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| Catalog Number | CI-SC-0598 |
| Product Name | Palmitoyl Tripeptide-38 |
| CAS | 128446-35-5 / 1101175-36-3 / 56-81-5 / 7732-18-5 |
| Description | Anti-wrinkle, Anti-aging peptide derived from the tripeptide KMK naturally found in collagen VI and laminin. |
| Solubility | Water-soluble |
| Appearance | Clear liquid, odorless |
| Application | Anti-aging and anti-wrinkle creams and lotions. |
| Storage | Store light-protected at a cool and dry place |
| Composition | Hydroxypropyl cyclodextrin, palmitoyl tripeptide-38, glycerin, water, gluconolactone, sodium benzoate |
| Features And Benefits | Improves appearance of skin relief, fine lines, and wrinkles from the inside particularly on the forehead and crow's feetIn-vitro studies have found a matrikine-like effect that stimulates the synthesis of six major proteins including collagen I, II, IV, fibronectin, hyaluronic acid and laminin 5 |
| GMO | GMO-free |
| HS Code | 1518004000 |
| INCI | Hydroxypropyl cyclodextrin, palmitoyl tripeptide-38 |
| Manufacture | Palmitoyl tripeptide-38 is produced synthetically from the amino acids lysine and methione sulfone. |
| Preservation | Gluconolactone, sodium benzoate |
| Purity Grade | No purity grade applicable |
| Raw Material Source | Amino acids (lysine and methione sulfone) |
| Uses | Add to formulas to the water phase. Typical concentration 2-4%. For external use only. |
Palmitoyl Tripeptide-38 is a synthetic lipopeptide known as Pal-KMO2K, exhibiting significant efficacy in enhancing skin and lip care formulations. It acts as a matrikine-mimetic peptide to stimulate the synthesis of over six crucial components of the extracellular matrix (ECM), thereby serving as an effective alternative to hyaluronic acid and collagen injections with a focus on anti-aging benefits. Developed by Sederma, this active ingredient delivers clinically validated filling and anti-wrinkle effects by targeting multiple layers of the skin, including the epidermis, dermal-epidermal junction, and dermis. As a key component in Sederma's innovative VoluLip™ and Matrixyl™ synthe'6™ complexes, Palmitoyl Tripeptide-38 offers significant improvements in skin texture and lip fullness. Through in vivo and in vitro studies, it has been shown to enhance the production of laminins, fibronectin, hyaluronic acid, and the CD44 protein in the epidermis, while promoting the synthesis of collagens I, III, and IV, fibronectin, and HA in the dermis. Additionally, it supports aquaporin production, crucial for optimal water retention and distribution in the skin, and boosts the expression of genes that reinforce the skin's lipid barrier, thus enhancing protection against environmental factors and minimizing moisture loss. Accordingly, when integrated into skin and lip care products, Palmitoyl Tripeptide-38 effectively combats signs of aging, such as fine lines and deep wrinkles, and improves skin quality, contributing to a youthful and radiant appearance.
What is Palmitoyl Tripeptide-38 and how does it work?
Palmitoyl Tripeptide-38 is renowned for its anti-aging properties and functions as a matrikine-mimetic peptide to stimulate the production of essential components of the extracellular matrix (ECM), such as collagens, hyaluronic acid, and fibronectin. This stimulation helps reinforce skin structure, providing filling and anti-wrinkle effects across multiple skin layers, including the epidermis, dermal-epidermal junction, and dermis.
What are the benefits of using Palmitoyl Tripeptide-38 in skincare?
The benefits of using Palmitoyl Tripeptide-38 include reducing the appearance of fine lines and deep wrinkles, promoting skin hydration, improving skin texture, and enhancing skin elasticity. It helps to produce a more youthful, radiant appearance and supports the skin's lipid barrier against environmental damage.
How does Palmitoyl Tripeptide-38 compare to hyaluronic acid and collagen injections?
Palmitoyl Tripeptide-38 offers a non-invasive alternative to hyaluronic acid and collagen injections. While similarly aiming to improve skin hydration and elasticity, Palmitoyl Tripeptide-38 works by stimulating the skin's natural production of ECM components, rather than injecting them directly, providing a more holistic approach to fighting signs of aging.
Is Palmitoyl Tripeptide-38 safe for everyday use?
Yes, Palmitoyl Tripeptide-38 is safe for daily use as part of a regular skincare routine. It has been clinically proven to be effective in promoting youthful-looking skin without invasive procedures. However, as with any skincare product, it is advisable to perform a patch test prior to widespread use, especially if you have sensitive skin.
What skin types can benefit from Palmitoyl Tripeptide-38?
Palmitoyl Tripeptide-38 is suitable for all skin types, including sensitive skin. Its ability to enhance the skin's natural barrier and retain moisture makes it particularly beneficial for mature or dry skin, which may require additional support in maintaining elasticity and hydration.
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