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Octapeptide-2

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Catalog Number	CI-BP-0166
Product Name	Octapeptide-2
CAS	1374396-34-5
Synonyms	L-Methionine, L-threonyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-histidyl-L-α-glutamyl-L-valyl-
IUPAC Name	(4S)-4-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]propanoyl]amino]-5-[[(2S)-4-carboxy-1-[[(2S)-1-[[(2S)-4-carboxy-1-[[(2S)-1-[[(1S)-1-carboxy-3-methylsulfanylpropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Molecular Weight	945.01 g/mol
Molecular Formula	C38H60N10O16S
InChI	InChI=1S/C38H60N10O16S/c1-17(2)30(37(62)46-24(38(63)64)12-13-65-5)48-34(59)23(8-11-28(54)55)45-35(60)25(14-20-15-40-16-41-20)47-33(58)22(7-10-27(52)53)44-32(57)21(6-9-26(50)51)43-31(56)18(3)42-36(61)29(39)19(4)49/h15-19,21-25,29-30,49H,6-14,39H2,1-5H3,(H,40,41)(H,42,61)(H,43,56)(H,44,57)(H,45,60)(H,46,62)(H,47,58)(H,48,59)(H,50,51)(H,52,53)(H,54,55)(H,63,64)/t18-,19+,21-,22-,23-,24-,25-,29-,30-/m0/s1
InChI Key	IZUXSDLDQJZDFW-BNJNSGOPSA-N
Boiling Point	1566.9±65.0 °C
Density	1.394 g/mL
Isomeric SMILES	C[C@H]([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)O)N)O
pKa	3.22±0.10

Product Overview

Octapeptide-2, also known commercially as Prohairlin-β4, is a synthetic peptide utilized in various premium haircare products to enhance hair strength and growth. By stimulating the development and activity of follicle stem cells, it effectively promotes hair growth and accelerates cell migration within hair follicles, while also preventing apoptosis. This action results in reinforced hair that boasts a healthy shine. Additionally, Octapeptide-2 works to inhibit protease production, contributing to the restoration of hair growth, and it actively stimulates the production of collagen, elastin, and fibronectin by fibroblasts. Compared to native proteins that boost hair growth, Prohairlin-β4 offers greater stability and extended effects, making it a popular choice in advanced hair growth-stimulating shampoos, masks, and serums.

Custom Q&A

What is Octapeptide-2 and how does it work?

Octapeptide-2 is a synthetic peptide known under the trade name Prohairlin-β4. It is designed to strengthen hair and promote its growth by boosting follicle stem cell development and activity. This peptide also accelerates cell migration within hair follicles and inhibits apoptosis, thereby reinforcing the hair structure and providing it with a healthy shine.

What are the key benefits of using Octapeptide-2 in hair care products?

The key benefits of using Octapeptide-2 include promoting hair growth, strengthening hair, and providing a healthy shine. It inhibits protease production, restores hair growth capabilities, and stimulates the synthesis of critical proteins such as collagen, elastin, and fibronectin by fibroblasts. These actions contribute to improved hair health and vitality.

How does Octapeptide-2 compare to native hair-boosting proteins?

In comparison to native hair-boosting proteins, Prohairlin-β4, the form of Octapeptide-2 used in products, is more stable and exhibits prolonged action. This enhanced stability allows it to provide sustained benefits in promoting hair growth and improving hair strength over time.

In what types of products is Octapeptide-2 commonly found?

Octapeptide-2 is commonly incorporated into high-end hair growth-stimulating shampoos, masks, and serums. These products leverage the peptide's ability to enhance hair strength and growth, making them popular choices for individuals seeking advanced hair care solutions.

How does Octapeptide-2 contribute to overall hair health?

Octapeptide-2 contributes to overall hair health by strengthening hair follicles, preventing cell apoptosis, and encouraging the natural process of protein synthesis. This leads to healthier, more resilient hair that exhibits improved growth, shine, and resistance to damage.

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