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| Catalog Number | CI-GU-0016 |
| Product Name | Hexylresorcinol |
| CAS | 136-77-6 |
| Structure |  |
| Synonyms | 1,3-Benzenediol, 4-hexyl-;Hexylresorcinol |
| IUPAC Name | 4-hexylbenzene-1,3-diol |
| Molecular Weight | 194.27 g/mol |
| Molecular Formula | C12H18O2 |
| InChI | InChI=1S/C12H18O2/c1-2-3-4-5-6-10-7-8-11(13)9-12(10)14/h7-9,13-14H,2-6H2,1H3 |
| InChI Key | WFJIVOKAWHGMBH-UHFFFAOYSA-N |
| Boiling Point | 333-335 °C |
| Melting Point | 65-67 °C |
| Purity | 95% |
| Density | 1 g/mL |
| Appearance | Solid |
| Highest Usage In Residency Products | 0.01 |
| Isomeric SMILES | CCCCCCC1=C(C=C(C=C1)O)O |
Hexylresorcinol, known chemically as 4-hexylresorcinol, is widely incorporated into skincare formulations due to its numerous advantageous properties. It functions effectively as an antiseptic and local anesthetic, while also enhancing skin regeneration. This compound exhibits significant antimicrobial activity, contributing to prolonged product shelf-life. By inhibiting the enzyme tyrosinase, Hexylresorcinol reduces melanin production, resulting in a lighter and more even skin tone. Furthermore, it promotes the action of growth factors, which accelerates cell renewal, facilitates wound healing, and improves angiogenesis and microcirculation. Importantly, Hexylresorcinol bolsters the skin's defense against oxidative stress by increasing Glutathione levels through the activation of its recovery enzymes, thereby enhancing the skin's protective mechanisms against UV exposure.
Is Hexylresorcinol safe for use on the skin?
Yes, Hexylresorcinol is considered safe for skin use. It has GRAS (Generally Recognized As Safe) status and has been used historically as a topical skin and mucosal disinfectant for treating superficial wounds. It is a component in various soaps, hand washes, and skin cleaners. Additionally, safety tests conducted by Sytheon, including Human Repeat Insult Patch Tests (HRIPT) and skin scarification tests, indicate that Hexylresorcinol is neither a primary irritant nor a primary sensitizer, even at higher concentrations.
What are the common applications of Hexylresorcinol?
Hexylresorcinol is utilized in several applications. It is effective for use in throat lozenges and as an anti-browning agent, particularly in shrimps. It also appears in various pharmacopeias around the world, including those of Australia, the US, the UK, Finland, the Netherlands, and Ireland, highlighting its antiseptic properties.
Has Hexylresorcinol been approved by regulatory bodies for certain uses?
Yes, the European Commission, Health & Consumer Protection Directorate-General, has found 4-hexylresorcinol toxicologically acceptable for the prevention of melanosis in shrimps.
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