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| Catalog Number | CI-OT-0009 |
| Product Name | Retinol |
| CAS | 11103-57-4 |
| Structure |  |
| Synonyms | Vitamin A1 |
| IUPAC Name | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol |
| Molecular Weight | 286.45 g/mol |
| Molecular Formula | C20H30O |
| InChI | InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ |
| InChI Key | FPIPGXGPPPQFEQ-OVSJKPMPSA-N |
| Purity | 98% |
| Appearance | Solid |
| Highest Usage In Residency Products | 0.01 |
| Isomeric SMILES | CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C |
Retinol, a potent form of vitamin A, is frequently utilized in skin care products due to its broad spectrum of benefits. When applied topically, retinol enhances skin elasticity promotes the thickening of the epidermis and dermis, and is instrumental in normalizing dry skin and reversing photodamage. It is also beneficial in reducing scalp scaliness and improving hair condition when incorporated into hair care formulations. However retinol's efficacy can be challenged by its inherent instability; it is sensitive to temperature, oxygen and light, which necessitates careful formulation and packaging strategies. These include adding antioxidants such as tocopherol and ascorbyl palmitate, ensuring an optimal pH level and using opaque packaging to mitigate exposure to environmental factors. Despite these challenges, retinol remains a preferred option for enhancing skin and hair health, provided that these stability considerations are carefully managed.
Wang, Yuan, et al. Scientific Reports, 2024, 14(1), 22793.
In order to break through the limitation of skin permeability of retinol, this work studied the transdermal behavior of two retinol-based cosmetic semisolid preparations through in vitro and in vivo experiments.
· Retinol semisolid preparation formula
Formula ROL-C1: water, acrylic acid (ester) copolymer sodium, carbomer, arginine, acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer; Pentaerythritol tetra (ethylhexanoate) ester, olive oil, caprylic acid / capric acid glycerides, polydimethylsiloxane, behenic alcohol, lecithin, hydrogenated lecithin, behenic acid.
Formula ROL-C2: Water, carbomer, arginine, acrylic acid (ester) copolymer sodium, acryloyl dimethyl taurine ammonium / behen alcohol polyether-25 methacrylate crosslinked polymer; Polydimethylsiloxane, PEG-9 polydimethylsiloxane, polydimethylsiloxane PEG-10 / 15 crosslinked polymer, lecithin, olive oil.
· Transdermal permeation mechanism and behavior
In the skin of the three animal models tested, retinol in semisolid cosmetics was mainly concentrated in the stratum corneum. Similar results were obtained in live mice and rats, where retinol did not cross the skin barrier and did not enter the blood circulation, which indicates that it can be used as a long-term daily.
In the skin of the three animal models tested, retinol in semisolid cosmetics was mainly concentrated in the stratum corneum. Similar results were obtained in live mice and rats, where retinol did not cross the skin barrier and did not enter the blood circulation, which indicates that it can be used as a long-term daily.
To explore the epidermal transport mechanism and intradermal retention, a skin transcriptomic study of rats was performed, identifying 126 upregulated genes related to retinol transport and metabolism (e.g., Stra6, Rdh12, and Lrat).
Pawłowska, Małgorzata, et al. International Journal of Molecular Sciences, 2024, 25(18),10078.
Solid lipid nanoparticles (SLNs) containing retinol and pentapeptide (Tyr-D-Ala-Gly-Phe-Leu) are a compatible combination of ingredients with broad anti-aging properties that can have a full range of effects on the skin. This work evaluated the stability of lipid nanocarriers containing retinol and peptides to verify the potential of the dispersion as a cosmetic raw material.
· Development of SLNs based on retinol and pentapeptide
SLNs were prepared using a high shear homogenization (HSH) method based on multiple emulsions (W/O/W). The qualitative composition of the SLN dispersion was optimized in detail, taking into account factors such as the type of solid lipids, surfactants, and the presence of liquid lipids in the lipid matrix. Ultimately, glyceryl monostearate was the most compatible as a solid lipid, the presence of L-phosphatidylcholine as a polar lipid compound also proved to be crucial for dispersion, and the surfactant group represented by the combination of Tween 80, sodium cholate, and CTAB proved to be the most effective.
· Performance of Retinol and Pentapeptide SLNs
The physicochemical parameters of the designed retinol and pentapeptide-rich SLNs, such as particle size (Z-Ave) < 200 nm, polydispersity index (PDI) up to 0.3 and zeta potential (ZP) >30 mV, were demonstrated. The efficiency of transepidermal transport of SLNs has been confirmed by in vivo studies, indicating the potential of these SLNs in reducing wrinkles and supporting regeneration of the delicate periocular skin.
What are the primary benefits of using Retinol for skin care?
Retinol activates fibroblasts, which enhances collagen production. This process thickens both the epidermis and dermis, effectively reducing wrinkles and fine lines. Additionally, Retinol is known for reversing photodamage and photoaging, which are caused by UV light reducing Vitamin A levels in the skin and activating collagenase that breaks down collagen in connective tissues.
How does Retinol interact with photodamaged skin?
Retinol treatment is particularly effective on photodamaged skin. It helps reverse the effects of photodamage by correcting Atrophy and Atypia, increasing the granular layer with larger granules, improving cell differentiation, and enlarging the intercellular spaces within the epidermis. This helps rejuvenate and restore the structure and appearance of damaged skin.
Can Retinol be considered a preventative ingredient against cancer?
Yes, Retinol can be considered a cancer preventative ingredient, particularly due to its role in combating squamous metaplasia. By assisting in the maintenance and function of mucous membranes, Retinol serves a protective role that may help in reducing cancer risks associated with mucous membrane disruptions.
Is Retinol effective in treating any specific conditions beyond general skin aging?
Beyond its anti-aging benefits, Retinol is also beneficial in the treatment of certain conditions such as senile vaginitis. It enhances the structure and function of mucous membranes, providing therapeutic advantages in vitamin A deficient states where mucous production is compromised.
How does Vitamin A deficiency affect the skin and how does Retinol help?
A deficiency in Vitamin A can lead to reduced mucous production and compromised mucous membrane function. Retinol replenishes Vitamin A levels, which is essential for maintaining the integrity of mucous membranes. It aids in the restoration of normal skin function and appearance, particularly in areas of deficiency.
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