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| Catalog Number | CI-SC-0989 |
| Product Name | Provitamin B5 (d-panthenol) |
| CAS | 81-13-0 / 7732-18-5 |
| Description | Provitamin B5 (synonyms: D-pantothenyl alcohol, pantothenol, dexpanthenol) is the alcohol analog of pantothenic acid (vitamin B5). Activity 75%. |
| Solubility | Soluble in water & alcohol, not in oils |
| Appearance | Clear viscous liquid, no or faint odor |
| Application | Creams, lotions, shampoos, conditioners, body washes, makeup. |
| Storage | Store light-protected at a cool and dry place |
| Composition | D-panthenol, water |
| Features And Benefits | Penetrates readily into skin & hairHas good moisturizing and softening propertiesSoothes irritated and blemished skinGives the hair moisture & shine and reduces split ends. |
| GMO | GMO-free (does not contain plant-derived components) |
| HS Code | 2936240100 |
| INCI | D-panthenol |
| Manufacture | Panthenol is synthetically produced by combining propanolamine and beta-dimethylbutyrolactone. |
| Preservation | Preservative-free |
| Purity Grade | No purity grade applicable |
| Raw Material Source | Propanolamine and beta-dimethylbutyrolactone |
| Uses | Add to cold or hot formulas, usual final concentration 0.5-5%. For external use only. |
Zhang, Xianghua, et al. Skin Research and Technology, 2024, 30(1), e13540.
A facial cream formulation containing provitamin B5, prebiotics and probiotic lysate was developed and its efficacy and safety as an optimal care for sensitive facial skin was evaluated by measuring indicators related to skin barrier function.
· Cream formula composition
The test cream, which contained provitamin B5 (panthenol), TRIBIOMA (ECOSKIN + Mannose), APF, hydroxyproline, zinc gluconate, manganese gluconate, hyaluronic acid and glycerin, was applied to the entire face twice daily for 28 days.
· Assessment results
After 28 days of use, the subjects' skin barrier function-related indicators were significantly improved, including increased stratum corneum moisture content, reduced erythema index, increased sebum content, reduced transepidermal water loss, and reduced skin redness parameter a* values (all p < 0.05). Furthermore, the evaluation showed that it was very well tolerated by all subjects.
Heise, R., et al. Skin pharmacology and physiology, 2012, 25(5), 241-248.
Here an in vivo study was performed analyzing the gene expression profile induced by dexpanthenol in skin punch biopsies that were injured and treated with provitamin B5 (dexpanthenol) compared to skin treated with placebo.
Evaluation methods and key results
· Three groups received different numbers of treatments to monitor the effects of dexpanthenol on gene expression at different stages of wound healing. A significant effect of dexpanthenol on gene regulation compared to placebo treatment could be shown in all samples at all three time points analyzed. In particular, in the second group (72 h after injury, receiving five dexpanthenol applications), upregulation of 95 genes following dexpanthenol treatment could be detected by gene chip analysis.
· The changes in gene expression following 3 days of topical dexpanthenol treatment included upregulation of IL-6, IL-1, CYP1B1, CXCL1, CCL2, CCR1, and CCL18 mRNA expression. Therefore, it is tempting to speculate that proliferating dermal fibroblasts are at least partly the source of the enhanced mRNA levels in injured skin tissue treated with dexpanthenol.
· Wound tissue treated with dexpanthenol (11 treatments over 144 hours) showed a significant reduction in the expression of psoriasin (S100 calcium-binding protein A7A) compared with placebo-treated skin wounds. This effect could be confirmed at the protein level in material from independent donors using immunohistochemistry.
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