Coco Caprylate Caprate

Gavinet B, et al. International Journal of Molecular Sciences, 2024, 25(13), 7432.

This article investigated whether two new dose forms, cream-gel and gel-oil emulsion, could enhance release diclofenac to the skin. The cream-gel and gel-oil emulsions were found to be adequate carriers for stabilizing diclofenac, but formulation adjustments resulted in different permeation properties. In the experiment, coco-caprylate/caprate was used to explore the effects of solvent removal on formula.
Tests and Results for Coco-caprylate/caprate Formulations
· In in vitro permeation testing (IVPT) 2, isopropyl myristate was replaced by coco-caprylate/caprate (CCC) alone or in combination with liquid paraffin.
· The percentage of diclofenac which penetrated into the receptor fluid after 24 hours was 10.38% in the cream-gel with a penetration enhancer (CG PG-DEGEE), 1.15% in the cream-gel with coco-caprylate/caprate and liquid paraffin (CG CCC-MO), 1.63% in the cream-gel with coco-caprylate/caprate alone (CG CCC), and 1.83% in the baseline.
· All three solvent-free cream-gels had substantially more diclofenac in the epidermis than in the baseline, while CG IPM and CG CCC both had significantly more in the dermis.
· The percentage of diclofenac that permeated into the receptor fluid at 24 hours was 5.93% for the gel-in-oil emulsion containing propylene glycol (GIO PG-CCC), 4.42% for the formulation without propylene glycol, and 1.83% for the baseline. Removal of propylene glycol from the gel-in-oil emulsion did not change the total amount of diclofenac that permeated.

Rigano L, et al. Cosmetics, 2021, 8(4), 105.

This work adopted a systematic formulation approach and uses a plant-based emollient (including coconut oil/caprate, hydrogenated olive oil unsaponifiables) to obtain a new lipstick formula. After a series of formula optimization experiments and evaluations, including the study of compatibility and thickening with wax, the dispersibility of pigments, and the impact on the sensory properties of the formulated lipstick, the final formula and preparation method are as follows:
· Using suitable equipment, pre-disperse and mill the lakes and pigments in castor oil. Heat phase A to 85 °C while stirring. In two separate containers, heat phase B (containing coco-caprylate/caprate) to 95 °C and phase C to 85 °C, also while mixing.
· Add phase C to phase B while mixing. Next, add the mixture of phases B and C to phase A, maintaining a temperature of 85 °C. Just before transferring the mixture into molds at 80 °C, incorporate ingredients D, E, and phase F.
· After 24 hours at room temperature, the formula exhibits the following chemico-physical parameters: Drop point of 68 °C and a breaking load of 210 g. The formula remained stable over two months when stored in glass jars and plastic containers at room temperature, 4 °C, and 42.5 °C. The final formulation demonstrates a superior covering effect compared to prior experiments, with a more uniform appearance.