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| Catalog Number | CI-SC-1229 |
| Product Name | Phytosphingosine |
| CAS | 13552-11-9 |
| Structure |  |
| Synonyms | 3,4-Octadecanetriol, 2-amino-1 |
| IUPAC Name | 2-aminooctadecane-1,3,4-triol |
| Molecular Weight | 317.5 g/mol |
| Molecular Formula | C18H39NO3 |
| InChI | InChI=1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3 |
| InChI Key | AERBNCYCJBRYDG-UHFFFAOYSA-N |
| Boiling Point | 483.5±40.0 °C |
| Melting Point | 136-138 °C |
| Purity | 95% |
| Density | 0.98 g/mL |
| Appearance | Solid |
| Highest Usage In Residency Products | 0.02 |
| Isomeric SMILES | CCCCCCCCCCCCCCC(C(C(CO)N)O)O |
Phytosphingosine, a plant-derived sphingosine and a fundamental component of ceramides, plays a vital role in skin health. As a member of sphingoid bases, it is abundantly present in the stratum corneum, contributing significantly to the skin's defense system by inhibiting microbial growth. Biotechnologically obtained through the fermentation of yeast, particularly Pichia ciferrii, phytosphingosine exhibits outstanding antimicrobial and anti-inflammatory properties. These characteristics make it especially effective in managing skin conditions such as acne and inflammation associated with microbial imbalance. By enhancing skin repair and reinforcing the skin barrier, it helps alleviate irritation, retain moisture, and smooth the skin's surface. Noteworthy for its efficacy against specific bacteria like Propionibacterium acnes and Staphylococcus aureus, phytosphingosine has been documented to improve the condition of acne-prone skin, complementing existing acne treatments. Furthermore, it mitigates inflammation of acne lesions, often triggered by hormonal imbalance and clogged pores, and reduces UV-induced irritation, serving as a valuable anti-inflammatory agent. This versatile compound is also integral to anti-aging and skin-soothing formulations, effectively diminishing the appearance of irritated and inflamed skin, and promoting a healthier, more radiant complexion.
What evidence is there to support the effectiveness of phytosphingosine in treating acne?
Phytosphingosine's effectiveness in treating acne has been substantiated through both in vitro and in vivo clinical studies. These studies demonstrated that phytosphingosine, even at a minimal concentration of 0.2% in formulations, significantly improves skin condition. Clinical photographs taken before and after a 60-day treatment period showed noticeable improvements when comparing a phytosphingosine treatment group to a placebo group.
What benefits does phytosphingosine offer for skin health?
Phytosphingosine is obtained through yeast fermentation, making it a natural ingredient with ECOCERT certification. It serves as a potent antimicrobial and anti-inflammatory agent, promoting cell renewal and enhancing skin hydration. By maintaining and restoring the integrity of the skin barrier, it offers synergistic effects in the treatment of acne. Additionally, it increases skin hydration, reduces roughness, and improves the appearance of redness, inflammation, and skin blemishes.
How does phytosphingosine contribute to improved skin hydration?
Phytosphingosine improves skin hydration by increasing the skin's water retention capacity, which in turn reduces roughness. This enhanced hydration helps maintain skin smoothness and elasticity, contributing to a healthier and more resilient skin barrier.
Can phytosphingosine help reduce skin inflammation and blemishes?
Yes, phytosphingosine can help reduce skin inflammation and blemishes due to its anti-inflammatory properties. By promoting cell renewal and maintaining the skin's integrity, it aids in improving the appearance of redness and blemishes associated with acne and other skin conditions.
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