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| Catalog Number | CI-BP-0048 |
| Product Name | Hexapeptide-2 (skin lightening peptide) |
| Purity | 0.95 |
| Appearance | White powder |
Hee Je Shin, et al. Scientific Reports, 2022, 12, 10853.
This work evaluated the hydrophobic peptide MTD 1067 as a cell penetrating peptide (CPP) to transport protein cargos of various sizes such as growth hormone-releasing hexapeptide-6 (GHRP-6) and other growth factors [des(1-3)IGF-I and PDGF-BB] via transdermal application. Of them, GHRP -6 is referred to in the cosmetics industry as hexapeptide-2 (HP-2) and is now employed as an active ingredient for skin whitening by using its melanogenesis inhibition role as an -melanocyte stimulating hormone (-MSH) antagonist.
· Synthesis of MTD 1067-bound GHRP-6
The peptides GHRP-6 and MTD-GHRP-6 were chemically synthesized using the SPPS-peptide synthesis method. The purity of GHRP-6 and MTD-GHRP-6 was 97.67% and 96.55%, respectively, and the molecular weights of the final synthetic peptides were 873.3 Da and 1898.7 Da, respectively.
· Enhanced Effects
Compared to the original cargo, MTD 1067-bound GHRP-6 exhibited the same or enhanced biological activity. Compared to the control group without MTD, the level of MTD-GHRP-6 detected in the dermis was 4.4 times higher, with no cytotoxicity exhibited. MTD 1067-bound GHRP-6 can be used to develop cosmetic and pharmaceutical functional macromolecules with enhanced transdermal permeability.
Mendoza Marí, Yssel, et al. Plastic Surgery International, 2016, 1, 4361702.
CD36, as one of the growth hormone releasing peptide 6 (GHRP-6, also known as hexapeptide-2) receptors, is present in large quantities in the granulation tissue of skin wounds. This work investigated the healing response in the presence of GHRP-6 as a CD36 agonist. Correlative experimental evidence supports the hypothesis that a GHRP-6/CD36-mediated anti-inflammatory and anti-fibrotic loop exists that appears to improve wound closure and aesthetics.
· Evaluation Methodology
Excisional full-thickness wounds (6 mmØ) were made on the back of Wistar rats and topically treated twice daily for 5 days. A universal model of rabbit ear hypertrophic scarring was implemented, with animals treated daily for 30 days. Treatment for both species was based on a sodium carboxymethylcellulose (CMC) jelly composition containing GHRP-6 400 μ g/mL.
· Experimental Results
Experiments in rats have shown that GHRP-6 pharmacodynamics involve attenuation of immune-inflammatory mediators and their effector cells, as well as a reduction in the expression of profibrotic cytokines. Importantly, in a hypertrophic scar rabbit model, GHRP-6 intervention significantly reduced the occurrence of hypertrophic scars by activating PPARγ and reducing the expression of profibrotic cytokines.
What is Hexapeptide-2, and what are its primary purposes?
Hexapeptide-2 is a synthetic peptide made up of amino acids, specifically alanine, histidine, lysine, phenylalanine, and tryptophan. It primarily serves as a skin-conditioning agent in cosmetic products. Its key purposes include reducing the appearance of aging and lightening the skin. By binding to the naturally occurring α-MSH in your body, which stimulates skin pigmentation, Hexapeptide-2 effectively reduces melanin synthesis, helping to decrease the melanin in skin cells that causes dark spots.
How does Hexapeptide-2 contribute to skin lightening?
Hexapeptide-2 helps lighten the skin by interfering with the action of α-MSH, a neuropeptide that promotes melanin production. By binding to α-MSH, Hexapeptide-2 reduces melanin synthesis, which diminishes the pigmentation in skin cells responsible for dark spots. This mechanism helps achieve a brighter skin tone and addresses issues like hyperpigmentation.
Can Hexapeptide-2 improve signs of aging, such as fine lines and wrinkles?
Yes, Hexapeptide-2 has been demonstrated in clinical studies to have anti-aging effects, including the improvement of fine lines and wrinkles. Its ability to bind with α-MSH not only reduces melanin production but also contributes to skin brightening and helps in diminishing skin redness, leading to a more youthful and radiant appearance.
Is Hexapeptide-2 safe for all skin types?
While Hexapeptide-2 is generally considered safe for topical application, it is important for individuals with sensitive skin or specific allergies to test the product on a small area before full application. As with any skincare product, it is advisable to consult a dermatologist to ensure compatibility with your skin type and conditions.
How should Hexapeptide-2 be used within a skincare routine for optimal results?
For optimal results, incorporate Hexapeptide-2 into your skincare routine by applying it after cleansing and toning but before moisturizing. Use the product consistently, following the manufacturer's instructions regarding frequency and dosage. Regular use is often necessary to observe significant improvements in skin tone and texture.
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