Our customer service representatives are available 24 hours a day, from Monday to Sunday.
| Catalog Number | CI-BP-0105 |
| Product Name | Pentapeptide-59 |
| Purity | 0.95 |
| Safety | No heavy metals, no skin and eye irritation |
Pentapeptide-59 is a synthetic peptide specifically designed to address skin sensitivity by leveraging natural mechanisms to deactivate dermal pain receptors. This innovative solution is derived from a targeted sequence (Arg-Arg-Arg-Phe-Val) of a sea anemone venom protein, APHC1, known for its ability to inhibit overreactions of the TRPV1 pain receptor. Although the full APHC1 protein is both unstable and too large to effectively penetrate the skin barrier, Pentapeptide-59, developed by Mibelle Biochemistry in collaboration with the UK Venomtech Institute, replicates the active binding site for more efficient receptor inhibition. Its synthetic production not only enhances sustainability by bypassing the need for sea anemone extraction but also demonstrates superior efficacy in vitro. Research indicates that Pentapeptide-59 successfully inhibits the TRPV1 receptor activation more effectively than the full-length protein, reducing receptor activity by up to 80% when compared to the 25% inhibition observed with the complete APHC1 protein.
What is Pentapeptide-59?
Pentapeptide-59 is a synthetic peptide designed to address skin sensitivity by utilizing the natural mechanisms of dermal pain receptor inactivation. It is derived from a sequence of the APHC1 protein, found in sea anemone (Heteractis Crispa) venom, specifically targeting the TRPV1 pain receptor.
How does Pentapeptide-59 help in reducing skin sensitivity?
Pentapeptide-59 works by inhibiting the overreactivity of the TRPV1 pain receptor found in the skin, which is responsible for heightened sensitivity and discomfort. Its efficacy in minimizing receptor activation has been demonstrated in controlled cellular studies, showing an 80% reduction in receptor activation compared to the full-length APHC1 protein.
Why is Pentapeptide-59 more effective than the entire APHC1 protein?
The complete APHC1 protein is unstable for formulation and too large to effectively penetrate the skin. Pentapeptide-59, however, is a streamlined version that maintains the active sequence needed for receptor inhibition, making it more efficient and practical for skincare applications.
What makes Pentapeptide-59 a sustainable skincare ingredient?
Pentapeptide-59 is synthetically produced, eliminating the need to harvest venom from sea anemones, thereby providing a sustainable option for skincare products without impacting marine biodiversity.
How was the efficacy of Pentapeptide-59 tested?
The efficacy of Pentapeptide-59 was tested in vitro using CHO cells that express TRPV1 receptors. These cells were exposed to capsaicin, a known TRPV1 activator, in the presence and absence of Pentapeptide-59. The results demonstrated a significant 80% reduction in receptor activation, confirming its potent efficacy.
If you have any questions, please contact us. You will get a satisfactory answer.
