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| Catalog Number | CI-SC-0345 |
| Product Name | Polysorbate 60 surfactant |
| CAS | 9005-67-8 |
| Description | Polysorbate 60 is a additive and emulsifier that is used in a wide range of products including processed foods, cosmetics, and pharmaceuticals. It is a type of polyoxyethylene sorbitan fatty acid ester and is derived from sorbitol and oleic acid. Polysorbate 60 is commonly used as an emulsifier to help mix together ingredients that do not naturally mix well, such as oil and water. It can also provide texture and improve the stability of products. In cosmetics, it can be found in lotions, creams, and makeup products. |
| Appearance | yellow to light-brown oily liquid |
| Application | 1. Emulsifier: Polysorbate 60 is a commonly used emulsifier in the food industry to blend and stabilize oil and water-based products such as salad dressings, sauces, and baked goods. 2. Cosmetics: It is used as a surfactant and emulsifier in cosmetics products such as lotions, creams, and makeup products to improve their texture and consistency. 3. Pharmaceuticals: It is used as a solubilizer in pharmaceutical products such as tablets and capsules to improve the absorption of active ingredients. 4. Industrial applications: Polysorbate 60 is also used in a variety of industrial applications as an emulsifier and stabilizer, for example in the production of detergents and paints. |
| Features And Benefits | 1. Acts as an emulsifier 2. Helps improve texture and consistency of the product 3. Enhances the solubility of certain ingredients 4. Increases stability of the product 5. Improves spreadability on the skin 6. Softens and moisturizes the skin 7. Can help to reduce the formation of redness and itchiness |
Basiri, Ladan, et al. Lwt, 2017, 84, 471-478.
This paper prepared niosomes as α-tocopherol (α-Toc) carriers through thin film hydration to enhance α-Toc utilization and stability. The ideal preparation conditions of α-Toc drug-loaded vesicles were: sorbitan monostearate (Span 60): polysorbate 60(Tween 60molar ratio 3:1, -Toc concentration 4 mg/mL, surfactant : cholesterol : dicetyl phosphate (DCP) molar ratio 25:12.5:2.5.
Niosome preparation through Span 60 and Tween 60
Different forms of niosomes were produced using a modified film hydration process. The specified amount of wall matter was dissolving in 10 mL of ethanol/chloroform, in the ratio of volume to volume: 1:2. It was then evaporated the solvent under low pressure with a rotary evaporator. The water used for hydration was 7.4- pH phosphate buffered saline (PBS). To create unilamellar niosome vesicles, it was sonicated the suspension with a probe sonicator four cycles, one cycle for 180 seconds "on" and 60 seconds "off".
Chadli, Samir, et al. Journal of Dispersion Science and Technology, 2019, 40(3), 346-354.
There was a study examining how various amounts of polysorbate 60 (Tween 60) emulsifier affected water emulsions containing 5% Pistacia lentiscus oil. The recommended optimal addition amount of Tween 60 was 3.47%, and the semi-low temperature storage time had a good effect on the stability and maintenance of the emulsion.
Preparation of emulsions with Tween 60
· The oily phase, referred to as Phase A, was created by incorporating appropriate quantities of Tween 60 (at varying concentrations), stearyl alcohol (SA), cetyl alcohol (CA), and cetyl palmitate (CP) into PLFO oil. This mixture was heated to 70 °C using a water bath and stirred until the solid components fully melted. The resulting mixture was then combined with Span 60 (SP60) while maintaining the same temperature.
· Later, the liquid phase or Phase B was prepared by dissolving benzyl alcohol (BA) in distilled water. The pH of this solution was adjusted to 6 ± 0.1 using a 0.1 mol/L NaOH solution, all while gently agitating and heating it to 50 °C.
· In the final product, it was formed by slowly adding the hot oil phase (70 °C) to the aqueous phase with regular stirring until complete dissolution took place. The mixture was then homogenized with a Digital Homogenizer at 18,000 rpm for 3 minutes. The resulting emulsions produced using the TW60 emulsifier can be classified as creams. These emulsions were stored at room temperature in a dark place for 24 hours before being kept at 12 °C for a period of 4 months to facilitate the required measurements.
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