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| Catalog Number | CI-BP-0047 |
| Product Name | Oligopeptide-68 |
| CAS | 1206525-47-4 |
| Structure |  |
| Synonyms | Aspartyl-L-threonyl-L-glutamine |
| Molecular Weight | 1410.49 g/mol |
| Molecular Formula | C62H91N17O21 |
| InChI Key | HPPYJXKCLMBZCN-UQEYPLSQNA-N |
| Density | 1.52 g/mL |
| pKa | 3.19±0.10 |
Oligopeptide-68 is utilized primarily for its ability to address various skin pigmentation issues such as melasma, hyperpigmentation, and dark spots. This peptide consists of ten amino acids in the sequence Arg-Asp-Gly-Gln-Ile-Leu-Ser-Thr-Trp-Tyr and functions as a key component in β-WHITE™. As a signal peptide, it effectively interacts with the microphthalmia-associated transcription factor (MITF), resulting in the inhibition of melanocyte differentiation and development. By reducing the activity of tyrosinase, Oligopeptide-68 significantly decreases melanin production, offering a notable solution to pigmentation problems. Research indicates that it surpasses traditional options like hydroquinone in efficacy, while also presenting fewer and less severe side effects.
What is Oligopeptide-68, and how does it work?
Oligopeptide-68 is a decapeptide consisting of ten amino acids with the sequence Arg-Asp-Gly-Gln-Ile-Leu-Ser-Thr-Trp-Tyr. This signal peptide interacts with microphthalmia-associated transcription factor (MITF), thereby inhibiting the differentiation and development of melanocytes. By reducing tyrosinase activity, Oligopeptide-68 decreases melanin production, effectively combating melasma, hyperpigmentation, and dark spots.
How is Oligopeptide-68 different from other skin-lightening agents like hydroquinone?
Studies indicate that Oligopeptide-68 is more effective than hydroquinone in reducing hyperpigmentation without the advanced side effects often associated with hydroquinone. Its targeted action on the MITF factor and tyrosinase activity makes it a potent and safer alternative for skin lightening.
Can Oligopeptide-68 be used by individuals with sensitive skin?
Oligopeptide-68 is formulated to be gentle on the skin while effectively reducing hyperpigmentation and dark spots. However, it is always recommended for individuals with sensitive skin to perform a patch test or consult with a dermatologist prior to using new skincare products to ensure compatibility and prevent any adverse reactions.
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