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| Catalog Number | CI-BP-0047 |
| Product Name | Oligopeptide-68 |
| CAS | 1206525-47-4 |
| Structure |  |
| Synonyms | Aspartyl-L-threonyl-L-glutamine |
| Molecular Weight | 1410.49 g/mol |
| Molecular Formula | C62H91N17O21 |
| InChI Key | HPPYJXKCLMBZCN-UQEYPLSQNA-N |
| Density | 1.52 g/mL |
| pKa | 3.19±0.10 |
Oligopeptide-68 is utilized primarily for its ability to address various skin pigmentation issues such as melasma, hyperpigmentation, and dark spots. This peptide consists of ten amino acids in the sequence Arg-Asp-Gly-Gln-Ile-Leu-Ser-Thr-Trp-Tyr and functions as a key component in β-WHITE™. As a signal peptide, it effectively interacts with the microphthalmia-associated transcription factor (MITF), resulting in the inhibition of melanocyte differentiation and development. By reducing the activity of tyrosinase, Oligopeptide-68 significantly decreases melanin production, offering a notable solution to pigmentation problems. Research indicates that it surpasses traditional options like hydroquinone in efficacy, while also presenting fewer and less severe side effects.
Pratchyapurit, Walai-orn. Journal of Cosmetic Dermatology, 2016, 15(2), 131-144.
This study assessed the effectiveness and safety of two formulations featuring diacetylcholine (DAB) and TGF-β1 biomimetic oligopeptide-68 for treating facial melasma, comparing their performance against 2% and 4% hydroquinone cream (HQ) on sun-protected, normal skin.
· Evaluation methods and results
A randomized, double-blind study lasting 12 weeks involved 40 female participants, with 38 completing the trial. Melasma showed significant improvement by weeks 6 and 12 compared to baseline (P < 0.05), with no severe adverse reactions reported. Most participants experienced temporary mild skin reactions. Approximately 2.6% reported significant improvement, 76.3% noted moderate improvement, and 21.1% observed slight improvement. Both formulations demonstrated greater efficacy and faster results in reducing pigmentation than HQ.
· Recommended formula usage
Use DAB serum at night and DAB/TGF-β1 biomimetic oligopeptide-68/sunscreen in the morning and at noon. It is effective and safe for facial melasma and is superior to HQ in reducing pigmentation.
Agozzino, Marina, et al. The Journal of Clinical and Aesthetic Dermatology, 2020, 13(9), 41.
This study tested the safety and efficacy of a topical depigmenting complex consisting of oligopeptide-68, phytic acid, glycolic acid, lactic acid and octinoxate, which is capable of reducing melanogenesis, improving antioxidant protection and skin renewal.
Evaluation Methods and Results
Twenty female patients between the ages of 29 and 61 with clinically significant melasma were randomly assigned. Reflectance confocal microscopy was used at baseline and after three months of therapy. No patients suffered any adverse effects after treatment of melasma. Analysis of the treatment response by confocal microscopy revealed sharp brightness loss, mainly at the epidermis and dermal-epidermal junction (DEJ).
In this study, it showed that a topical combination of oligopeptide-68, phytic acid, glycolic acid, lactic acid and octinoxate effectively and rapidly improved melasma clinically and cellularly.
What is Oligopeptide-68, and how does it work?
Oligopeptide-68 is a decapeptide consisting of ten amino acids with the sequence Arg-Asp-Gly-Gln-Ile-Leu-Ser-Thr-Trp-Tyr. This signal peptide interacts with microphthalmia-associated transcription factor (MITF), thereby inhibiting the differentiation and development of melanocytes. By reducing tyrosinase activity, Oligopeptide-68 decreases melanin production, effectively combating melasma, hyperpigmentation, and dark spots.
How is Oligopeptide-68 different from other skin-lightening agents like hydroquinone?
Studies indicate that Oligopeptide-68 is more effective than hydroquinone in reducing hyperpigmentation without the advanced side effects often associated with hydroquinone. Its targeted action on the MITF factor and tyrosinase activity makes it a potent and safer alternative for skin lightening.
Can Oligopeptide-68 be used by individuals with sensitive skin?
Oligopeptide-68 is formulated to be gentle on the skin while effectively reducing hyperpigmentation and dark spots. However, it is always recommended for individuals with sensitive skin to perform a patch test or consult with a dermatologist prior to using new skincare products to ensure compatibility and prevent any adverse reactions.
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