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| Catalog Number | CI-BP-0055 |
| Product Name | Oligopeptide-34 |
| Molecular Weight | 1467.57 g/mol |
| Molecular Formula | C64H94N18O22 |
| Purity | 0.95 |
| Appearance | White powder |
| Application | Whitening and brightening skin |
| Storage | -15~-20 °C |
| Safety | No heavy metals, no skin and eye irritation |
Oligopeptide-34, also known as CG-TGP2, is a synthetic peptide designed for use in skincare formulations targeting hyperpigmentation and anti-aging concerns. Its primary function is to inhibit melanin production by down-regulating key enzymes and proteins such as TRP-1, TRP-2, MITF, and Tyrosinase. Additionally, it prevents the assembly and transfer of melanosomes from melanocytes to keratinocytes, yielding a notable skin-brightening effect. By promoting the degradation of the melanocyte-stimulating hormone, Oligopeptide-34 further limits tyrosinase activity, crucial in the melanin synthesis process. Clinical studies have demonstrated that formulations containing Oligopeptide-34 significantly reduce melanin content and limit tyrosinase activity in melanocyte cultures, with its effects being dose-dependent. Additionally, this peptide exhibits anti-inflammatory properties by down-regulating pro-inflammatory cytokines, thereby reducing dermal lymphocyte proliferation. It also facilitates fibroblast differentiation and proliferation, which leads to increased levels of collagen, elastin, and fibronectin in the skin's extracellular matrix, enhancing overall skin integrity and appearance. As a result, Oligopeptide-34 serves as an effective and versatile ingredient in cosmetic applications aimed at reducing hyperpigmentation and supporting anti-aging benefits.
What is Oligopeptide-34 and how does it work?
Oligopeptide-34, known under the trade name CG-TGP2, is a synthetic peptide specifically designed to reduce melanin synthesis. It achieves this by down-regulating key enzymes and proteins involved in the melanin production process, such as TRP-1, TRP-2, MITF, and Tyrosinase. It also inhibits melanosome assembly and transfer, resulting in a significant skin-brightening effect.
How does Oligopeptide-34 affect melanin synthesis?
The peptide effectively decreases melanin synthesis by targeting and down-regulating enzymes like tyrosinase, which is pivotal in the melanin synthesis cascade. Additionally, it blocks melanosome assembly and transfer, preventing melanin from reaching the skin's surface and contributing to hyperpigmentation.
Can Oligopeptide-34 have anti-inflammatory effects?
Yes, Oligopeptide-34 is known for its anti-inflammatory properties. It down-regulates TH1-type pro-inflammatory cytokines, which reduces dermal lymphocyte cell proliferation, thereby delivering a noticeable anti-inflammatory effect.
What additional benefits does Oligopeptide-34 offer for skin health?
Aside from its skin-brightening and anti-inflammatory effects, Oligopeptide-34 promotes the division and differentiation of fibroblasts, which leads to an increase in collagen, elastin, and fibronectin levels in the skin's extracellular matrix (ECM). This supports skin's firmness and elasticity, making it an effective ingredient in anti-aging applications.
Is Oligopeptide-34 safe for use in skincare products?
Yes, Oligopeptide-34 is considered a multifunctional, safe, and effective ingredient suitable for use in preparations aimed at treating hyperpigmentation as well as anti-aging products. Its efficacy has been demonstrated in tests showing significant inhibition of melanin synthesis and decreased tyrosinase activity.
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