Stearyl Alcohol

Djuris, J., et al. International Journal of Cosmetic Science, 2014, 36(1), 79-87.

In this O/W cosmetic emulsion formulation system, cetearyl glucoside (CG) was used as a natural, biodegradable nonionic emulsifier at a relatively low concentration (1%), while a mixture of co-emulsifiers (stearic acid, cetyl alcohol, stearyl alcohol and glyceryl stearate) was used to stabilize the formulation. In order to determine the optimal composition of the co-emulsifier mixture, a D-optimal mixture experimental design was used.
Sample preparation and experimental design
· Samples were prepared by gradually mixing the oil phase, heated to 80°C, with the water phase, which also contained the emulsifier CG and was pre-heated to the same temperature. A mechanical stirrer with a straight blade impeller was used to stir the mixture at 500 rpm for 3 minutes, followed by 800 rpm until it cooled to room temperature.
· The study focused on a four-component system made up of lipophilic co-emulsifiers: stearic acid (X1), cetyl alcohol (X2), stearyl alcohol (X3), and glyceryl stearate (X4). The total amount of co-emulsifiers in each formulation was set at 5%, with each co-emulsifier's proportion varying from 0 to 5%. This setup allowed for the examination of both pure co-emulsifiers and their combinations.
· The experimental design included 13 tests: 10 for model fitting, 2 for assessing the lack of fit, and 1 as a replicate to estimate experimental error. In this design, four experiments represented the vertices of a tetrahedron, six represented the centers of its edges, plus a center point and an axial check.

Gupta, Sumit, et al. International Journal of Research, 2023, 9(6), 353.

A skin cleanser formulated with cetyl alcohol, stearyl alcohol, glycerin, vitamin E, and colloids was evaluated for its efficacy, safety, tolerability, and usage trends in individuals with dry and sensitive skin. The skin cleanser was effective and well-tolerated among participants, providing moisturizing, soothing, exfoliating, and antioxidant benefits. It efficiently removed excess oil, dirt, dead cells, microorganisms, and sweat, offering a gentle and mild experience in daily skincare routines.
Evaluation Methods and Results
· A retrospective analysis was performed, targeting individuals aged 18 to 65 years who were diagnosed with atopic dermatitis and dry skin conditions that necessitated the use of a mild skin cleanser. A total of 568 cases were considered, with 488 cases of dry and sensitive skin being thoroughly examined over a two-week study period.
· The gentle skin cleanser demonstrated a significant decrease (p<0.0001) in skin dryness, itchiness, and irritation, with reductions of 4.42±1.92 (63.38%), 4.03±2.71 (49.38%), and 4.44±2.07 (65.58%) respectively for participants with dry skin, and 4.25±1.48 (58.49%), 3.26±3.22 (18.02%), and 4.42±1.56 (63.23%) for those with sensitive skin after consistent use. Participants reported favorable feedback and showed general satisfaction with the product used in the study.