a calcitonin formulation, also containing 0.5% sucrose cocoate, rapidly elevated plasma calcitonin levels while lowering plasma calcium levels. In vivo studies demonstrated that this ester effectively enhanced the absorption of nasal peptide drugs.
What is sucrose cocoate made from?
Sucrose cocoate is made by combining sugar esters from coconut acid (fatty acids from coconut oil).
Is sucrose cocoate always derived from coconut?
No, synthetic forms of sucrose cocoate also exist.
What are the uses of sucrose cocoate?
Sucrose cocoate is used as a gentle surfactant, emulsifier, and emollient. It also improves foaming aesthetic when added to cleansers and improves the texture and spreadability of creams and lotions.
How is sucrose cocoate incorporated into different types of skin care formulas?
Sucrose cocoate is a water-loving liquid ingredient with a thick texture that is relatively easy to incorporate into different types of skin care formulas, both leave-on and rinse-off varieties.
What are the recommended amounts of sucrose cocoate to be used as a cleansing agent or to increase foam density?
Amounts between 2-4% are recommended to be used as a cleansing agent or to increase foam density.
What are the recommended amounts of sucrose cocoate to be used as emulsifiers and thickening agents in leave-on products?
Amounts between 3-5% are recommended to be used as emulsifiers and thickening agents in leave-on products.
Can sucrose cocoate be used in baby care products?
Yes, sucrose cocoate is considered gentle enough to use in baby care products such as shampoos and lotions.
What is the established safety concentration of sucrose cocoate in cosmetics?
The safety of sucrose cocoate in cosmetics has been established for concentrations as high as 20.6%.
What is SL-40?
SL-40 is an emulsifier that contains a mixture of sucrose esters of coconut fatty acids in aqueous ethanol solution.
What are some findings from absorption studies using sucrose cocoate?
Administration of a nasal insulin formulation containing 0.5% sucrose cocoate caused a rapid and significant increase in plasma insulin levels, with a concomitant decrease in blood glucose levels. When insulin was administered ocularly in the presence of 0.5% sucrose cocoate, a smaller increase in plasma insulin levels, and a decrease in blood glucose levels, were observed. Administration of a nasal calcitonin formulation containing 0.5% sucrose cocoate caused a rapid increase in plasma calcitonin levels and a concomitant decrease in plasma calcium levels.
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