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Polysorbate 20

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Catalog Number CI-SC-0214
Product Name Polysorbate 20
CAS 9005-64-5
Synonyms Polysorbate 40 (NF);Polyoxyethylene (20) sorbitan monolaurate;polyoxyethylene sorbitan monolaurate;Tween.(TM). 20;Polysorbate (INN)
Description Emulsifying agent consisting of laurate esters of sorbitol consisting of the monoester condensed with ethylene oxide (polyoxyethylene-20 sorbitan monostearate). HLB Value: 16-17 (gives oil-in-water emulsions).
IUPAC Name 2-[2-[3,4-Bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
Molecular Weight 522.7 g/mol
Molecular Formula C32H60O10
Canonical SMILES CCCCCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO
InChI InChI=1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3
InChI Key HMFKFHLTUCJZJO-UHFFFAOYSA-N
Melting Point 98.9 °C
Flash Point 199.4ºC
Purity 98%+
Density 1.106 g/mL
Solubility Water-soluble
Appearance Yellow liquid, no or weak odor
Application Creams, salves, ointments, balms, pomades, lipsticks, mascaras, glosses.
Storage Store in a closed container at a dry place at room temperature
Composition Polysorbate-20
Features And Benefits Non-ionic emulsifier (enables water and oil to mix)Emulsifying efficacy is increased further when combined with cetyl alcohol or sorbitan stearateActs as dispersing agent and anti-static thickenerVery useful as solubilizer and stabilizer of essential oils.
GMO GMONo data available
HS Code 3402130000
INCI Polysorbate-20
Manufacture Polysorbate 20 is obtained by esterification of sorbitol with one or three molecules of a fatty acid including stearic, lauric, oleic, and palmitic acid.
Preservation Preservative-free
Purity Grade No purity grade applicable
Raw Material Source Sorbitol, vegetable oils
Refractive Index 1.4685-1.4715
Topological Polar Surface Area 133 Ų
Uses Can be added to formulas as is. Typical use level 2 - 10%. For external use only.
Custom Q&A

What is the chemical formula of Polysorbate 20?

The chemical formula of Polysorbate 20 is C26H50O10.

What are some synonyms of Polysorbate 20?

Some synonyms of Polysorbate 20 are Tween 20, Polisorbate 20, and PS 20.

What is the melting point of Polysorbate 20?

The melting point of Polysorbate 20 is 98.9 °C.

What is the main application of Polysorbate 20 in biological techniques?

Polysorbate 20 is added to buffers and reagents for immunohistochemistry in biological techniques to prevent non-specific antibody binding and enhance reagent spreading.

What are the hazard codes associated with Polysorbate 20?

The hazard codes associated with Polysorbate 20 are Xi.

What is the Odor Type associated with Polysorbate 20?

The Odor Type associated with Polysorbate 20 is alcoholic.

How is Polysorbate 20 prepared?

Polysorbate 20 is prepared by condensing the partial esters of sorbitol and its anhydrides with ethylene oxide.

What is the Health effects of Polysorbate 20 on skin?

Polysorbate 20 was reported to be a skin irritant in dermatitis patients, but not on intact skin of healthy volunteers.

What are the main uses of Polysorbate 20 in pharmaceutical chemistry?

In pharmaceutical chemistry, Polysorbate 20 is used as an excipient to stabilize emulsions and suspensions.

What are the safety considerations associated with Polysorbate 20?

Polysorbate 20 is moderately toxic by the intravenous route and mildly toxic by ingestion. It is reported to be a human skin irritant.

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