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| Catalog Number | CI-SC-0564 |
| Product Name | Niacin |
| CAS | 59-67-6 |
| Structure |  |
| Synonyms | 3-Pyridinecarboxylic acid;Nicotinic acid |
| Description | Niacin, also known as vitamin B3, is an essential water-soluble vitamin that plays a crucial role in the body's metabolism. It is needed by the body to convert carbohydrates, fats, and proteins into energy. Niacin is also important for maintaining healthy skin, nerves, and digestion. There are two forms of niacin: nicotinic acid and nicotinamide. Nicotinic acid is often used as a dietary supplement to lower cholesterol levels, while nicotinamide is used in skin creams to treat acne and other skin conditions. |
| IUPAC Name | Pyridine-3-carboxylic acid |
| Molecular Weight | 123.11 g/mol |
| Molecular Formula | C6H5NO2 |
| Canonical SMILES | C1=CC(=CN=C1)C(=O)O |
| InChI | PVNIIMVLHYAWGP-UHFFFAOYSA-N |
| InChI Key | InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9) |
| Melting Point | 236-239 °C(lit.) |
| Density | 1.473 g/mL |
| Appearance | white, crystalline powder or as small colorless or yellowish crystals |
| Application | 1. Niacin is used to treat niacin deficiency and related conditions such as Pellagra. 2. It is also used as a dietary supplement to reduce cholesterol and in the prevention and treatment of cardiovascular diseases. 3. Niacin has also been shown to help lower blood pressure, and improve brain function and skin health. 4. In addition, it is used as a coenzyme in energy production and metabolism in the body. 5. Topically, niacin can also be used to treat acne and improve skin texture. |
| Features And Benefits | 1. Helps to reduce hyperpigmentation 2. Improves skin texture and tone 3. Acts as an antioxidant 4. Boosts collagen production 5. Increases skin hydration 6. Reduces inflammation and acne 7. Enhances barrier function of the skin 8. Increases skin elasticity. |
Niacin, also known as Vitamin B3, is a highly regarded component in skincare known for its ability to easily penetrate the stratum corneum and deliver numerous skin benefits. It is frequently utilized in cosmetics due to its effectiveness in improving the skin's barrier function thereby reducing transepidermal water loss and increasing moisture retention. Furthermore, niacin promotes the synthesis of free fatty acids and ceramides in the skin aiding in the treatment of conditions such as atopic dermatitis. This versatile ingredient also enhances collagen and keratin protein production, contributing to its use in skin brightening by inhibiting melanosome transfer. Additionally, niacin supports skin immunity by enhancing the function of Langerhans cells and assists in regulating sebum production.
What are the key benefits of using Niacin (Vitamin B3) in skincare?
Niacin, or Vitamin B3, offers multiple benefits for the skin. It penetrates easily into the stratum corneum and helps improve skin barrier function by stabilizing the epidermis, thus reducing transepidermal water loss and enhancing moisture content. Additionally, it boosts the synthesis of free fatty acids and ceramides, which further improves skin hydration. Dermatologists recommend it for conditions like atopic dermatitis. Niacin also aids in increasing collagen and keratin production, providing a brightening effect by inhibiting melanosome transfer, and boosting skin immunity through enhanced Langerhans cell function. It can also help in regulating sebum production.
How does Niacin help in treating atopic dermatitis?
Niacin is effective in treating atopic dermatitis because it stabilizes the barrier function of the epidermis. This reduces transepidermal water loss and improves the skin's moisture balance. By increasing the synthesis of free fatty acids and ceramides in the stratum corneum, Niacin strengthens the skin barrier, making it less prone to irritation and inflammation commonly observed in atopic dermatitis.
Can Niacin be used to improve skin brightness?
Yes, Niacin can be used to improve skin brightness. It inhibits the transfer of melanosomes from melanocytes to keratinocytes, which helps in reducing hyperpigmentation and achieving a more even skin tone. This brightening effect makes Niacin a popular choice in cosmetic products aimed at enhancing skin radiance.
In what ways does Niacin help improve the skin's moisture content?
Niacin enhances the moisture content of the skin by stabilizing the epidermal barrier and reducing transepidermal water loss. It also increases the synthesis of free fatty acids and ceramides, crucial components that help maintain hydration levels in the stratum corneum. This results in softer, more hydrated skin.
Is Niacin suitable for oily skin types?
Yes, Niacin is suitable for oily skin types as it assists in the down-regulation of sebum production. By balancing sebum levels, Niacin can help reduce the occurrence of acne and keep oily skin looking healthier. Its ability to improve skin barrier function without clogging pores further adds to its suitability for oily skin.
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