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| Catalog Number | CI-SC-0139 |
| Product Name | TSGD (Tetrasodium Glutamate Diacetate) |
| CAS | 51981-21-6 |
| Structure |  |
| Description | High purity, versatile and readily biodegradable chelating agent based upon L-glutamic acid, a natural and renewable raw material. Also known as GLDA chelate. Actives: 46-48%. |
| Solubility | Water-soluble |
| Appearance | Yellowish liquid, ammonia odor |
| Application | All kinds of cosmetic products like creams, lotions, shampoos, conditioners, makeup products, sunscreen products, hair colorings, powders, personal care wipes. |
| Storage | Store in a closed container at a dry place at room temperature |
| Composition | Tetrasodium glutamate diacetate, water |
| Features And Benefits | Excellent chelating effectiveness controlling metal catalyzed decompositionReduces water hardness and prevents precipitationsBoosts performance of preservatives improving shelf lifeStabilizes the pH value and is effective in wide pH rangeDoes not sensitize human skinCompletely biodegradable as compared to phosphates and phosphonatesEffective alternative to EDTA |
| GMO | GMO-free (does not contain plant-derived components) |
| HS Code | 2915290000 |
| INCI | Tetrasodium glutamate diacetate |
| Manufacture | Tetrasodium glutamate diacetate is manufactured from L-glutamic acid which is made by aerobic fermentation of sugars and ammonia. |
| Preservation | Preservative-free |
| Purity Grade | No purity grade applicable |
| Raw Material Source | L-glutamic acid |
| Uses | Typical use level 0.1-0.5%. Add at the end of formulation process or to water phase of emulsions. For external use only. |
Wei, Juan, et al. Journal of Cosmetic Dermatology, 2023, 22(9), 2605-2611.
Taking into account the sensory preferences of oily skin, a stable serum formula was developed in the form of a toner. The combination of three functional ingredients (Hedyotis diffusa leaf extract, yeast/zinc ferment and willow orchid extract) covers multiple targets for oily skin conditioning. Through further formulation design with other ingredients such as allantoin, glucoside, tetrasodium glutamate diacetate (TSGD), etc., the problems of drying and ingredient compatibility were solved.
· Oil control essence formula
Water, 1,3-butylene glycol, propylene glycol, allantoin, tetrasodium glutamic acid diacetate, capryloyl hydroxamic acid, glycerol glucoside, jasmine water, Buddleia alba leaf extract, yeast/zinc fermentation phytochemicals, willow orchid extract.
· Efficacy evaluation of essence
In vitro and clinical test results show that the essence has significant oil control and moisturizing effects. The skin oil content dropped by 21.8% after 8 hours of use, and the skin oil content dropped by 30.05% after 28 days, indicating that the essence can achieve rapid and long-lasting oil control effects. Long-term use can also relieve problems such as enlarged pores, blackheads, and whiteheads.
Pinto, Daniela, et al. Scientific Reports, 2021, 11(1), 8695.
The residual activity of cosmetic preservatives on the skin may alter the balance of the skin microbiota. This work used a 3D skin model and a culture-dependent approach to study the effects of 11 common cosmetic preservatives, including tetrasodium glutamate diacetate, and their combinations on Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus in vitro.
· Preservative combination containing tetrasodium glutamate diacetate
In preservative formula C3, it contained 96.27% water, 0.30% hydroxyacetophenone, 1.00% (phenylpropanol, propylene glycol, caprylyl glycol, tocopherol), 0.43% tetrasodium glutamate diacetate (AQUA), and 1.00% ammonium acryloyldimethyltaurate/VP copolymer.
· Preservative efficacy with tetrasodium glutamate diacetate
Formulation C3 (hydroxyacetophenone, phenylpropanol, propylene glycol, caprylyl glycol, tocopherol, and tetrasodium glutamate diacetate) modestly inhibited P. acnes and strongly inhibited S. aureus, but not S. epidermidis. Use of these preservative combinations may be beneficial for topical products for skin and scalp where restoration of a pre-existing state of microbial dysbiosis is desired.
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