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Melanostatine-5

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Catalog Number	CI-BP-0045
Product Name	Melanostatine-5
CAS	158563-45-2
Structure
Synonyms	Nonpeptide-1
IUPAC Name	(2S)-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-1-[(2S)-2-amino-4-methylsulfanylbutanoyl]pyrrolidine-2-carboxamide
Molecular Weight	1206.5 g/mol
Molecular Formula	C61H87N15O9S
InChI	InChI=1S/C61H87N15O9S/c1-37(2)51(52(64)77)74-58(83)50-26-16-31-76(50)60(85)45(23-12-13-28-62)70-55(80)46(33-38-17-6-4-7-18-38)71-56(81)48(35-40-36-68-43-22-11-10-21-41(40)43)72-53(78)44(24-14-29-67-61(65)66)69-54(79)47(34-39-19-8-5-9-20-39)73-57(82)49-25-15-30-75(49)59(84)42(63)27-32-86-3/h4-11,17-22,36-37,42,44-51,68H,12-16,23-35,62-63H2,1-3H3,(H2,64,77)(H,69,79)(H,70,80)(H,71,81)(H,72,78)(H,73,82)(H,74,83)(H4,65,66,67)/t42-,44-,45-,46-,47+,48+,49-,50-,51-/m0/s1
InChI Key	KNFLNGRLKALWRF-LDXSYGEZSA-N
Purity	0.95
Density	1.38 g/mL
Appearance	White or off-white powder
Isomeric SMILES	CC(C)[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CC5=CC=CC=C5)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCSC)N

Product Overview

Melanostatine-5, also known as Nonapeptide-1, is a synthetic peptide designed to mimic biological processes by antagonizing the α-melanocyte-stimulating hormone (α-MSH). Through an advanced screening technique that tested various segments of the α-MSH sequence, Nonapeptide-1 was identified for its capacity to occupy and block MC1-R receptors on melanocytes. By preventing the receptor activation by α-MSH, Melanostatine-5 effectively reduces melanin production by 33% by inhibiting the action of tyrosinase, a critical enzyme in melanin synthesis. This selective inhibition makes Melanostatine-5 an excellent candidate for skin-lightening applications, as it reduces hyperpigmentation without affecting melanocyte health or function. Its use in skincare products helps diminish sunspots, dark patches, freckles, and overall hyperpigmentation, thereby promoting a more uniform and luminous complexion. Furthermore, Melanostatine-5 is recognized for its stability, efficacy, and safety, capable of significantly improving skin tone uniformity within 28 days.

Custom Q&A

What is Melanostatine-5 and how does it work?

Melanostatine-5, also known as Nonapeptide-1, is a synthetic biomimetic peptide designed to reduce melanin production in the skin. It functions as an antagonist to the α-MSH (melanin-stimulating hormone), blocking the hormone from activating MC1-R receptors on melanocytes, which are cells responsible for melanin production. By inhibiting these receptors, Melanostatine-5 effectively lessens melanin synthesis by around 33%, contributing to a lighter skin tone.

How does Melanostatine-5 affect skin pigmentation?

By preventing the activation of tyrosinase, a key enzyme in melanin synthesis, Melanostatine-5 helps manage hyperpigmentation. It does not completely stop the production of melanin, which means it helps moderate the excess production of melanin that leads to pigmentation issues such as dark spots, sun spots, freckles, and uneven skin tone.

Is Melanostatine-5 safe for use in skincare products?

Yes, Melanostatine-5 is considered safe for use in skincare applications. It does not exhibit cytotoxicity nor does it interfere with the natural functions of melanocytes. This makes it an effective and safe choice for those seeking to improve skin tone and reduce hyperpigmentation.

What results can I expect from using products containing Melanostatine-5?

Products containing Melanostatine-5 are designed to reduce pigmentation issues, resulting in a brighter and more even skin tone. Users may observe a noticeable reduction in hyperpigmentation, sun and dark spots, and an overall lighter complexion within approximately 28 days of consistent use.

How stable is Melanostatine-5 in skincare formulations?

Melanostatine-5 is a stable peptide, ensuring its effectiveness in skincare products. Its stability contributes to the reliable performance of these products in reducing pigmentation and achieving a uniform skin tone.

Does Melanostatine-5 inhibit normal melanin production?

No, Melanostatine-5 does not completely inhibit normal melanin production. It interacts selectively to moderate the overproduction of melanin, allowing for a balance between reducing hyperpigmentation and maintaining essential skin functions.

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