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Palmitoyl Pentapeptide

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Catalog Number	CI-BP-0003
Product Name	Palmitoyl Pentapeptide
CAS	214047-00-4
Structure
Synonyms	Matrixyl
IUPAC Name	(2S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid
Molecular Weight	802.05 g/mol
Molecular Formula	C39H75N7O10
InChI	InChI=1S/C39H75N7O10/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-23-32(50)42-29(21-17-19-24-40)36(52)45-34(28(3)49)38(54)46-33(27(2)48)37(53)43-30(22-18-20-25-41)35(51)44-31(26-47)39(55)56/h27-31,33-34,47-49H,4-26,40-41H2,1-3H3,(H,42,50)(H,43,53)(H,44,51)(H,45,52)(H,46,54)(H,55,56)/t27-,28-,29+,30+,31+,33+,34+/m1/s1
InChI Key	WSGCRSMLXFHGRM-DEVHWETNSA-N
Boiling Point	1120.1±65.0 °C
Purity	0.95
Density	1.15 g/mL
Appearance	Solid
Isomeric SMILES	CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O
pKa	2.98±0.10

Product Overview

Palmitoyl Pentapeptide, commonly known as Matrixyl™, is a specially modified peptide developed to enhance skin treatment applications by leveraging its improved stability and activity for topical use. This derivative of the naturally occurring Pentapeptide-4 addresses the challenge of peptide delivery across the skin by adding a palmitoyl group, which enhances its compatibility with the lipophilic environment of the skin. As a result, Matrixyl™ effectively stimulates the production of collagen and other components of the dermal matrix, promoting epidermal thickening and reducing the appearance of wrinkles associated with aging. Numerous studies have demonstrated that the use of Palmitoyl Pentapeptide not only improves facial wrinkle appearance through both expert analysis and self-assessment but also mitigates skin irritation commonly linked to other anti-aging agents like retinol. Furthermore, it supports skin firmness and addresses signs of aging such as age spots and dark circles, making it a comprehensive ingredient in advancing the benefits of cosmetic skincare.

Custom Q&A

What are the main anti-aging benefits of Palmitoyl Pentapeptide?

Palmitoyl Pentapeptide, commonly known as Matrixyl™, is known for its dual action in combating the signs of aging. It promotes increased collagen production, which helps reduce wrinkles and improve skin elasticity. Additionally, it reduces the excessive accumulation of glycosaminoglycans (GAGs), addressing issues related to texture and moisture retention in aging skin. These mechanisms make it effective in reducing the appearance of wrinkles, dryness, uneven pigmentation, red blotchiness, and loss of elasticity.

How does Palmitoyl Pentapeptide work in the skin?

The active ingredient in Palmitoyl Pentapeptide, known as Pal-KTTKS, works by stimulating collagen synthesis in the skin. By promoting new collagen production, it helps to restore skin firmness and elasticity. Simultaneously, it aims to decrease the excess presence of GAGs, which can lead to improved skin texture and moisture balance. Thus, Palmitoyl Pentapeptide effectively targets and reduces several visible signs of skin aging.

Is Palmitoyl Pentapeptide safe to use in combination with other anti-aging ingredients?

Yes, Palmitoyl Pentapeptide is compatible with other active anti-aging ingredients, such as Niacinamide. Niacinamide, a form of Vitamin B3, is known for its anti-aging benefits, including improved skin texture, reduced wrinkles, and enhanced skin barrier function. Studies have shown that combining Pal-KTTKS with Niacinamide can lead to more pronounced improvements in skin texture and reduced wrinkles, making it an effective strategy for achieving comprehensive anti-aging benefits.

Can I expect quick results from using Palmitoyl Pentapeptide?

While Palmitoyl Pentapeptide is known for its effectiveness in addressing the signs of aging, results can vary depending on individual skin type and condition. Generally, consistent use over a period of weeks may be necessary to see significant improvements. It is recommended to combine Palmitoyl Pentapeptide with other supportive skincare practices for optimal results.

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