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| Catalog Number | CI-FC-0021 |
| Product Name | Dextran |
| CAS | 9004-54-0 |
| Synonyms | Poly[(1,6)-alpha-D-glucose] |
| IUPAC Name | 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal |
| Molecular Weight | 396.43 g/mol |
| Molecular Formula | C17H32O10 |
| InChI | InChI=1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2 |
| InChI Key | FZWBNHMXJMCXLU-UHFFFAOYSA-N |
| Melting Point | 483 °C |
| Purity | 0.98 |
| Appearance | White to pale beige solid |
| Isomeric SMILES | C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC(C(C(C(C=O)O)O)O)O)O)O)O)O)O)O)O |
Dextran, a polysaccharide derived from glucose units with α-C1-C6 linkages, varies in chain length from short, water-soluble forms to long, insoluble ones. Originally a byproduct of the sugar production process caused by bacteria such as Lactobacillus, Leuconostoc, and Streptococcus, dextran's potential has been harnessed for beneficial uses. Recent innovations by Pierre Monsan's team at LISBP-INSA in Toulouse have led to the development of glucan-saccharases, such as DSR-S, which efficiently convert sucrose into dextran with controlled molecular weight and diverse structures. This environmentally-friendly production method extends dextran's application across various industries, including cosmetics, biomedical, and chemicals. It is valued for its biocompatibility, ability to control viscosity, and its role as an active ingredient for water retention and cell growth stimulation in tissue regeneration. Additionally, dextran serves as a biopolymer for encapsulating other active ingredients and as an alternative to synthetic polymers.
What are the primary benefits of Dextran for the skin in cosmetic formulations?
Dextran offers several key benefits in skincare products. It serves as a thickening agent that helps control the viscosity of formulas. Additionally, Dextran stabilizes emulsions, improves the biocompatibility of products, and enhances the delivery of other active ingredients. Its moisturizing properties aid in water retention, and it actively stimulates cell growth, boosts tissue regeneration, balances skin microbiota, and protects other constituents within the formulation.
How does Dextran improve the stability and biocompatibility of skincare formulations?
As a stabilizer, Dextran helps maintain the uniformity of emulsions, ensuring that the components of a skincare product remain well-mixed. Its biocompatibility makes it an excellent choice for sensitive skin applications, promoting a gentle and effective interaction between the product and the skin.
In what way does Dextran contribute to moisture retention in the skin?
Dextran acts as a humectant, drawing moisture from the environment into the skin. This capability helps retain water in the epidermis, maintaining hydration levels and ensuring that the skin remains supple and plump.
Can Dextran aid in skin regeneration and repair?
Yes, Dextran has properties that stimulate cell growth and tissue regeneration. By providing energy to skin cells, it supports natural repair processes, enhancing the skin's ability to heal and renew itself effectively.
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