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| Catalog Number | CI-SC-0607 |
| Product Name | Provitamin B5 Powder (dl-panthenol) |
| CAS | 16485-10-2 |
| Structure |  |
| Description | Provitamin B5 in powder form (synonyms: dl-pantothenyl alcohol, pantothenol, dexpanthenol) is the alcohol analog of pantothenic acid (vitamin B5). 100% pure (racemic mixture of l-panthenol and d-panthenol). |
| Solubility | Soluble in water & alcohol, not in oils |
| Appearance | White to off-white crystalline powder |
| Application | Creams, lotions, shampoos, conditioners, body washes, makeup. |
| Storage | Store light-protected at a cool and dry place |
| Composition | dl-panthenol |
| Features And Benefits | Penetrates readily into skin and hairHas good moisturizing and softening propertiesHas been shown to improve the appearance of irritated skin and is often used as rejuvenating agentGives the hair moisture and shine and reduces split ends |
| GMO | GMO-free (does not contain plant-derived components) |
| HS Code | 2936240100 |
| INCI | dl-panthenol |
| Manufacture | Panthenol is synthetically produced by combining propanolamine and beta-dimethylbutyrolactone. |
| Preservation | Preservative-free |
| Purity Grade | No purity grade applicable |
| Raw Material Source | Propanolamine and beta-dimethylbutyrolactone |
| Uses | Add to water phase of formulas, usual final concentration 0.5-5%. For external use only. |
Khater, Syame, et al. Journal of pharmaceutical and biomedical analysis, 2015, 102, 321-325.
The therapeutic effects of provitamin B5 are solely attributed to its D-form (dexpanthenol), making precise determination of its enantiomeric purity in cosmetic products essential. This study presents a swift and effective chiral supercritical fluid chromatography (SFC) method for the quantitative analysis of panthenol enantiomers in various cosmetic formulations, including creams, lotions, wipes, and exfoliants.
Determination Method
· The samples were prepared using liquid-liquid extraction followed by solid-phase extraction with amino cartridges. Various enantioselective columns were tested to reverse the elution order so that the minor enantiomer would elute first. The optimal separation of the enantiomers and the internal standard, N-acetyl-l-alanine, was accomplished on a 3 μm-amylose-type immobilized polysaccharide chiral stationary phase in under 6 minutes, using a simple mobile phase of carbon dioxide and 11% methanol, at a flow rate of 2.3 mL/min, 25 °C, and a backpressure of 150 bar.
· The technique employed supercritical fluid chromatography, paired with an optical diode-array detector and a user-friendly single-quadrupole mass spectrometer featuring an electrospray ionization source. This online coupling enhances the method's informative capacity and detection sensitivity, particularly beneficial since underivatized panthenol exhibits weak UV absorption. The limit of quantification (LOQ) was determined to be 0.5 μg/mL using single-ion recording.
Jerajani, Hemangi R., et al. Indian Journal of Dermatology, Venereology and Leprology, 2010, 76, 20.
This work quantified how a daily application of a lotion rich in niacinamide, provitamin B5 (panthenol) and tocopheryl acetate had impacted epidermal hyperpigmentation on the faces of epidermal hyperpigmentators using quantitative image analysis. Results revealed a face cream with niacinamide, provitamin B5 and tocopheryl acetate brightened skin tone and texture.
· Lotion Formulation
The hydrating lotion had 4% of niacinamide, 0.5% of provitamin B5, 0.5% of tocopheryl acetate, sunscreen, and glycerol in addition to other cosmetic ingredients in the control lotion.
· Evaluation Results
Of the 246 women who were randomised to treatment, 207 (84%) completed the study. Among the women who received the test lotion, hyperpigmentation had greatly decreased, skin tone became more even, skin lightened and skin texture improved. This changed as early as 6 weeks after treatment as compared with the control. The test lotion was well tolerated.
What is the chemical formula of Panthenol?
The chemical formula of Panthenol is C9H19NO4.
How is Panthenol stored?
Panthenol is stored in an inert atmosphere at room temperature.
What are some of the side effects of Panthenol?
In rare cases, skin irritation and contact allergies have been reported with Panthenol.
What is the main role of acetyl-co-enzyme A, which is formed from Panthenol in the body?
The main role of acetyl-co-enzyme A is to provide activated acetic acid into the citric acid cycle for energy production.
How is Panthenol used in dermatological conditions?
Panthenol is used in topical products such as ointments and lotions to relieve itching, promote healing, and increase fibroblast proliferation.
What is the mechanism of action of Panthenol in the skin?
Panthenol is converted into Pantothenic acid in the skin, which is essential for the synthesis of Acetyl Coenzyme-A, important for various biochemical reactions.
How is Panthenol used in hair care products?
Panthenol is known for its humectant properties and its ability to improve the resistance of hair to mechanical stress in hair care applications.
What safety codes and statements are associated with Panthenol?
Panthenol has hazard code Xn and risk statements 36/37/38, and safety statements 26-37-45-36/37/39.
What is the boiling point of Panthenol?
The boiling point of Panthenol is 118-120°C under a pressure of 0.02 Torr.
Why is Panthenol considered a valuable ingredient in skin care products?
Panthenol is valued in skin care for its moisturizing properties, anti-inflammatory effects, and its ability to soothe irritated and sensitive skin.
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