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| Catalog Number | CI-BP-0099 |
| Product Name | Palmitoyl tripeptide-28 |
| Purity | 0.95 |
| Appearance | White powder |
| Application | It smooths, firms, and refreshes the skin, exposing a healthy and youthful appearance. |
| Storage | -15~-20 °C |
| Safety | No heavy metals, no skin and eye irritation |
Palmitoyl tripeptide-28 is a sophisticated peptide compound incorporated into advanced skincare formulations for its ability to simulate the effects of Transforming Growth Factor Beta (TGF-β), a crucial element in skin health. This peptide binds to TGF beta receptor 2, which is located on the membrane of fibroblast cells, triggering the production of essential components of the extracellular matrix (ECM). By promoting ECM synthesis, it helps maintain structural integrity while concurrently inhibiting metalloproteinases (MMPs) that degrade collagen. Moreover, Palmitoyl tripeptide-28 enhances cell adhesion through the stimulation of integrins and boosts the synthesis of protease inhibitors, further preserving collagen and elastin levels. Its application results in improved skin firmness, smoothness, and overall rejuvenation, contributing to a healthier and more youthful appearance. This peptide is utilized in peptide-based formulations such as Infinitec's ECM Moduline and Sapphire Lift.
Boen, Monica, et al. The Journal of Clinical and Aesthetic Dermatology, 2020, 13(11), 13.
In this prospective, randomised, double-blind, placebo-controlled study, it was investigated the effectiveness and safety of a new serum rich in fractionated hyaluronic acid, peptides and antioxidants for neck rejuvenation. In the formulation, peptide ingredients contained palmitoyl tripeptide-28 and palmitoyl pentapeptide-4, whose main function is to regulate collagen production along with yeast lysate.
Evaluation methods and results
· The research included 31 healthy participants with moderate to severe neck wrinkles, rated at a minimum of grade 2 on the Fitzpatrick-Goldman wrinkle scale and an elasticity score of 4. Of these, 20 individuals were randomly assigned to receive the active cream and serum treatment, while 11 were allocated to receive only the vehicle in cream and serum form for a two-month period.
· Both the active treatments and the placebo demonstrated improvements in wrinkles, skin laxity, pigmentation, erythema, dryness, and overall skin texture, accompanied by high levels of patient satisfaction. Histological analysis of one of the active serum and cream samples indicated enhancements in the quality of papillary dermal collagen and an increase in the number of elastic fibers in the upper dermis following treatment.
Trelles, Mario A., et al. Lasers in Surgery and Medicine, 2014, 46(2), 152-159.
This work evaluated the efficacy of transdermal injection of a proprietary cosmetic formulation under acoustic pressure ultrasound guidance using high-power unipolar fractional ablative radiofrequency through the RF Pixel fractional microchannels for acne scar lightening.
· Cosmetic Formulation
A specific cosmetic formulation designed to treat scars was developed. This formulation includes molecules that possess keratolytic, whitening, and anti-inflammatory properties, along with liposome-encapsulated peptides that target collagen, matrix metalloproteinases (MMPs), and particular enzymes. Key ingredients in the formulation consist of allantoin, bisabolol, sodium hyaluronate, glycosaminoglycans, dipotassium glycyrrhizate, a vitamin B complex, vitamin C, and low molecular weight peptides (SH-polypeptide 15, Palmitoyl tripeptide 28, Tripeptide 8, and Oligopeptide 8).
· Evaluation Results
There was a significant enhancement in scarring on the face (P < 0.0001), and also on the back and shoulders (P < 0.0001). Two months after that, the total reduction of scarring was 57% on the face and 49% on the back and shoulders; after six months it increased to 62% on the face and 58% on the back and shoulders. Patient satisfaction included: Slightly Satisfied (16%), Satisfied (53%) and Very Satisfied (31%). No unexpected ablation-related side effects were observed or hypersensitivity to the cosmetic formulation.
What is Palmitoyl Tripeptide-28 and how does it work?
Palmitoyl Tripeptide-28 is a peptide ingredient that mimics the action of cytokines by binding to TGF beta receptor 2 on fibroblast membranes. This interaction stimulates the production of extracellular matrix (ECM) components, thereby enhancing skin's smoothness, firmness, and overall youthful appearance. It also inhibits metalloproteinases that degrade collagen, thus preserving skin integrity.
How does Palmitoyl Tripeptide-28 benefit the skin?
Palmitoyl Tripeptide-28 boosts the production of integrins, which are molecules that improve cell adhesion to the ECM. Additionally, it increases the synthesis of protease inhibitors, further enhancing collagen and elastin levels. These activities contribute to regenerating the ECM, which helps smooth, firm, and refresh the skin for a healthy and youthful appearance.
In which products can Palmitoyl Tripeptide-28 be typically found?
Palmitoyl Tripeptide-28 is used in peptide-based complexes such as Infinitec's ECM Moduline and Sapphire Lift. These products leverage its ability to foster ECM regeneration and inhibit collagen-degrading enzymes.
How does Palmitoyl Tripeptide-28 inhibit collagen degradation?
It inhibits the activity of metalloproteinases (MMPs), which are enzymes responsible for breaking down collagen. By preventing these enzymes from degrading collagen, Palmitoyl Tripeptide-28 helps maintain the skin's structural integrity and youthful appearance.
Can Palmitoyl Tripeptide-28 improve cell adhesion?
Yes, Palmitoyl Tripeptide-28 enhances the production of integrins, which are crucial for improving cell adhesion to the extracellular matrix. This increased adhesion supports the skin's structural stability and overall health.
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