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Palmitoyl hexapeptide

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Catalog Number	CI-BP-0014
Product Name	Palmitoyl hexapeptide
CAS	171263-26-6
Structure
Synonyms	Palmitoyl hexapeptide-12, N-(1-Oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolylglycine
IUPAC Name	2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-(hexadecanoylamino)-3-methylbutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetic acid
Molecular Weight	736.98 g/mol
Molecular Formula	C38H68N6O8
InChI	InChI=1S/C38H68N6O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-22-30(45)42-33(26(2)3)36(50)39-24-31(46)43-34(27(4)5)37(51)41-28(6)38(52)44-23-20-21-29(44)35(49)40-25-32(47)48/h26-29,33-34H,7-25H2,1-6H3,(H,39,50)(H,40,49)(H,41,51)(H,42,45)(H,43,46)(H,47,48)/t28-,29-,33-,34-/m0/s1
InChI Key	JFSQSDAOQLNSQI-DTBJPNGVSA-N
Boiling Point	1024.8±65.0 °C
Density	1.105 g/mL
Storage	Sealed in dry,Room Temperature
Isomeric SMILES	CCCCCCCCCCCCCCCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
pKa	3.67±0.10

Product Overview

Palmitoyl Hexapeptide is a synthetic lipo-peptide designed to enhance skin firmness and tone. As a derivative of the VGVAPG-peptide sequence, this peptide mimics a fragment of natural elastin, often referred to as a "spring fragment," which is repeated six times in elastin molecules. This structure consists of a peptide bound to lipophilic palmitic acid, enhancing its stability and facilitating penetration through the skin's lipid barrier. By leveraging the chemotactic properties of the VGVAPG sequence, Palmitoyl Hexapeptide stimulates fibroblast activity and mobility, promoting increased collagen and elastin production. This process aids in restructuring dermal layers, thus improving skin firmness and contributing to a more youthful appearance. It is particularly effective in applications aimed at firming the skin, contouring the eye area, and addressing concerns related to mature skin, as it works to smoothen the skin's surface and diminish the appearance of fine lines and wrinkles.

Custom Q&A

What is Palmitoyl Hexapeptide-12?

Palmitoyl Hexapeptide-12 is a synthetic lipo-peptide derived from the VGVAPG-peptide, which is a fragment of natural elastin. It combines a peptide sequence with lipophilic palmitic acid to enhance stability and penetration through the skin's lipid barrier.

What are the benefits of using Palmitoyl Hexapeptide-12 in skincare?

Palmitoyl Hexapeptide-12 helps to improve skin firmness and tone by stimulating collagen and elastin production. Its chemotactic properties enhance fibroblast activity and mobility, which aids in restructuring dermal tissues. It is effective in reducing fine lines and wrinkles, providing a more youthful appearance.

How does Palmitoyl Hexapeptide-12 work to enhance skin appearance?

It boosts dermal restructuration by facilitating cell communication. This action promotes increased production of collagen and elastin, essential proteins for maintaining the skin's firmness and elasticity, thereby smoothing the skin's surface and rejuvenating the overall appearance.

In what types of skincare products can Palmitoyl Hexapeptide-12 be found?

Palmitoyl Hexapeptide-12 is commonly used in products aimed at skin-firming, eye-contouring, and mature hand care. It is incorporated into various skincare applications to target and improve signs of aging and help maintain youthful and healthy-looking skin.

How does the structure of Palmitoyl Hexapeptide-12 enhance its effectiveness?

The structure of Palmitoyl Hexapeptide-12, which includes a peptide sequence attached to palmitic acid, improves its stability and binding ability to human skin. This structural characteristic facilitates more effective penetration through the skin's lipid barrier, optimizing its benefits for skincare applications.

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