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Kaempferol

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Catalog Number CI-GU-0071
Product Name Kaempferol
CAS 520-18-3
Structure
Synonyms 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on
IUPAC Name 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
Molecular Weight 286.23 g/mol
Molecular Formula C15H10O6
InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
InChI Key IYRMWMYZSQPJKC-UHFFFAOYSA-N
Boiling Point 348.5 °C
Melting Point 276 °C
Purity 95%
Density 1.29 g/mL
Appearance Solid
Highest Usage In Residency Products 0.0005
Isomeric SMILES C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
pKa 6.34±0.40
Custom Q&A

What is Kaempferol used for in cosmetics?

Kaempferol is a natural flavonoid widely used in cosmetics due to its antioxidant and anti-inflammatory properties. It is primarily used to address issues related to skin aging, oxidative damage, and inflammation. It can be found in products aimed at reducing wrinkles, whiten skin, and decrease skin inflammation.

How does Kaempferol contribute to anti-wrinkle products?

Kaempferol, particularly in the form of kaempferol tetrasaccharides, helps reduce cellular senescence and increase collagen fiber in the skin. This contributes to the anti-wrinkle effects, helping to maintain skin elasticity and reduce the appearance of fine lines.

Can Kaempferol help with skin whitening, and if so, how?

Yes, Kaempferol, specifically kaempferol-7-O-α-l-rhamnopyranoside, can enhance the whitening effectiveness of cosmetic formulations. This makes it a valuable component in products designed to promote a more even skin tone and reduce pigmentation.

How does Kaempferol reduce skin inflammation?

Kaempferol helps block the expression of interleukin 1β, a cytokine involved in the inflammatory response. By doing so, it effectively reduces skin inflammation, making it beneficial for soothing sensitive or irritated skin.

What is the role of Kaempferol in inhibiting the PDK1 enzyme?

Kaempferol tetrasaccharides can inhibit the activity of the PDK1 enzyme. This inhibition is associated with a reduction in cellular senescence and an increase in collagen fibers, contributing to healthier and more resilient skin.

How does Kaempferol affect the ROS/JNK/NF-κB signaling pathway?

Kaempferol can ameliorate the ROS/JNK/NF-κB signaling pathway, which is involved in skin inflammation and oxidative damage. By modulating this pathway, Kaempferol helps protect the skin from oxidative stress and maintain its overall health.

Where can Kaempferol be sourced from?

Kaempferol is found in a variety of fruits, vegetables, and plant-derived beverages. It can also be isolated from sources like Delphinium, Witch-hazel, and grapefruit, making it a readily available ingredient for cosmetics and other products.

Are there other uses for Kaempferol outside of cosmetics?

Beyond cosmetics, Kaempferol is used in dietary supplements and as a natural therapeutic agent for managing various ailments due to its beneficial properties. Its versatility extends to health and wellness applications, leveraging its natural origins and multiple health benefits.

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