Sodium Lauroyl Lactylate

Qin, Ziyu, et al. Journal of Molecular Liquids, 2022, 352, 118544.

Sodium lauroyl lactylate (SLL) is an anionic surfactant widely used in cosmetics, known for its low surface tension, high wettability, and effective emulsifying capabilities. This study examined the surface characteristics and applications of mixtures combining the anionic surfactant SLL with the cationic surfactant gemini quaternary ammonium salt with a hydroxyl group (GC12). The findings provide theoretical insights and technical assistance for researching SLL composite systems, broadening their potential applications in areas such as crude oil recovery, cosmetics, and medicine.
Key Findings
· The SLL/GC12 surfactant mixtures exhibit synergistic effects, resulting in enhanced surface activity and improved performance. The surface tension was minimized when the mole fraction of SLL (αSLL) was 0.4.
· Additionally, calculated interaction parameters indicated stronger attractive forces between the mixed surfactant molecules at air/solution interfaces or within mixed micelles. The wetting and emulsifying capabilities peaked when the mass fraction of SLL was 50%. Foam stability remained above 95% at mass fractions of SLL of 20%, 40%, and 50%. Furthermore, vesicle formation was most favorable at a mole fraction of SLL close to 0.5, at a total solution concentration of 3 mM.

Sguizzato, Maddalena, et al. Pharmaceutics, 2022, 14(1), 108.

This work investigated the potential of negatively charged liposomes obtained from four anionic surfactants, namely sodium docusate (SD), N-lauroyl sarcosine (NLS), Protelan AG8 (PAG), and sodium lauroyl lactylate (SLL), for the delivery of manganese-based compounds. Liposomes containing NLS or SLL were found to be the most stable over time, and the presence of manganese-based compounds did not affect their size distribution.
Preparation of liposomes
· Anionic liposomes were created using direct hydration followed by extrusion. An organic solution comprising CH2Cl2 and methanol (1:1 v/v) was prepared, containing phosphatidylcholine (PC), cholesterol (CH), and an anionic surfactant (AS) in a molar ratio of 4:2:1. This organic mixture was then evaporated under vacuum (70 bar, rotation speed 3) for 40-45 minutes, resulting in a thin film that was subsequently hydrated with water, vortexed, and sonicated for 5 minutes. During the hydration phase, manganese-based compounds (500 µM) were added either in the organic phase (MA, lipophilic) or in water (MC, hydrophilic) depending on the formulation.
· The liposomes were then extruded, yielding vesicles with a uniform size distribution by passing the liposome dispersion five times through two stacked polycarbonate filters with 0.2 µm pores, using an Extruder and applying nitrogen pressure of 10-20 bars. After this process, the liposomes were collected and stored for future studies.