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Hexanoyl dipeptide-3 norleucine acetate

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Catalog Number	CI-BP-0067
Product Name	Hexanoyl dipeptide-3 norleucine acetate
CAS	860627-90-3
Structure
Synonyms	(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-(hexanoylamino)pentanoyl]amino]propanoyl]amino]hexanamide
IUPAC Name	acetic acid;(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-(hexanoylamino)pentanoyl]amino]propanoyl]amino]hexanamide
Molecular Weight	515.66 g/mol
Molecular Formula	C23H45N7O6
InChI	InChI=1S/C21H41N7O4.C2H4O2/c1-4-6-8-12-17(29)27-16(11-9-13-25-21(23)24)20(32)26-14(3)19(31)28-15(18(22)30)10-7-5-2;1-2(3)4/h14-16H,4-13H2,1-3H3,(H2,22,30)(H,26,32)(H,27,29)(H,28,31)(H4,23,24,25);1H3,(H,3,4)/t14-,15-,16-;/m0./s1
InChI Key	VZFVSUWDAQRRET-NLQWVURJSA-N
Purity	0.95
Appearance	White powder
Storage	-15~-20 °C
Isomeric SMILES	CCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCC)C(=O)N.CC(=O)O
Safety	No heavy metals, no skin and eye irritation

Product Overview

Hexanoyl Dipeptide-3 Norleucine Acetate functions as an advanced exfoliating agent, leveraging its biomimetic tripeptide structure to enhance the skin's natural desquamation process. By occupying the binding sites of proteins known as desmosomes, which facilitate cell adhesion in the epidermis, this synthetic peptide effectively mimics specific amino acid sequences found in desmosomal cadherins, such as the "RAL" triplet in Desmocollin. This action prevents the connection with Desmoglein's "YAT" site, thus accelerating the shedding of corneocytes. The inclusion of hexanoic acid at the tripeptide's N-terminus significantly improves its stability, lipophilicity, and penetration into the skin's stratum corneum, allowing for its encapsulation in liposomes to enhance delivery. The substitution of leucine with norleucine in its sequence not only increases hydrophobicity but also provides resistance against proteolytic enzymes. This stability and efficacy make Hexanoyl Dipeptide-3 Norleucine Acetate a valuable ingredient in high-end exfoliating, peeling, and cleansing products.

Custom Q&A

What is Hexanoyl Dipeptide-3 Norleucine Acetate?

Hexanoyl Dipeptide-3 Norleucine Acetate is a synthetic biomimetic tripeptide that enhances the skin's natural desquamation process. It acts as a "smart" exfoliating agent by mimicking specific protein structures to facilitate controlled exfoliation.

How does Hexanoyl Dipeptide-3 Norleucine Acetate function in skincare?

This peptide occupies the binding site of desmosomes, specialized proteins responsible for epidermal cell adherence. By mimicking the Cell Adhesion Recognition (CAR) sites found on cadherins-proteins that ensure cell adhesion-it prevents these sites from forming links between corneocytes, thereby speeding up skin desquamation without causing irritation.

What makes Hexanoyl Dipeptide-3 Norleucine Acetate beneficial for the skin?

It specifically mimics the "RAL" triplet found in Desmocollin proteins to prevent their binding with Desmoglein's "YAT" sites, effectively aiding in the natural exfoliation of the skin. The replacement of Leucine with Norleucine in its structure enhances hydrophobicity and resistance to skin enzymes, improving its effectiveness and durability.

Why is hexanoic acid conjugated with Hexanoyl Dipeptide-3 Norleucine Acetate?

The conjugation with hexanoic acid increases the peptide's stability and lipophilicity, which aids in its penetration into the deeper layers of the skin, specifically the stratum corneum. This modification also allows it to be encapsulated in liposomes for enhanced delivery in skincare formulations.

Is Hexanoyl Dipeptide-3 Norleucine Acetate safe for regular use in cosmetic products?

Yes, Hexanoyl Dipeptide-3 Norleucine Acetate is considered a stable, effective, and safe ingredient for use in high-end exfoliators, peeling preparations, and cleansing products. Its design ensures targeted action while maintaining the skin's integrity.

What types of skincare products commonly contain Hexanoyl Dipeptide-3 Norleucine Acetate?

This peptide is often found in luxury exfoliating products, peeling formulations, and advanced cleansing solutions due to its intelligent exfoliating capabilities and its role in promoting healthy skin renewal.

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