Polyglyceryl-6 Laurate

Vukašinović, Mila, et al. Pharmaceutics, 2023, 15(2), 486.

There were 22 relatively simple oil-in-water emulsions that were made by a time/energy-saving emulsification. A natural blend of emulsifiers (Lauryl Glucoside/Myristyl Glucoside/Polyglyceryl-6 Laurate) and two emollients (INCI names both C15-19 Alkanes) are used. Furthermore, response surface methodology (RSM) optimal experimental design studies showed that the tested formulation factors (emulsifier concentration and emollient concentration and type) individually and interactively have a significant impact on the physicochemical properties, especially the rheological properties.
Preparation of emulsion samples
· All emulsions, both in type and concentration of emollient and in concentration of emulsifier, were cold emulsified at room temperature.
· Nonionic O/W emulsifier (2% or 3% w/w lauryl glucoside/myristyl glucoside/polyglyceryl-6 laurate mixture) was added to the aqueous phase, and then homogenised at 6000 rpm for 40 seconds.
· The oil phase (10%, 20%, or 30% w/w of single emollient (light liquid paraffin, Emogreen L15, Emogreen L19) was added slowly to the aqueous phase and homogenized at 4400 rpm.
· The resulting emulsion was further homogenized for 5 minutes at 8000 rpm. In the final minute of homogenization, 1% w/w preservative was added. The emulsion was then transferred to a laboratory stirrer equipped with a propeller mixing tool, where xanthan gum dispersed in glycerin was incorporated at 650 rpm for 6 minutes.