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| Catalog Number | CI-BP-0080 |
| Product Name | Tetrapeptide-21 |
| CAS | 960608-17-7 |
| Synonyms | Glycine, glycyl-L-α-glutamyl-L-lysyl- |
| IUPAC Name | (4S)-4-[(2-aminoacetyl)amino]-5-[[(2S)-6-amino-1-(carboxymethylamino)-1-oxohexan-2-yl]amino]-5-oxopentanoic acid |
| Molecular Weight | 389.4 g/mol |
| Molecular Formula | C15H27N5O7 |
| InChI | InChI=1S/C15H27N5O7/c16-6-2-1-3-9(14(26)18-8-13(24)25)20-15(27)10(4-5-12(22)23)19-11(21)7-17/h9-10H,1-8,16-17H2,(H,18,26)(H,19,21)(H,20,27)(H,22,23)(H,24,25)/t9-,10-/m0/s1 |
| InChI Key | CUVSTAMIHSSVKL-UWVGGRQHSA-N |
| Boiling Point | 896.1±65.0 °C |
| Purity | 0.95 |
| Density | 1.336 g/mL |
| Appearance | White powder |
| Storage | -15~-20 °C |
| Isomeric SMILES | C(CCN)C[C@@H](C(=O)NCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CN |
| pKa | 3.29±0.10 |
| Safety | No heavy metals, no skin and eye irritation |
Tetrapeptide-21, also known as GEKG-peptide, is a synthetic compound designed to mimic a specific sequence found in various extracellular matrix proteins, including collagens and elastin. This peptide has been shown to stimulate the production of essential skin components such as collagen, hyaluronic acid, and fibronectin by dermal fibroblasts, thereby enhancing skin regeneration and wound-healing processes. Tetrapeptide-21 is particularly effective in boosting the expression of genes involved in collagen synthesis, improving its production by up to 2.5 times. Additionally, it promotes the expression of genes that produce other critical extracellular matrix components, such as glycosaminoglycans. By increasing hyaluronic acid, Tetrapeptide-21 aids in water retention, enhancing skin hydration, elasticity, and volume. Moreover, the peptide supports the interlinking of ECM components like hyaluronic acid, collagen, and elastin, contributing to a more youthful and firmer skin appearance. As a safe and potent anti-aging ingredient, Tetrapeptide-21 is incorporated into skincare products to improve skin texture, reduce the appearance of fine lines and wrinkles, and decrease surface roughness.
What is Tetrapeptide-21 and how does it function in skincare?
Tetrapeptide-21 (GEKG-peptide) is a synthetic peptide that mimics a segment of the amino acid sequence found in various extracellular matrix (ECM) proteins such as collagen and elastin. It boosts the production of collagen, hyaluronic acid, and fibronectin by dermal fibroblasts. The peptide enhances the skin's regenerative and wound-healing processes by stimulating the genes responsible for these key structural components, resulting in improved skin elasticity, hydration, and a youthful appearance.
How does Tetrapeptide-21 aid in anti-aging?
Tetrapeptide-21 is scientifically proven to enhance the expression of genes related to collagen production by up to 2.5-fold. It also increases the production of glycosaminoglycans (GAGs), including hyaluronic acid, which binds water molecules to provide hydration and volume. This action diminishes the appearance of fine lines and deep wrinkles while enhancing skin texture, firmness, and smoothness.
Can Tetrapeptide-21 improve skin hydration and elasticity?
Yes, Tetrapeptide-21 significantly enhances skin hydration and elasticity by boosting hyaluronic acid production, which retains water molecules in the skin. The additional production of fibronectin glycoprotein aids in linking ECM components like collagen and elastin, further improving skin's suppleness and volume.
Is Tetrapeptide-21 safe for all skin types?
Tetrapeptide-21 is considered a safe and effective ingredient for anti-aging skincare formulations. It has been widely used to improve skin structure and condition without any known adverse effects, making it suitable for all skin types. However, as with any skincare product, a patch test is recommended to ensure compatibility with your skin.
In what types of skincare products can Tetrapeptide-21 be found?
Tetrapeptide-21 is incorporated in various skincare applications, particularly those targeting anti-aging concerns. It can be commonly found in serums, creams, and lotions formulated to enhance skin firmness, reduce wrinkles, and improve overall skin texture and appearance.
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