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| Catalog Number | CI-FC-0064 |
| Product Name | Glucamine |
| CAS | 488-43-7 |
| Structure |  |
| Synonyms | (2R,3R,4R,5S)-6-Aminohexane-1,2,3,4,5-pentaol |
| IUPAC Name | (2R,3R,4R,5S)-6-aminohexane-1,2,3,4,5-pentol |
| Molecular Weight | 181.19 g/mol |
| Molecular Formula | C6H15NO5 |
| InChI | InChI=1S/C6H15NO5/c7-1-3(9)5(11)6(12)4(10)2-8/h3-6,8-12H,1-2,7H2/t3-,4+,5+,6+/m0/s1 |
| InChI Key | SDOFMBGMRVAJNF-SLPGGIOYSA-N |
| Boiling Point | 314.29 °C |
| Melting Point | 126-128 °C |
| Purity | 0.98 |
| Density | 1.32 g/mL |
| Appearance | White to pale yellow solid |
| Isomeric SMILES | C([C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)N |
Glucamine, an organic primary amine structurally linked to sugar, is widely utilized for the neutralization of carbomers and acrylate polymers in cosmetic and pharmaceutical applications. This facilitates the production of transparent and stable gels. Glucamine offers a gentler and safer alternative with higher skin compatibility compared to traditional inorganic alkalizing agents like ammonia and sodium hydroxide, as well as other amines such as diethanolamine (DEA) and triethanolamine (TEA). Its unique composition, connected to the sugar Sorbitol (d-glucitol), ensures that it does not react with N-nitrosating agents, which can otherwise form carcinogenic intermediates with secondary and tertiary amines, presenting potential irritants for sensitive or mature skin. Unlike sodium hydroxide, which can cloud gels with precipitates when used as an alternative to TEA in alcohol-based formulations, Glucamine overcomes these typical challenges and allows for the production of clear and viscous gels. It is employed extensively in neutralizing formulations for creams, lotions, facial masks, baby care products, and eye care applications, generally in concentrations ranging from 0.1% to 0.8%. Glucamine is added directly in its powder form, maintaining the formulation's viscosity, unlike liquid alkalizers. However, it is not suitable for neutralizing alpha and beta hydroxy acids.
What is Glucamine used for in cosmetic and pharmaceutical products?
Glucamine is primarily used for the neutralization of carbomers and acrylate polymers in cosmetic and pharmaceutical formulations, enabling the creation of transparent and stable gels. It is often used in creams, lotions, facial masks, baby care, and eye care applications due to its gentle nature and compatibility with the skin.
How does Glucamine compare to other alkalizing agents?
Glucamine is considered gentler and safer than many inorganic alkalizing agents like ammonia and sodium hydroxide, as well as other amines such as DEA and TEA. Unlike these alternatives, Glucamine does not form potentially carcinogenic intermediates when exposed to N-nitrosating agents, offering a safer option for sensitive or aging skin.
What advantages does Glucamine offer in gel formulations?
Glucamine enables the production of clear and stable gels, unlike sodium hydroxide which can form precipitates that cloud the gel. It provides mild alkalization without altering the gel's viscosity, which is a common issue with liquid alkalizers. This makes Glucamine especially valuable in maintaining the desired consistency and appearance of gel formulations.
In what concentration is Glucamine typically used?
Glucamine is typically used in concentrations ranging from 0.1% to 0.8% in formulations, depending on the required level of alkalization. It is added in powder form, which helps maintain the final viscosity of the product.
Are there any limitations to using Glucamine in formulations?
Glucamine is not suitable for the neutralization of alpha and beta hydroxy acids. Its alkalizing properties are mild and may not be effective in formulations that heavily rely on these compounds.
Why is Glucamine considered beneficial for sensitive skin applications?
Glucamine's gentle composition, coupled with its reduced risk of forming irritating or carcinogenic by-products, makes it particularly suitable for formulations designed for sensitive or older skin. This property makes it an ideal choice for products like baby care and eye care items.
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