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| Catalog Number | CI-OT-0092 |
| Product Name | Potassium Glycyrrhizinate |
| CAS | 68039-19-0 |
| Synonyms | alpha-D-Glucopyranosiduronic acid, (3beta,2beta)-2-carboxy-11-oxo-3-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, potassium salt |
| IUPAC Name | potassium;(2S,3S,4S,5R,6S)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-5-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4-dihydroxyoxane-2-carboxylate |
| Molecular Weight | 861 g/mol |
| Molecular Formula | C42H61KO16 |
| InChI | InChI=1S/C42H62O16.K/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);/q;+1/p-1/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1 |
| InChI Key | YLSUMFQEBHBMQB-OOFFSTKBSA-M |
| Purity | 90% |
| Appearance | Solid |
| Highest Usage In Residency Products | 0.002 |
| Highest Usage In Rinsing Products | 0.01 |
| Isomeric SMILES | C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)[O-])O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O.[K+] |
Potassium Glycyrrhizinate, the potassium salt derived from Glycyrrhizin found in Licorice root extract, is recognized for its remarkable utility in dermatological and personal care applications. This compound, presented as a white to faintly yellow crystalline powder with a distinct sweet taste, has been substantiated through various clinical tests to effectively treat both acute and chronic dermatitis due to its potent anti-inflammatory properties. It holds a favorable safety profile, with minimal adverse effects, contributing to its widespread use in skin care formulations. Notably, Potassium Glycyrrhizinate is chemically stable and offers excellent solubility and emulsifying properties, enhancing the performance and stability of personal care products. One of its most significant applications in skincare is its ability to inhibit the hyaluronidase enzyme, which plays a role in the degradation of hyaluronic acid and the matrix of connective tissues. By hindering this enzyme's activity, Potassium Glycyrrhizinate not only mitigates inflammation and allergic reactions but also enhances skin hydration, elasticity, and smoothness by preserving hyaluronic acid levels. Consequently, it effectively reduces skin irritation, redness, and swelling, resulting in a healthier skin appearance.
What is Potassium Glycyrrhizinate and what are its primary uses in skincare?
Potassium Glycyrrhizinate, also known as Dipotassium Glycyrrhizinate, is the potassium salt of glycyrrhizin, a component found in licorice root extract. It appears as a white to faintly yellow crystalline powder and has a specific sweet taste. This ingredient is primarily used in skincare as an effective treatment for both acute and chronic dermatitis. Numerous clinical dermatological tests in Japan and worldwide have demonstrated its anti-inflammatory properties. It is especially valued for its mild action, good efficiency, and minimal adverse effects. Thus, it is commonly included in personal care products for its stability, good solubility, and emulsifying properties.
How does Potassium Glycyrrhizinate work to improve skin health?
Potassium Glycyrrhizinate works by inhibiting the hyaluronidase enzyme, which plays a critical role in decreasing hyaluronic acid levels in the skin during the inflammatory process. By acting as an antagonist to this enzyme, Potassium Glycyrrhizinate not only exerts anti-inflammatory and antiallergic effects but also preserves the skin's hyaluronic acid levels. This leads to improved moisture retention, a smoother skin surface, enhanced elasticity, and increased skin volume. Additionally, it helps to eliminate signs of irritation, redness, and edema, contributing to a healthier skin appearance.
Is Potassium Glycyrrhizinate safe for long-term use in skincare products?
Yes, Potassium Glycyrrhizinate is considered safe for long-term use in skincare products. It is known for its mild action and good efficiency, with very few adverse effects reported. In fact, its chemical stability is one of its key benefits. It remains stable under normal conditions but may decompose if exposed to temperatures over 100 degrees Celsius for extended periods. This stability makes it a reliable ingredient in various personal care formulations designed for both short-term and long-term use.
Can Potassium Glycyrrhizinate be used alongside other skincare ingredients?
Potassium Glycyrrhizinate is generally compatible with a wide range of skincare ingredients due to its chemical stability and good solubility. It can be effectively incorporated into formulations with other active agents such as indomethacin and sodium cromoglicate, which also inhibit the hyaluronidase enzyme. In fact, clinical tests have demonstrated that Potassium Glycyrrhizinate is 11 times more effective than indomethacin and 3 times more effective than sodium cromoglicate as a positive control in inhibiting this enzyme. This makes it a valuable addition to products intended to deliver potent anti-inflammatory and moisturizing benefits.
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