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| Catalog Number | CI-BP-0074 |
| Product Name | PAL-KT |
| CAS | 911813-90-6 |
| Structure |  |
| Synonyms | Palmitoyl dipeptide-7 |
| IUPAC Name | (2S,3R)-2-[[(2S)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoic acid |
| Molecular Weight | 485.7 g/mol |
| Molecular Formula | C26H51N3O5 |
| InChI | InChI=1S/C26H51N3O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-23(31)28-22(18-16-17-20-27)25(32)29-24(21(2)30)26(33)34/h21-22,24,30H,3-20,27H2,1-2H3,(H,28,31)(H,29,32)(H,33,34)/t21-,22+,24+/m1/s1 |
| InChI Key | FGSPQNZCLMWQAS-GPXNEJASSA-N |
| Boiling Point | 722.8±60.0 °C |
| Purity | 0.95 |
| Density | 1.041 g/mL |
| Appearance | White powder |
| Storage | -15~-20 °C |
| Isomeric SMILES | CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)O |
| pKa | 3.25±0.10 |
| Safety | No heavy metals, no skin and eye irritation |
PAL-KT, also known as Palmitoyl Dipeptide-7, is a highly effective matrikine lipo-peptide utilized primarily for its anti-aging capabilities. As the shortest matrikine lipo-peptide, it bears a repeating sequence of palmitoyl-lysine-threonine, akin to the well-known Matrixyl™ pentapeptide (Pal-KTTKS), and demonstrates similar properties in stimulating the production of crucial extracellular matrix components, particularly collagen, by fibroblasts. Discovered through the peptide screening program conducted by Sederma and P&G Beauty Division, PAL-KT has shown superior efficacy when compared to other peptides tested in human-derived fibroblasts. Scientific assessments reveal that Palmitoyl Dipeptide-7 not only enhances the production of vital skin structural proteins, such as collagen and laminin, but also influences gene expression associated with wound healing and skin recovery. Moreover, it amplifies the effects of other anti-aging ingredients, such as Niacinamide, allowing the active ingredients to achieve optimal results even at minimal concentrations. When used in conjunction with Matrixyl™ in certain anti-aging formulations, it has demonstrated its ability to visibly firm, smooth, and rejuvenate the skin.
What is PAL-KT and what are its main benefits?
PAL-KT, also known as Palmitoyl Dipeptide-7, is a matrikine lipo-peptide known for its anti-aging properties. It mimics a part of the sequence from the well-known Matrixyl pentapeptide and stimulates the production of extracellular matrix (ECM) components, particularly collagen, by fibroblasts. This leads to improved skin firmness, smoothing, and rejuvenation.
How does PAL-KT compare to other peptides in terms of efficacy?
PAL-KT has been shown to have superior activity compared to other peptides tested in human-derived fibroblasts. Scientific tests have demonstrated its ability to increase the production of key structural skin proteins like collagen and laminin more effectively than some other peptides.
Can PAL-KT be used with other anti-aging ingredients?
Yes, PAL-KT can be combined with other anti-aging ingredients, such as Niacinamide. It works synergistically to enhance the effects of other actives, delivering optimal results even at minimal concentrations. Additionally, it is often used in conjunction with Matrixyl in various formulations to achieve noticeable firming and smoothing effects.
Does PAL-KT have any additional benefits aside from boosting collagen production?
Beyond boosting collagen production, studies suggest that PAL-KT affects the expression of genes involved in wound healing and skin recovery. This makes it an excellent ingredient for promoting overall skin health and recovery.
If you have any questions, please contact us. You will get a satisfactory answer.
