Our customer service representatives are available 24 hours a day, from Monday to Sunday.
| Catalog Number | CI-SC-0567 |
| Product Name | Bakuchiol |
| CAS | 10309-37-2 / 7732-18-5 |
| Synonyms | 4-(3-Ethenyl-3,7-Dimethyl-1,6-Octadienyl)Phenol |
| Description | Retinol-like, 100% natural, anti-aging & anti-blemished skin compound extracted from the edible seeds of the Psoralea Corylifolia plant, a herb that is widely used in Indian as well as in Chinese medicine. Despite having no structural resemblance to retinol, Bakuchiol was found to have retinol functionality through retinol-like regulation of gene expression. > 99% purity. Molecular weight 256.38g/mol. Specific gravity <1.0. |
| Molecular Weight | 256.4 g/mol |
| Molecular Formula | C18H24O |
| Canonical SMILES | CC(=CCC[C@@](C)(C=C)/C=C/C1=CC=C(C=C1)O)C |
| Boiling Point | 391.38 °C (Predicted) |
| Purity | 97% |
| Solubility | Water-insoluble. Soluble in alcohol, DMSO, plant oils, triglyceride, silicone oils, and a wide-range of hydrophobic emollients. |
| Appearance | Light yellow to brown viscous liquid. |
| Application | Anti-blemish skin products, face creams, lotions, anti-aging & anti-wrinkle products. |
| Storage | Store at room temperature |
| Composition | Bakuchiol, water |
| Features And Benefits | Effective active agent against blemished and impure skin.Balances natural regulation of sebum production.Bakuchiol has anti-aging and anti-wrinkle properties by having retinol-like activities. Bakuchiol has been clinically demonstrated to reduce hyperpigmentation and wrinkles as efficiently as retinol.In in-vitro studies Bakuchiol has been found to stimulate collagen production and maintain the high level of elastin.Bakuchiol has excellent photochemical and hydrolytic stability and acts as stabilizer of retinol under photo-oxidative environment.In-vitro, Bakuchiol has anti-bacterial and anti-fungal activity. |
| GMO | GMO-free |
| HS Code | 3504001000 |
| INCI | Bakuchiol |
| Manufacture | Bakuchiol is extracted and purified from the seeds of the Psoralea corylifolia plant. |
| pH | see long description |
| Raw Material Source | Edible seeds of the Psoralea Corylifolia plant |
| Refractive Index | 1.56 (Predicted) |
| Uses | Add to the oil phase of emulsions. Do not heat to more than 50°C (122°F). Typical use level: 0.25 to 1%. Addition of a small amount of a chelating agent (e.g. 0.05% EDTA) is helpful in overcoming coloration issue due to the presence of iron or copper. pH of final product should be < 6.0. For external use only. |
Bakuchiol is a natural compound extracted from the seeds and leaves of the Psoralea corylifolia plant, and has been traditionally used in oriental medicine. This phenolic compound is recognized as the first natural alternative to retinol, offering similar anti-aging benefits without close structural resemblance to retinol itself. Notably, Bakuchiol effectively reduces hyperpigmentation and dark spots diminishes fine lines and wrinkles, and provides protection against free radical damage. It boasts impressive photochemical and hydrolytic stability and a favorable safety profile, making it suitable for various formulations due to its compatibility with numerous emollients and solubilizers. Empirical evidence from DNA microarray qtPCR cell culture and enzyme inhibitory activity studies as well as in vitro and in vivo research, particularly in acne-prone skin highlights, Bakuchiol's potential as a key ingredient in dermatological and skincare products. Preliminary findings suggest that Bakuchiol could replicate the skin-enhancing effects of retinol, avoiding its side effects thus potentially advancing the pursuit of youthful skin.
Mascarenhas-Melo, Filipa, et al. Phytochemistry Reviews, 2024, 1-37.
The major skin bioactivities of bakuchiol include antifungal, antibacterial, antioxidant, anti-inflammatory, anti-aging, depigmenting, and anti-cancer. Various formulations containing bakuchiol as a cosmetic ingredient have been developed for reducing fine lines and wrinkles, improving skin elasticity, increasing collagen synthesis, even skin tone, etc.
However, the special physicochemical properties of bakuchiol require and benefit from the development of innovative skin delivery systems to encapsulate it. For example, Wadakwa et al. explored a novel approach to deliver P. corylifolia (Babchi) (BO, of which bakuchiol is the main component) essential oil to the skin by encapsulating it in microsponges (MS). Furthermore, photodegradation studies showed that BOMS were more photostable than free BO, which was attributed to the physical barrier formed by the encapsulation of BO in the MS system.
Kumar et al. focused on encapsulating BO in β-cyclodextrin (β-CD) (β-CDNS)-based nanosponges (NS) (BONS). Nanocavities within the solid network of β-CD can encapsulate complex chemistries. NS are generally highly efficient and can significantly improve stability.
Putriana, Norisca Aliza, et al. Preprints, 2024, 2-14.
The antioxidant and anti-aging properties of bakuchiol match those of retinol paired with anti-inflammatory benefits. Retinol stands as a proven anti-aging skin treatment but can lead to irritation and sensitivity issues for certain users. Bakuchiol offers a more delicate solution for individuals who have sensitive skin types.
Many products advertise it as a solution for diminishing fine lines and wrinkles along with other aging skin symptoms. Bakuchiol reportedly enhances skin texture while boosting firmness and elasticity. Bakuchiol benefits skin by providing anti-aging effects and treating pigmentation, while also serving as an antioxidant and anti-inflammatory agent alongside its anti-acne and anti-melanogenesis properties. The market offers bakuchiol-based cleansers, serums, nanoemulsions and creams.
Bakuchiol water-in-oil nanoemulsion structures have been reported to improve the transdermal delivery of bakuchiol. In vivo tests demonstrated that Bakuchiol improved skin penetration while also enhancing anti-aging benefits and moisturizing effects along with skin regeneration. This product functions as a sustainable solution which presents minimal health risks along with reduced skin irritation and photosensitivity.
The study demonstrated that Bakuchiol substantially reduced serum production of TNF-α and IL-6 when triggered by LPS infusion. The anti-inflammatory activity of Bakuchiol on activated microglia operated through the suppression of both p38 MAPK and ERK pathways.
What is Bakuchiol and where does it come from?
Bakuchiol is a natural compound derived from the Psoralea corylifolia plant, which has been used in oriental medicine. It is recognized as the first natural alternative to retinol, offering similar benefits for skincare without close structural similarities. Known for its anti-aging properties, Bakuchiol is over 99% pure and extracted from the seeds and leaves of the plant.
How does Bakuchiol compare to Retinol in terms of effectiveness?
Although Bakuchiol and Retinol differ structurally, they share a similar pattern of activity on key anti-aging genes and proteins. Bakuchiol effectively reduces hyperpigmentation and dark spots, diminishes fine lines and wrinkles, and offers protective benefits against free radical damage. Its excellent photochemical and hydrolytic stability, alongside a favorable safety profile, makes it a compelling retinol alternative for skincare.
Can Bakuchiol irritate the skin like Retinol might?
Bakuchiol is known for its good safety profile and is less likely to cause the irritation often associated with Retinol. This makes it suitable for individuals with sensitive skin who are looking for an alternative that provides similar anti-aging benefits without the typical side effects.
What are the stability and formulation benefits of using Bakuchiol in skincare products?
Bakuchiol exhibits excellent photochemical and hydrolytic stability, which allows it to maintain effectiveness over time. It is also easy to formulate due to its compatibility with various emollients and solubilizers, making it a versatile ingredient in dermatological and skincare formulations.
What are the potential benefits of Bakuchiol for acne-prone skin?
Studies, including DNA microarray and qtPCR results, have demonstrated Bakuchiol's potential benefits for acne-prone skin. In vitro and in vivo studies indicate its ability to modulate enzyme activity and deliver retinol-like effects, making it a promising ingredient for improving skin appearance and health, specifically in acne management.
If you have any questions, please contact us. You will get a satisfactory answer.
