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| Catalog Number | CI-BP-0020 |
| Product Name | Pentapeptide-3 |
| CAS | 135679-88-8 |
| Structure |  |
| Synonyms | L-Alaninamide, glycyl-L-prolyl-L-arginyl-L-prolyl-; Vialox; GF-2TKS; Pentapeptide 3 |
| Molecular Weight | 495.576 g/mol |
| Molecular Formula | C21H37N9O5 |
| Boiling Point | It is commonly used in formulations where color change is observed to help maintain the natural blue/purple color over time. |
| Purity | 95% by HPLC |
| Appearance | Lyophilized powder |
| Application | Wrinkle smoothing and skin relaxing |
| Storage | Keep in dark and cool dry place -5~8°C |
Pentapeptide-3, a synthetic peptide with the sequence Gly-Pro-Arg-Pro-Ala-NH2, marketed under the trade name Vialox peptide, is designed for topical cosmetic applications. Operating as an acetylcholine (ACh) competitive antagonist, it mimics the action of curare by blocking receptors on cellular membranes, thereby inhibiting signal transmission from neurons to muscles. This action results in a neuromuscular blocking effect, similar to Botox®, yet without requiring injections. By preventing the release of sodium ions and ultimately muscle contractions at the post-synaptic membrane, Pentapeptide-3 effectively reduces expression lines and deep wrinkles, such as crow's feet and nasolabial folds. Its use provides a safe, non-invasive alternative for those seeking to diminish facial muscle contractions and achieve smoother skin.
What is Pentapeptide-3, and how does it work?
Pentapeptide-3, also known by the trade name Vialox peptide, is a synthetic peptide with the sequence Gly-Pro-Arg-Pro-Ala-NH2. It functions as an acetylcholine (ACh) competitive antagonist, which means it blocks the membrane's receptors, creating an effect similar to that of curare-a natural paralytic agent. By mimicking curare's action, Pentapeptide-3 acts as a neuromuscular blocking agent, obstructing signal transfer from neurons to muscles, thereby relaxing muscle contractions.
How does Pentapeptide-3 compare to Botox?
Pentapeptide-3 offers a needle-free alternative to Botox injections by blocking acetylcholine receptors and preventing muscle contraction. While Botox is injected, Pentapeptide-3 is applied topically. It effectively smooths expression lines and deep wrinkles such as crow's feet, forehead lines, and nasolabial folds by relaxing facial muscles and reducing their contractions.
Is Pentapeptide-3 safe for use?
Extensive testing suggests that Pentapeptide-3 is safe for topical cosmetic applications. It is considered an effective and non-invasive alternative to Botox injections, providing similar benefits without the use of needles.
What are the benefits of using Pentapeptide-3?
The primary benefits of using Pentapeptide-3 include the smoothing of expression lines and reduction of deep wrinkles by relaxing facial muscles. It is particularly effective for areas like crow's feet, forehead lines, and nasolabial folds. As a topical application, it provides a non-invasive method to achieve results similar to those of Botox injections.
How does Pentapeptide-3 affect muscle contraction?
By acting as a competitive antagonist to acetylcholine, Pentapeptide-3 blocks acetylcholine receptors at the post-synaptic membrane, preventing sodium channels from opening. This inhibition of Na+ release ultimately prevents muscle contraction, leading to a reduction in the appearance of expression lines and wrinkles.
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