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| Catalog Number | CI-GU-0066 |
| Product Name | Phenylethyl Resorcinol |
| CAS | 85-27-8 |
| Structure |  |
| Synonyms | 1,3-Benzenediol, 4-(1-phenylethyl)- |
| IUPAC Name | 4-(1-phenylethyl)benzene-1,3-diol |
| Molecular Weight | 214.26 g/mol |
| Molecular Formula | C14H14O2 |
| InChI | InChI=1S/C14H14O2/c1-10(11-5-3-2-4-6-11)13-8-7-12(15)9-14(13)16/h2-10,15-16H,1H3 |
| InChI Key | PQSXNIMHIHYFEE-UHFFFAOYSA-N |
| Boiling Point | 244 °C / 12mmHg |
| Melting Point | 78-79 °C |
| Purity | 95% |
| Density | 1.171 g/mL |
| Appearance | Solid |
| Isomeric SMILES | CC(C1=CC=CC=C1)C2=C(C=C(C=C2)O)O |
| pKa | 9.77±0.40 |
Phenylethyl Resorcinol is a synthesized and stable analog of natural compounds like Pinosylvin, designed to efficiently inhibit the tyrosinase enzyme involved in melanin production, thus serving as an effective agent for skin lightening and whitening. Developed through meticulous screening of compounds with comparable structures, its chemical composition and synthesis have been fine-tuned for optimal performance and stability. Available in a highly purified, white crystalline form with minimal odor, Phenylethyl Resorcinol is easily integrated into the oil phase of skincare formulations. It offers superior skin lightening and antioxidant properties compared to conventional agents such as Kojic acid, Hydroquinone, Arbutin, and Licorice extract. Notably, it is more cost-effective than Arbutin and Licorice extract, less sensitizing than Kojic acid, safer than Hydroquinone, and more effective than most traditional tyrosinase inhibitors, including AHAs and Vitamin C. Microscopic studies have demonstrated reduced melanin levels within human hair follicles after just four days of topical use. Moreover, its antioxidant capabilities are comparable to potent antioxidants like BHT and alpha-Tocopherol, showcasing its ability to effectively combat free radicals and protect skin cells from oxidative stress and photoaging. Comprehensive safety evaluations support the use of Phenylethyl Resorcinol at concentrations up to 1% in formulations, confirming it as a safe and effective ingredient devoid of the adverse effects associated with similar products.
What is Phenylethyl Resorcinol, and how does it work in skincare products?
Phenylethyl Resorcinol is a synthetic and stable compound with strong inhibitory activity against the tyrosinase enzyme, which is involved in the production of melanin. By targeting this enzyme, Phenylethyl Resorcinol effectively reduces melanin production, making it a powerful skin-lightening agent. It was developed through screening methods that identified its optimal structure and synthesis process for improved performance and stability.
How does Phenylethyl Resorcinol compare to other skin-lightening agents?
Phenylethyl Resorcinol has several advantages over classic skin-lightening agents like Kojic acid, Hydroquinone, Arbutin, and Licorice extract. It is more cost-effective than expensive ingredients like Arbutin and Licorice extract, safer than Hydroquinone, which has been associated with cytotoxicity, and more effective than most classic tyrosinase inhibitors, including AHAs and Vitamin C. Furthermore, it lacks the sensitizing, hepatotoxic, and adverse thyroid effects observed with Kojic acid.
Is Phenylethyl Resorcinol safe for use in skincare formulations?
Yes, Phenylethyl Resorcinol is considered very safe when used in normal concentrations up to 1% in formulations. The safety dossier for Phenylethyl Resorcinol is well-documented, and it does not exhibit the adverse effects associated with some similar ingredients.
What additional benefits does Phenylethyl Resorcinol offer beyond skin lightening?
In addition to its skin-lightening properties, Phenylethyl Resorcinol exhibits powerful antioxidant activity comparable to that of well-known antioxidants like BHT and alpha-Tocopherol (Vitamin E). This means that it has a potent free radical scavenging ability, offering protection to skin cells from oxidative stress and photoaging.
How should Phenylethyl Resorcinol be incorporated into skincare products?
Phenylethyl Resorcinol is a highly purified, white crystalline solid with a very low odor, making it easy to incorporate directly into the oil phase of skincare preparations. This incorporation allows it to perform effectively in delivering skin-lightening and antioxidant benefits.
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