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| Catalog Number | CI-GU-0206 |
| Product Name | Methylisothiazolinone |
| CAS | 2682-20-4 |
| Structure |  |
| Synonyms | Methylisothiazolinone;3(2H)-Isothiazolone, 2-methyl- |
| IUPAC Name | 2-methyl-1,2-thiazol-3-one |
| Molecular Weight | 115.15 g/mol |
| Molecular Formula | C4H5NOS |
| InChI | InChI=1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3 |
| InChI Key | BEGLCMHJXHIJLR-UHFFFAOYSA-N |
| Melting Point | 254-256 °C |
| Purity | 95% |
| Density | 1.25 g/mL |
| Appearance | Solid |
| Isomeric SMILES | CN1C(=O)C=CS1 |
Methylisothiazolinone, a compound from the Isothiazolinone family, is extensively used as a preservative in a variety of personal care products due to its broad-spectrum antimicrobial efficacy. It effectively inhibits the growth of bacteria, mold, yeast, and microalgae even in minimal concentrations up to 0.01%, making it suitable for both leave-on and rinse-off formulations. Commonly incorporated within hair care, body care, sun protection products, perfumes, and liquid soaps, Methylisothiazolinone operates efficiently across a wide pH spectrum and is compatible with various surfactants, proteins, and other antiseptic agents. It is often combined with other preservatives, such as Methylchloroisothiazolinone, to enhance antimicrobial activity and reduce necessary concentrations. Known for its ease of use, formaldehyde-free nature, and stability up to 70°C, Methylisothiazolinone provides significant antimicrobial protection and versatility. However, it should be noted that this compound is recognized as an allergen, with instances of contact dermatitis and sensitization reported, and it poses ecological concerns due to its impact on aquatic organisms.
What is Methylisothiazolinone, and what are its primary uses?
Methylisothiazolinone is a heterocyclic compound classified under the Isothiazolinone family. It is primarily used as a broad-spectrum preservative in personal care products. This compound is effective in small concentrations, up to 0.01%, for preventing the growth of bacteria, mold, yeast, and microalgae. Common applications include hair care, body care, sun care products, perfumes, and liquid soaps.
How effective is Methylisothiazolinone as a preservative?
Methylisothiazolinone is highly effective as a preservative due to its broad-spectrum antimicrobial properties. It exhibits good effectiveness against both Gram-negative and Gram-positive bacteria and remains active across a wide range of pH values. Additionally, it is compatible with various surfactants, proteins, and other antiseptics, including fungicides.
Can Methylisothiazolinone be used in combination with other preservatives?
Yes, Methylisothiazolinone is often used in combination with other preservatives from the Isothiazolinone family, such as Methylchloroisothiazolinone. When used together, these compounds enhance preservation effectiveness through a potentiating action, which broadens the antimicrobial activity range and allows for reduced concentrations.
Are there any safety concerns associated with the use of Methylisothiazolinone?
Methylisothiazolinone is a known allergen and has been linked to several cases of contact dermatitis and sensitization. Users should be cautious and consider potential allergic reactions. Its use is subject to regulation, and it is important for manufacturers to adhere to appropriate safety guidelines.
What are the environmental impacts of Methylisothiazolinone?
Methylisothiazolinone is considered harmful to aqueous microorganisms and possesses a poor ecological profile. Its environmental impact should be carefully considered, especially in terms of water safety and ecological sustainability.
At what temperatures does Methylisothiazolinone remain stable and effective?
Methylisothiazolinone retains its stability and efficacy at temperatures up to 70°C. This stability provides versatility and effective antimicrobial protection in various personal care formulations.
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