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| Catalog Number | CI-HC-0203 |
| Product Name | Gluconolactone |
| CAS | 90-80-2 |
| Structure |  |
| Synonyms | D-Gluconic acid-delta-lactone;D-Glucono-1,5-lactone;Glucono delta-lactone |
| Description | Gluconolactone is a type of sugar acid that is derived from glucose. It is also known as glucono delta-lactone or GDL. It is a white, crystalline powder with a slightly sweet taste and is soluble in water. Gluconolactone is used in cosmetics and personal care products as a pH adjuster, as well as in skin care products as an exfoliant and moisturizer. It is also used in pharmaceutical formulations as an excipient, such as in tablets and capsules. Gluconolactone is a mild acid and is often used in combination with other acids, such as alpha and beta hydroxy acids, to provide a gentle exfoliation of the skin. It also has antioxidant properties and can help to brighten and even out the skin tone. |
| IUPAC Name | (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one |
| Molecular Weight | 178.14 g/mol |
| Molecular Formula | C6H10O6 |
| Canonical SMILES | C([C@@H]1[C@H]([C@@H]([C@H](C(=O)O1)O)O)O)O |
| InChI | PHOQVHQSTUBQQK-SQOUGZDYSA-N |
| InChI Key | InChI=1S/C6H10O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-5,7-10H,1H2/t2-,3-,4+,5-/m1/s1 |
| Boiling Point | 230 °C |
| Melting Point | 160 °C(dec.)(lit. |
| Appearance | white crystalline powder that is odorless and tasteless |
| Application | 1. Skin care: Gluconolactone is used in skin care products such as lotions, creams, and facial cleansers as an exfoliant and moisturizer. It helps to remove dead skin cells, unclog pores, and improve skin texture and tone. 2. Hair care: Gluconolactone is used in hair care products such as shampoos and conditioners to improve hair texture and shine. It also helps to control dandruff and other scalp conditions. 3. Food industry: Gluconolactone is used as a food additive and acidity regulator. It is commonly found in dairy products, processed fruits and vegetables, and meat products. 4. Pharmaceutical industry: Gluconolactone is used as an excipient in the production of pharmaceutical and medical products. It is used as a stabilizer, buffer, and chelating agent. 5. Industrial applications: Gluconolactone is used in the production of cement and other construction materials as a set retarder. It is also used in the textile industry as a softener and sizing agent. |
| Features And Benefits | 1. Provides gentle exfoliation 2. Hydrates and moisturizes the skin 3. Acts as a PH adjuster, balancing the acidity of the formulation 4. Helps to improve skin texture and tone 5. Has antioxidant properties to protect the skin from environmental stressors 6. Enhances the delivery of other active ingredients in the formulation. |
| pH | 3.6 (10g/l, H2O, 20 °C) |
What is Gluconolactone and how does it benefit the skin?
Gluconolactone is a type of polyhydroxy acid (PHA), known for being as effective as alpha hydroxy acids (AHAs) but less sensitizing. It offers benefits such as evening skin tone, providing anti-aging effects, and enhancing hydration. Its larger molecular structure limits skin penetration, reducing the risk of irritation while still maintaining its effectiveness.
How does Gluconolactone differ from other exfoliants like AHAs?
Unlike AHAs such as glycolic acid or lactic acid, Gluconolactone has a larger molecular size, which means it penetrates the skin less deeply. This can result in fewer sensitizing side effects for those with sensitive skin, while still providing effective exfoliation and promoting skin surface strength.
Is Gluconolactone suitable for all skin types?
Gluconolactone is generally considered suitable for all skin types, especially sensitive skin, due to its less sensitizing nature. However, as with any skincare product, it is advisable to conduct a patch test first to ensure tolerance.
Can Gluconolactone be used with other skincare products?
Yes, Gluconolactone can be integrated into most skincare routines. Due to its antioxidant properties, it may complement other skincare products well, enhancing the overall benefits of your regimen. However, it's always recommended to consult with a dermatologist to tailor the best skincare routine for your needs.
How does Gluconolactone support anti-aging?
As an exfoliant, Gluconolactone helps in removing dead skin cells, which can lead to a more even skin tone and a reduction in the appearance of fine lines and wrinkles. Additionally, its hydrating properties contribute to plumper, more youthful-looking skin.
Is there any research supporting the effectiveness of Gluconolactone?
According to Dr. Mark G. Rubin, a board-certified dermatologist, research demonstrated only a minor reduction in dermal penetration for Gluconolactone compared to glycolic acid, indicating its comparative effectiveness. While it may be slightly less sensitizing, it is not a significantly dramatic improvement over other AHAs.
How should Gluconolactone be incorporated into a skincare routine?
Gluconolactone can be used once or twice daily, depending on your skin's tolerance and the product's specific instructions. It's often found in serums, creams, and lotions. Consistent use can yield optimal results in improving skin tone and hydration.
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