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| Catalog Number | CI-SC-1276 |
| Product Name | Panthenol |
| CAS | 81-13-0 |
| Structure |  |
| Synonyms | Panthenol;D-Pantothenol;Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-;Provitamin B5 |
| IUPAC Name | (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide |
| Molecular Weight | 205.25 g/mol |
| Molecular Formula | C9H19NO4 |
| InChI | InChI=1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m0/s1 |
| InChI Key | SNPLKNRPJHDVJA-ZETCQYMHSA-N |
| Boiling Point | 118-120 °C / 2.7mmHg |
| Melting Point | 64-69 °C |
| Purity | 95% |
| Density | 1.2 g/mL |
| Appearance | Liquid |
| Highest Usage In Residency Products | 0.4 |
| Isomeric SMILES | CC(C)(CO)[C@H](C(=O)NCCCO)O |
Panthenol, a provitamin form of Vitamin B5, plays an instrumental role in skincare haircare and nail care due to its multi-functional properties. As a key component of coenzyme A, panthenol facilitates essential biochemical processes including synthesis of lipids and proteins. In skincare, it acts as a deep-penetrating moisturizer promoting cell proliferation and aiding in tissue repair and normal keratinization, which may enhance wound healing and alleviate various dermatological conditions. For hair, panthenol penetrates rapidly and binds strongly with amino acids, providing long-lasting moisturization that protects against brittleness and breakage strengthens hair and reduces damage from heat and dryness. Additionally, it nourishes and conditions hair without leaving any buildup, and helps prevent split-ends. In nail care, panthenol is absorbed into the nail matrix reducing brittleness and enhancing nail strength.
Camargo Jr F B, et al. Journal of cosmetic science, 2011, 62(4), 361.
Panthenol, the biologically active alcohol analogue of pantothenic acid is a pro-vitamin of the B-complex group that is a normal constituent of skin and hair. This study measured skin moisturizing capacity of formulas that contained various levels of panthenol. The results showed that the panthenol-based formulations increased skin moisture and had a significant effect on the skin barrier function by reducing the TEWL value. By including 1.0% panthenol, the formulation increased its protective activity and preserved the integrity of skin.
Evaluation Methods and Results
· These formulations, with or without 0.5%, 1.0%, or 5.0% panthenol added, were used every day on the forearms of healthy participants. The skin moisture and transepidermal water loss (TEWL) profiles were analyzed before and after the application period of 15 and 30 days. After 30 days of application, the panthenol-containing formulations (1.0% and 5.0%) resulted in a significant reduction in TEWL.
· The formulations were also applied after washing the skin with sodium laureth sulfate (SLES) to evaluate the direct effect on TEWL and skin moisture. In skin cleansed with SLES, TEWL was significantly reduced two hours after application of the formulation containing panthenol compared with the control and vehicle.
Pavlačková, Jana, et al. Journal of Cosmetic Dermatology, 2019, 18(1), 346-354.
To evaluate the efficacy of panthenol in cosmetic and pharmaceutical semi-solid formulations, this work added 5-13 wt% panthenol to o/w and w/o emulsions to investigate whether these formulations can increase moisturizing effects and enhance the skin's Barrier performance. Results showed that o/w and w/o semi-solid formulations containing panthenol significantly enhanced skin barrier repair and stratum corneum moisturization. In terms of moisturizing effects, o/w formulas are better carriers of actives.
· Semi-solid formulations containing panthenol
The composition of formulations is stated in agreement with the INCI in order from the substances in the highest representation to the substances in the lowest representation.
Hydrophilic (o/w) formulations: aqua, panthenol, caprylic/capric triglyceride, glyceryl stearate, ceteareth-20, ceteareth-12, cetearyl alcohol, cetyl palmitate, sodium polyacrylate, hydrogenated polydecene, trideceth-6, phenoxyethanol, ethylhexylglycerin.
Lipophilic (w/o) formulations: lanolin, aqua, petrolatum, panthenol, zinc oxide, glyceryl stearate, cetearyl alcohol, helianthus annuus seed oil, alkyl benzoate, isostearic acid, phenoxyethanol, ethylhexylglycerin.
· Assessment results
Tested on 40 women, skin hydration increased and transepidermal water loss decreased after application of a formula containing 7-11 wt% panthenol in either form. After application of the test formula, the skin's pH level shifted toward neutral. The rheological properties of the formulation are affected by vehicle type, panthenol content and temperature. Sensory evaluation of both semi-solid forms showed statistically significant differences in spreadability between the o/w formulations.
What is Panthenol, and how does it relate to Vitamin B5?
Panthenol is a provitamin of pantothenic acid (vitamin B5), belonging to the B-complex group of water-soluble vitamins. It is an alcohol form of the D-isomer of pantothenic acid and plays a crucial role as a constituent of coenzyme A. Coenzyme A is fundamental for acetylation reactions, which are essential for synthesizing lipids, proteins, and the connection between lipids, proteins, and carbohydrates.
How does Panthenol benefit the skin?
Panthenol acts as a quick, deep-penetrating moisturizer, which can stimulate fibroblast proliferation and assist in tissue repair. It is also claimed to promote normal keratinization and wound healing in various skin conditions such as surgical, traumatic, and thermally induced wounds. Additionally, Panthenol is considered effective in treating dermatological disorders like atopic dermatitis, diaper rash, and itching.
What are the benefits of Panthenol in hair care?
In hair care, Panthenol (pro-vitamin B5) converts to pantothenic acid, a natural component of healthy hair. It enhances hair strength and increases resistance to breakage while preventing damage from excessive heat and dryness. Panthenol nourishes by replenishing and increasing vitamin B5 levels in the hair, providing long-lasting moisturization, conditioning without build-up, and reducing split-end formation.
Can Panthenol be used for nail care?
Yes, Panthenol is beneficial in nail care as it is absorbed into the nails, helping to reduce brittleness. By penetrating the nail structure, it improves nail flexibility and strength.
Are there any known side effects or concerns with using Panthenol?
Panthenol is generally considered safe and well-tolerated for topical use in various products, including skin, hair, and nail care. However, users should follow the specific product's instructions and consult a healthcare professional if they experience any adverse reactions or have concerns about the product's suitability for their skin type or condition.
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