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Catalog Number | CI-SC-0214 |
Product Name | Polysorbate 20 |
CAS | 9005-64-5 |
Synonyms | Polysorbate 40 (NF);Polyoxyethylene (20) sorbitan monolaurate;polyoxyethylene sorbitan monolaurate;Tween.(TM). 20;Polysorbate (INN) |
Description | Emulsifying agent consisting of laurate esters of sorbitol consisting of the monoester condensed with ethylene oxide (polyoxyethylene-20 sorbitan monostearate). HLB Value: 16-17 (gives oil-in-water emulsions). |
IUPAC Name | 2-[2-[3,4-Bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate |
Molecular Weight | 522.7 g/mol |
Molecular Formula | C32H60O10 |
Canonical SMILES | CCCCCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO |
InChI | InChI=1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3 |
InChI Key | HMFKFHLTUCJZJO-UHFFFAOYSA-N |
Melting Point | 98.9 °C |
Flash Point | 199.4ºC |
Purity | 98%+ |
Density | 1.106 g/mL |
Solubility | Water-soluble |
Appearance | Yellow liquid, no or weak odor |
Application | Creams, salves, ointments, balms, pomades, lipsticks, mascaras, glosses. |
Storage | Store in a closed container at a dry place at room temperature |
Composition | Polysorbate-20 |
Features And Benefits | Non-ionic emulsifier (enables water and oil to mix)Emulsifying efficacy is increased further when combined with cetyl alcohol or sorbitan stearateActs as dispersing agent and anti-static thickenerVery useful as solubilizer and stabilizer of essential oils. |
GMO | GMONo data available |
HS Code | 3402130000 |
INCI | Polysorbate-20 |
Manufacture | Polysorbate 20 is obtained by esterification of sorbitol with one or three molecules of a fatty acid including stearic, lauric, oleic, and palmitic acid. |
Preservation | Preservative-free |
Purity Grade | No purity grade applicable |
Raw Material Source | Sorbitol, vegetable oils |
Refractive Index | 1.4685-1.4715 |
Topological Polar Surface Area | 133 Ų |
Uses | Can be added to formulas as is. Typical use level 2 - 10%. For external use only. |
What is the chemical formula of Polysorbate 20?
The chemical formula of Polysorbate 20 is C26H50O10.
What are some synonyms of Polysorbate 20?
Some synonyms of Polysorbate 20 are Tween 20, Polisorbate 20, and PS 20.
What is the melting point of Polysorbate 20?
The melting point of Polysorbate 20 is 98.9 °C.
What is the main application of Polysorbate 20 in biological techniques?
Polysorbate 20 is added to buffers and reagents for immunohistochemistry in biological techniques to prevent non-specific antibody binding and enhance reagent spreading.
What are the hazard codes associated with Polysorbate 20?
The hazard codes associated with Polysorbate 20 are Xi.
What is the Odor Type associated with Polysorbate 20?
The Odor Type associated with Polysorbate 20 is alcoholic.
How is Polysorbate 20 prepared?
Polysorbate 20 is prepared by condensing the partial esters of sorbitol and its anhydrides with ethylene oxide.
What is the Health effects of Polysorbate 20 on skin?
Polysorbate 20 was reported to be a skin irritant in dermatitis patients, but not on intact skin of healthy volunteers.
What are the main uses of Polysorbate 20 in pharmaceutical chemistry?
In pharmaceutical chemistry, Polysorbate 20 is used as an excipient to stabilize emulsions and suspensions.
What are the safety considerations associated with Polysorbate 20?
Polysorbate 20 is moderately toxic by the intravenous route and mildly toxic by ingestion. It is reported to be a human skin irritant.