Sunflower Wax (CAS 1286686-34-7)

Maru, Avish D., et al. Int J Pharm Pharm Sci, 2018, 10(11), 54-9.

A series of sunflower wax-based moisturizing creams with different formulations were prepared and compared and evaluated for physicochemical parameters such as pH, particle size, spreadability, viscosity, and in vitro retention tests. The results showed that the MF5 formulation (2% stearic acid and 2% sunflower wax) showed optimized viscosity, in vitro retention, and spreadability.
Preparation procedure of moisturizing cream
· The moisturizing cream was developed from an initial prototype using triethanolamine, stearic acid, and sunflower wax, both separately and in combination. To create the oil-in-water emulsion, sunflower wax was melted at 70-80 °C, and then stearic acid, liquid paraffin, lanolin, and glyceryl monostearate were added. Separately, the aqueous phase, which included propylene glycol, isopropyl myristate, triethanolamine, glycerin, and water, was heated to the same temperature as the oil phase. The two phases were then blended slowly with continuous stirring to create a uniform mixture. Perfume was added when the temperature decreased to 35 °C, and preservatives were incorporated into the water phase before mixing.
· To enhance the moisturizing cream using sunflower wax, both stearic acid and triethanolamine were partially or entirely substituted with sunflower wax and borax, respectively, to produce a stable formulation. A 32 full factorial design was utilized to evaluate how varying concentrations of stearic acid (X1) and sunflower wax (X2) affected key attributes such as viscosity and spreadability, yielding satisfactory results.

Bharti, Deepti, et al. Gels, 2021, 7(3), 133.

Sunflower wax (SFW) and sunflower oil (SO) can be used to prepare oleogels, which are commonly used in medicine, cosmetics, food, and biomaterials. In this work, modified SFW and SO oleogels were prepared using biodegradable emulsifiers, hydrophobic (SPAN-80) and hydrophilic (TWEEN-80). The study found that adding 3 mg each of SPAN-80 and TWEEN-80 to 20 g of oleogels yields optimal structural, molecular, and thermal properties when included in 5% SFW oleogels.
Preparation procedure for oleogels
· 5% SFW is the critical gelation concentration (CGC) for SFO. Consequently, an oleogel of SFO with 5% (w/w) SFW was created as the control formulation. To prepare it, accurately measured SO and SFW were mixed in a beaker, which was then placed in a water bath at 80 °C for about 20 minutes. The mixture was heated until the wax fully dissolved, resulting in a homogeneous solution. This clear solution was allowed to cool at room temperature (25 °C) for 30 minutes to promote oleogel formation.
· Stock solutions containing 0.1% (w/w) of SPAN-80 and TWEEN-80 were made in SO, and formulations with 1 mg, 3 mg, 5 mg, and 10 mg of SPAN-80 and TWEEN-80 were prepared according to this composition. The remaining steps for developing the formulations were conducted in the same manner.