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| Catalog Number | CI-GU-0220 |
| Product Name | Zinc Pyrithione |
| CAS | 13463-41-7 |
| Structure |  |
| Synonyms | ZPT |
| IUPAC Name | zinc;1-oxidopyridin-1-ium-2-thiolate |
| Molecular Weight | 317.7 g/mol |
| Molecular Formula | C10H8N2O2S2Zn |
| InChI | InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2 |
| InChI Key | OTPSWLRZXRHDNX-UHFFFAOYSA-L |
| Melting Point | 240 °C |
| Purity | 95% |
| Density | 1.78 g/mL |
| Solubility | Insoluble |
| Appearance | Solid |
| Isomeric SMILES | C1=CC=[N+](C(=C1)[S-])[O-].C1=CC=[N+](C(=C1)[S-])[O-].[Zn+2] |
Zinc pyrithione is widely recognized for its effectiveness as an anti-dandruff agent, frequently incorporated into shampoos, conditioners, and leave-on treatments. Its primary mode of action is as a bactericide and fungicide, specifically targeting Malassezia spp., the yeast responsible for dandruff. The compound's lipophilic coating enhances its attraction to Malassezia, thereby improving its efficacy and mitigating the adverse effects associated with shampooing, such as scalp dryness and residue accumulation. In the United States, zinc pyrithione use complies with the FDA's OTC monograph for anti-dandruff applications, allowing concentrations of 0.30 to 2.0% active ingredient in rinse-off products and 0.1 to 0.25% in non-rinse-off formulations.
What is Zinc Pyrithione, and what are its primary uses in hair care products?
Zinc Pyrithione is a widely used anti-dandruff ingredient commonly found in shampoos, conditioners, and leave-on hair products. It is known for its bactericidal and fungicidal properties, which help to combat dandruff effectively. Its ability to combat the Malassezia yeast, a primary cause of dandruff, makes it a key component in maintaining a healthy scalp.
How does Zinc Pyrithione work to prevent dandruff?
Zinc Pyrithione works by targeting Malassezia spp., a yeast-like fungus that contributes to dandruff. It is particularly effective because of its lipophilic nature, which attracts the lipid-loving Malassezia. This attraction enhances its efficacy in combating dandruff, while also mitigating some negatives of shampooing, like dry scalp and residue buildup, ensuring improved cosmetic performance.
What forms of hair care products commonly contain Zinc Pyrithione?
Zinc Pyrithione is commonly found in rinse-off products such as shampoos, where it is used at concentrations of 0.30 - 2.0% active, and in non-rinse-off applications like conditioners and leave-on treatments, where the allowable concentration ranges from 0.1 - 0.25% active. These varied formulations help in providing anti-dandruff benefits while fitting different usage preferences and needs.
Is the use of Zinc Pyrithione in hair care products regulated?
Yes, the use of Zinc Pyrithione in hair care products is regulated to ensure consumer safety. In the United States, it complies with the FDA OTC monograph for anti-dandruff applications. The FDA specifies allowable concentrations for its use in different types of products, ensuring effective yet safe anti-dandruff treatment options are available.
Can Zinc Pyrithione cause any side effects on the scalp or hair?
While Zinc Pyrithione is generally safe for use as an anti-dandruff agent, it is essential to use products as directed to minimize any potential side effects. It has been formulated to reduce issues commonly associated with shampooing, like dry scalp and residue accumulation. However, individuals with sensitive skin should consult a dermatologist if they experience any irritation or adverse reactions.
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