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| Catalog Number | CI-BP-0050 |
| Product Name | Pentapeptide-34 trifluoroacetate |
| Purity | 0.95 |
| Appearance | White powder |
| Application | Whitening and brightening skin |
| Storage | -15~-20 °C |
| Safety | No heavy metals, no skin and eye irritation |
Pentapeptide-34 Trifluoroacetate, commercially known as Peptide Q10™, is a synthetic peptide that plays a crucial role in enhancing intracellular processes. It promotes the activity and synthesis of the Trans-prenyltransferase enzyme, which is essential for boosting coenzyme Q10 production. This increase in coenzyme Q10 aids in the generation of ATP, the primary energy molecule within cells, thereby improving cell vitality and protection against oxidative damage caused by free radicals. Pentapeptide-34 Trifluoroacetate has shown to invigorate dermal cells, enhancing their renewal rate, activity, and overall vitality while bolstering natural defenses against oxidative stress and premature aging. Ex vivo studies have demonstrated its effectiveness in shielding dermal cell cultures from oxidative damage induced by UVB exposure and peroxides while combating glycation. By elevating intracellular ATP levels, this peptide significantly supports cutaneous cell functions. When integrated into anti-aging formulations, Pentapeptide-34 Trifluoroacetate serves as an effective treatment for addressing age-related declines in coenzyme Q10, offering protection against environmental and physicochemical stressors, and serving as a potent measure against premature aging.
Narda, Mridvika, et al. Clinical, Cosmetic and Investigational Dermatology, 2019, 533-544.
This work developed a water-based anti-aging SPF50 sunscreen formulation containing photolyase encapsulated in liposomes, active biopeptides (palmitoyl tripeptide-38 and pentapeptide-34 trifluoroacetate), antioxidants, and hyaluronic acid. The efficacy of the anti-pollution and anti-aging sunscreen product was evaluated in in vitro, ex vivo, and clinical studies.
· Product Formulation
This water-based SPF 50 facial sunscreen features both organic and inorganic UV filters, including butyl methoxydibenzoylmethane, ethylhexyl methoxycinnamate, ethylhexyl triazone, and titanium dioxide. It is enriched with a powerful blend of antioxidants such as tocopheryl acetate, tocopherol, butylated hydroxytoluene, ascorbyl palmitate, and ascorbic acid. Additionally, it contains photolyase from plankton extract, which aids in DNA repair, along with ingredients that offer pollutant protection and anti-aging benefits, including sodium hyaluronate, palmitoyl tripeptide-38, and pentapeptide-34 trifluoroacetate.
· Efficacy Evaluation Results
The formula showed strong efficacy in protecting against UV- and pollution-induced skin damage. It completely prevented CPD formation and had a high degree of protection against SBC formation, approaching the levels of non-irradiated skin, while reducing the expression of genes associated with inflammation and oxidative stress. In terms of pollution protection, the formula significantly reduced MDA levels (a marker of oxidative stress) by 23% and attenuated the upregulation of the Nrf2 signaling pathway and CYP1A1. In clinical performance, it reduced the number and area of brown spots and UV spots.
Liu, Wei, et al. Journal of Cosmetic Dermatology, 2023, 22(1), 245-254.
This work evaluated the efficacy of a skin care system (LVS System) consisting of separate day and night serums for skin exposed to air pollution. The current analysis showed that LVS plus a basic moisturizer reduced skin pigmentation and redness and reduced sebum production more than a basic moisturizer alone in subjects exposed to air pollution.
Formula Composition and Function
· Key ingredients in the day serum include agents that protect against oxidative stress, solar radiation, air pollution, and inflammation, such as Theobroma cacao (cocoa) seed extract, Peruvian pink pepper tree (Schinus molle) extract, Dunaliella salina extract, Polygonum aviculare (saxifrage) extract, and Physalis alba (wild gooseberry) extract.
· Key ingredients in the night serum provide indirect antioxidant protection as well as skin repair needs and include Mitoquine mesylate, Pentapeptide-34 Trifluoroacetate, Mirabilis jalapa (Mirabilis jalapa) callus extract, Vitis vinifera (grape) flower cell extract, and Vibrio alginolyticus ferment filtrate.
· Both the day and night serums contain Acetyl Tetrapeptide-2 to support the extracellular matrix and elasticity, and Alteromonas Ferment Extract to provide protection against specific pollutants.
What is Pentapeptide-34 Trifluoroacetate, and how does it work?
Pentapeptide-34 Trifluoroacetate is a synthetic peptide with the sequence Ala-Val-Leu-Ala-Gly-TFA. It is designed to enhance the production and activity of the Trans-prenyltransferase enzyme, which is crucial for the synthesis of Coenzyme Q10 in dermal cells. By stimulating this enzyme, Pentapeptide-34 Trifluoroacetate boosts intracellular ATP production, thereby improving cell vitality and protecting against oxidative damage.
What are the benefits of using Pentapeptide-34 Trifluoroacetate in skincare formulations?
The inclusion of Pentapeptide-34 Trifluoroacetate in skincare products offers multiple benefits, such as enhancing cellular renewal rates and activity, energizing dermal cells, and improving their ability to combat oxidative stress and free radicals. Moreover, it helps protect the skin from UVB- and peroxide-induced oxidative damage, fights glycation, and provides a compensatory treatment for the decline of Coenzyme Q10 often associated with aging.
How does Pentapeptide-34 Trifluoroacetate improve the skin's defense mechanisms?
Pentapeptide-34 Trifluoroacetate enhances the skin's natural protective mechanisms by stimulating the production of Coenzyme Q10, which is known for its role in ATP production and protection against oxidative damage. By boosting cellular energy levels and strengthening the skin's resilience against environmental stressors, it helps safeguard the skin against premature aging and other physicochemical damage.
Can Pentapeptide-34 Trifluoroacetate reverse signs of aging?
While Pentapeptide-34 Trifluoroacetate itself may not reverse all signs of aging, it significantly aids in the process by enhancing cellular functions, protecting against oxidative stress, and boosting energy levels in skin cells. By doing so, it helps to slow down the visible effects of aging, thus being an effective component in anti-aging skincare regimens.
Are there any studies supporting the effectiveness of Pentapeptide-34 Trifluoroacetate?
Yes, ex vivo studies on dermal cell cultures treated with Pentapeptide-34 Trifluoroacetate have demonstrated its ability to protect cells from oxidative damage caused by UVB and peroxide, fight glycation, and activate the synthesis of intracellular ATP. These studies underscore its role in improving cellular energy and resilience, which contributes to its effectiveness in anti-aging skincare formulations.
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