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| Catalog Number | CI-SC-1015 |
| Product Name | Hyaluronic Acid (CAS 9004-61-9) |
| CAS | 9004-61-9 |
| Structure |  |
| Description | Hyaluronic Acid is a naturally occurring substance that's found in our bodies, particularly in our connective tissues, skin, and eyes. It is a glycosaminoglycan or a type of polysaccharide that plays a crucial role in keeping the skin plump, hydrated, and youthful-looking. It acts as a humectant, meaning it attracts and retains moisture, making it an essential ingredient in many skincare and cosmetic products. When used topically, hyaluronic acid helps to keep the skin hydrated, reducing the appearance of fine lines, wrinkles, and dryness. Additionally, it has anti-inflammatory properties, helping to calm and soothe the skin. When injected, it is often used to fill in wrinkles and fine lines, plump up the lips, and add volume to the cheeks. |
| Appearance | clear, viscous, and gel-like substance |
| Application | 1. Skin hydration: Hyaluronic Acid is commonly used in skincare products due to its ability to hydrate skin cells and improve skin texture and tone. 2. Wound healing: being a natural component of the extracellular matrix, hyaluronic acid plays a crucial role in tissue repair and regeneration. 3. Joint lubrication: hyaluronic acid acts as a lubricant and shock absorber in joints, therefore it is often used in joint supplements and injections to alleviate joint pain and stiffness. 4. Eye health: hyaluronic acid is a key component of the vitreous humor, the clear, jelly-like substance that fills the inner part of the eye. It helps to maintain the shape of the eye and protect it from damage. 5. Dental care: hyaluronic acid is used in dental products such as mouthwash, toothpaste, and gels to prevent gum disease and promote tissue healing after dental surgery. |
| Features And Benefits | 1. Provides intense hydration to the skin. 2. Helps in reducing the appearance of fine lines and wrinkles. 3. Restores the skin's moisture barrier. 4. Gives a plump and youthful appearance to the skin. 5. Helps in reducing dark circles and puffiness. 6. Improves skin elasticity and firmness. 7. Enhances the absorption of other skincare ingredients. 8. Suitable for all skin types. |
Hyaluronic Acid (CAS 9004-61-9) is widely recognized for its significant role in anti-aging skincare solutions. This versatile compound is a key ingredient in various moisturizers, creams, serums, and injectable fillers due to its exceptional ability to retain moisture. As a crucial component of the extracellular matrix in human skin, Hyaluronic Acid works alongside collagen and elastin to maintain the structural integrity of dermal tissue. Its primary function is to ensure optimal hydration by binding to and retaining substantial quantities of water molecules, thereby preventing dehydration and delaying the onset of wrinkles and sagging. Although natural aging processes can reduce its levels in the skin, leading to fine lines and wrinkles, both topical and injectable forms of Hyaluronic Acid have proven effective in mitigating these effects. The compound serves as a powerful humectant, offering comprehensive moisturization based on its molecular size, which allows smaller molecules to penetrate deeper into the skin. Beyond its hydrating properties, Hyaluronic Acid promotes the production of collagen and elastin, enhancing skin volume, plumpness, and firmness. It also exhibits antioxidant and anti-inflammatory capabilities, aiding in the protection against free radicals, photoaging, and inflammation while supporting wound healing and tissue regeneration. Extensive scientific research underscores the compound's efficacy in improving skin hydration, reducing wrinkles, and boosting skin firmness.
Al-Sibani, M., et al. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2017, 72(2), 81-86.
In the biomedical and cosmetic fields, natural hyaluronic acid (HA) has limited applications due to its high water solubility and rapid degradation in the human body, so there is a need to develop cross-linked HA hydrogels. This work investigated the effect of initial HA concentration (7.0 - 14.0 % w/v) on the cross-linking efficiency of HA hydrogels cross-linked with 1,4-butanediol diglycidyl ether (BDDE). The findings indicated that hydrogels consisting of 10.0% HA concentration exhibited reduced degradation rates, decreased swelling capacities, and more uniform porosity. Furthermore, the swelling capacity of the hydrogels steadily decreased with increasing initial HA concentration until 10.0 % HA hydrogels exhibited the lowest swelling ratio.
Synthesis procedure of BDDE-HA hydrogels
· A total of eight cross-linked BDDE-HA hydrogels were prepared by mixing different amounts of HA powder with a basic solution containing BDDE. The initial concentrations of HA in the mixtures were 7.0%, 8.0%, 9.0%, 10.0%, 11.0%, 12.0%, 13.0%, and 14.0%, respectively.
· Each mixture was thoroughly mixed for 2 hours at 40 °C and then neutralized to a pH of approximately 7.0. The resulting hydrogels were dialyzed for 3 days to remove unmodified HA and BDDE residues.
Subsequently, all hydrogels were lyophilized using a Labtech freeze-dryer and stored at 8 °C until further characterization studies were conducted.
Sionkowska, Alina, et al. Pure and Applied Chemistry, 2017, 89(12), 1829-1839.
A film based on a mixture of collagen, chitosan and hyaluronic acid was developed and its properties were characterized to explore its potential for use in hair care cosmetics. The results showed that the introduction of hyaluronic acid improved the mechanical resistance of the biopolymer film, its stability under aqueous conditions and its roughness, and reduced the surface free energy.
Film preparation procedure
· In the laboratory, Collagen (Col) type I was derived from rat tail tendons. The tendons underwent a process of washing in distilled water and dissolution in 0.1 M acetic acid at 4°C for 3 days. Any non-dissolved components were separated through centrifugation at 10,000 rpm for 10 minutes. The frozen mixtures were fully lyophilized at -55°C and 5 Pa for 48 hours. A 1% solution was created by dissolving the collagen in 0.1 M acetic acid.
· Similarly, Chitosan (CS) (low molecular weight) and hyaluronic acid (HA) were dissolved in 0.1 M acetic acid to produce 1% solutions of each.
· Various ratios of chitosan and collagen (25:75, 50:50, 75:25) were blended together, with 1, 2, and 3% of hyaluronic acid added to each solution. Control samples were prepared without the addition of HA. The samples were air-dried at room temperature until the solvent had evaporated.
What is Hyaluronic Acid and why is it important?
Hyaluronic Acid (CAS 9004-61-9) is a naturally occurring substance in the human body and belongs to the class of glycosaminoglycans, which are carbohydrates. It plays a vital role in maintaining the skin's strength, stability, and moisture. Hyaluronic acid is essential for fibroblasts, which are cells responsible for producing important structural components of the skin. Without sufficient moisture, the production of these building blocks is limited, leading to less resilient skin.
How is Hyaluronic Acid used in cosmetics?
Hyaluronic Acid is a popular ingredient in cosmetics due to its impressive ability to retain moisture. This capability allows it to increase its volume like a sponge, thereby helping to fill the skin from within. As a result, it provides the skin with essential moisture, supporting elasticity and imparting a youthful appearance. This makes it a highly effective component in anti-aging skincare products, as it can help reduce the appearance of wrinkles and keep skin looking fresh and plump.
What role does Hyaluronic Acid play in skincare?
In skincare, Hyaluronic Acid acts as a powerful hydrating agent that aids in maintaining skin elasticity and texture. It forms part of the extracellular matrix in the connective tissue, working alongside collagen and elastin fibers. Through its ability to retain moisture, it delivers nutrients to collagen, enhances skin elasticity, and supports cell growth, thereby contributing to overall skin health and vitality.
How was Hyaluronic Acid used before it became popular in cosmetics?
Prior to its use in cosmetics, Hyaluronic Acid was primarily utilized in medicine for its wound healing properties. It was employed to treat wounds and scars due to its ability to stimulate new cell growth and provide necessary hydration to the skin. This medicinal background highlights its effectiveness as a hydrating and regenerative agent.
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