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| Catalog Number | CI-BP-0111 |
| Product Name | Hexapeptide-42 |
| Purity | 0.95 |
| Appearance | White powder |
| Storage | -15~-20 °C |
| Safety | No heavy metals, no skin and eye irritation |
Hexapeptide-42 is a carefully designed synthetic peptide known for its capability to activate Caspase-14, an enzyme exclusively found in the epidermis that plays a crucial role in the metabolism of Filaggrin. This peptide's actions include safeguarding against UVB-induced DNA damage while promoting natural repair processes and cornification, thereby maintaining DNA integrity and enhancing the skin's barrier function. Filaggrin, a protein rich in natural moisturizing factors, delivers profound hydration by attracting water molecules through its metabolites. Caspase-14 notably facilitates the conversion of Profilaggrin into Filaggrin during the final stages of keratinocyte differentiation. By precisely targeting Caspase-14, Hexapeptide-42 effectively boosts skin hydration, provides UVB protection, and fortifies the skin barrier. When applied in skincare, it serves as a multifunctional anti-aging solution that combats the effects of photoaging, dehydration, and skin thinning.
What is Hexapeptide-42 and how does it work?
Hexapeptide-42 is a synthetic peptide known for its sequence Ile-Gln-Ala-Cys-Arg-Gly-NH2. It specifically activates Caspase-14, a proteolytic enzyme located in the epidermis. This enzyme is crucial for the metabolism of Filaggrin, a protein that significantly aids in skin hydration by forming natural moisturizing factors (NMFs). By promoting Filaggrin metabolism and improving the skin barrier function, Hexapeptide-42 effectively enhances skin hydration, protects DNA from UVB-induced damage, and acts as a multifunctional anti-aging agent.
How does Hexapeptide-42 contribute to skin hydration?
Hexapeptide-42 contributes to skin hydration through its activation of Caspase-14, which aids in converting Profilaggrin into Filaggrin. Filaggrin's metabolites capture water molecules, thus providing a substantial internal hydration effect within the epidermis. This action enhances the natural levels of moisturization and supports the skin's overall hydration.
What benefits does Hexapeptide-42 offer in terms of protection against UVB damage?
Hexapeptide-42 aids in preventing UVB-induced DNA damage by stimulating repair mechanisms and supporting the cornification process. Its ability to preserve DNA integrity under UVB exposure makes it an effective ingredient for photo-protective and anti-aging skin care applications.
In what type of skincare products is Hexapeptide-42 typically incorporated?
Hexapeptide-42 is often incorporated into various skincare products that aim to provide anti-aging benefits. It is used in formulations targeting photoaging, dehydration, and skin thinning due to its multifunctional properties in improving skin barrier function and promoting DNA protection and repair.
Why is Caspase-14 a significant target for the action of Hexapeptide-42?
Caspase-14 is a significant target for Hexapeptide-42 because it is exclusively expressed in the epidermis and plays a key role in the enzymatic conversion of Profilaggrin to Filaggrin during the terminal differentiation of keratinocytes. This process is vital for enhancing skin hydration and maintaining a healthy barrier function, which are essential for youthful and resilient skin. Hexapeptide-42's biomimetic approach, targeting Caspase-14, ensures that it addresses specific pathways involved in skin health and protection.
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