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| Catalog Number | CI-OT-0010 |
| Product Name | Retinal |
| CAS | 116-31-4 |
| Structure |  |
| Synonyms | Retinaldehyde, Vitamin A aldehyde |
| IUPAC Name | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal |
| Molecular Weight | 284.44 g/mol |
| Molecular Formula | C20H28O |
| InChI | InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ |
| InChI Key | NCYCYZXNIZJOKI-OVSJKPMPSA-N |
| Boiling Point | 367 °C |
| Melting Point | 61-63 °C |
| Purity | 95% |
| Density | 1.01 g/mL |
| Appearance | Solid |
| Highest Usage In Residency Products | 0.02 |
| Isomeric SMILES | CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C=O)/C)/C |
Kim, Jemin, et al. Journal of cosmetic dermatology 20.9 (2021): 2874-2879.
This randomized, investigator-blinded, split-face study evaluated the efficacy and safety of MLV-RAL creams (0.05% and 0.1%) versus retinol creams (0.05%/0.1%) in 23 volunteers with photoaged skin over 8 weeks. Each participant applied MLV-RAL to one facial side and retinol to the contralateral side.
Key Findings:
· The treatment with MLV-RAL creams (0.05% and 0.1%) significantly enhanced all objective parameters compared to baseline at week 8, including wrinkle depth, skin hydration, skin elasticity, and facial curved length.
· Compared to the retinol treated sides, the MLV-RAL treated sides showed significantly better improvement in wrinkle depth, skin hydration, skin elasticity, and facial curved length (p<0.05).
· No significant difference in dermal density improvement was observed between MLV-RAL and retinol treatments.
· Safety Profile: No adverse events were reported for either MLV-RAL or retinol (0.05%/0.1%) creams at both concentrations.
Rouvrais, Céline, et al. Journal of cosmetic dermatology 17.6 (2018): 1136-1143.
The study is a randomized controlled trial comparing the efficacy and tolerability of 8 weeks daily treatment with 0.1% retinaldehyde (RAL)/glycylglycine oleamide (GGO)/pre-tocopheryl cream (n = 55 women) with that of three sequential glycolic acid (GA) peels (20%, 50%, and 70%) for photoaging. The efficacy evaluation included skin replicas, image analysis, and self-assessment of wrinkles, texture, radiance, and pigmentation; tolerability evaluation was done during the entire study period.
Key Findings:
· Both treatments significantly reduced crow's feet wrinkle depth (Cream: -7.61%, P=0.0007; Peels: -4.34%, P=0.0348) and volume, wrinkle length, and fine lines (P intergroup=0.3049, NS).
· The RAL cream demonstrated superior efficacy in refining skin texture versus GA peels (Cream: -5.61%, P=0.0025; Peels: +3.54%, P=0.08; P intergroup=0.0252).
· Safety Profile: The RAL cream exhibited significantly better tolerability with fewer and milder adverse events (12-fold lower incidence of physical signs) compared to GA peels.
Conclusion: Combined with its significantly improved tolerability profile, this RAL-based cream offers a compelling alternative to chemical peels for photoaged skin management.
What are the main benefits of using retinal in skincare?
Retinal is primarily known for its powerful wrinkle-fighting abilities. It accelerates the skin's natural renewal process, making it a versatile ingredient. Regular use of retinal can significantly reduce fine lines and wrinkles, promote skin tightness and elasticity, support collagen levels for a firmer appearance, and help unify skin tone, leading to an overall improved complexion.
How does retinal differ from other retinoids like retinol and tretinoin?
Retinoids are a class of compounds derived from vitamin A, crucial for skin health. While both retinal and retinol are types of retinoids, the main difference lies in their conversion process to retinoic acid, the active form of vitamin A. Retinal requires only one step to convert into retinoic acid, making it quicker to act than retinol, which needs two steps. Tretinoin, on the other hand, is already in the form of retinoic acid, making it more potent but available only by prescription.
Is retinal suitable for beginners in retinoid use?
Yes, retinal is often considered a beginner-friendly retinoid option. It is effective yet milder than prescription-strength retinoids like tretinoin. Because it swiftly converts to its active form, it provides noticeable results while still being accessible for over-the-counter purchase. This makes it a great starting point for those new to retinoids.
What should I expect during the initial phase of using retinal?
When using retinal for the first time, you may experience a period known as retinization. During this time, your skin adjusts to the increased turnover rate induced by retinal. It's common to experience temporary effects such as flaking and mild peeling, often referred to as purging. However, these effects are typically short-lived, and with continued use, you can anticipate a smoother, more youthful complexion within a few weeks.
Can retinal be used to improve skin tone?
Absolutely. Besides its anti-aging benefits, retinal is also adept at unifying skin tone. By promoting cellular turnover, it helps to fade discolorations and even out the complexion, contributing to a more radiant and consistent skin appearance.
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