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| Catalog Number | CI-OT-0044 |
| Product Name | Ergothioneine |
| CAS | 497-30-3 |
| Structure |  |
| Synonyms | 1H-Imidazole-4-ethanaminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, hydroxide, inner salt, (S)- |
| IUPAC Name | (2S)-3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)-2-(trimethylazaniumyl)propanoate |
| Molecular Weight | 229.3 g/mol |
| Molecular Formula | C9H15N3O2S |
| InChI | InChI=1S/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/m0/s1 |
| InChI Key | SSISHJJTAXXQAX-ZETCQYMHSA-N |
| Melting Point | 275-277 °C |
| Purity | 95% |
| Density | 1.25 g/mL |
| Solubility | Soluble in Water |
| Appearance | Solid |
| Highest Usage In Residency Products | 0.075 |
| Isomeric SMILES | C[N+](C)(C)[C@@H](CC1=CNC(=S)N1)C(=O)[O-] |
Ergothioneine, known as thiotaine, is a versatile amino acid incorporated into anti-aging formulations, boasting excellent dermatological acceptance. Naturally present in the body and identified through the OCTN-1 transporter in dermal fibroblasts, this substance is a remarkably stable, colorless, and odorless antioxidant. Ergothioneine surpasses the capabilities of ubiquinone (Coenzyme Q10) as a radical scavenger. Similar to L-Carnitine, it serves as an effective skin energizer. Additionally, it possesses anti-inflammatory properties and protects against collagen and elastin degradation by inhibiting UVA-induced stress factors, including MMP-1, which directly degrades collagen. Ergothioneine also functions as an elastase inhibitor via the protective action of the qAP-1 enzyme and helps prevent UV-A induced DNA damage.
What are the primary cosmetic benefits of using Ergothioneine in skincare products?
Ergothioneine is a powerful natural antioxidant comparable to vitamin C in combating free radicals. It plays a critical role in protecting the skin from oxidative stress and environmental damage. This amino acid helps to preserve skin's firmness and elasticity by inhibiting the collagen-destroying enzyme MMP-1. Additionally, Ergothioneine improves skin brightness and reduces hyperpigmentation by inhibiting tyrosinase, an enzyme responsible for melanin production.
How does Ergothioneine contribute to skin revitalization and energy production?
Ergothioneine has a structure similar to that of essential Carnitine, which is instrumental in transporting fatty acids into mitochondria for energy production. This characteristic allows Ergothioneine to boost ATP (energy) production and enhance fat metabolism. As a result, it revitalizes skin cells, giving the skin a rejuvenated and radiant appearance.
Is Ergothioneine effective in anti-aging skincare formulations?
Yes, Ergothioneine is an ideal ingredient for anti-aging skincare products. It offers multiple benefits, such as protecting against free radical damage, preserving structural fibers in the skin, and inhibiting enzymes that lead to collagen breakdown. These actions collectively help in slowing down the skin's aging process and maintaining a youthful appearance.
Can Ergothioneine help with hyperpigmentation and dark spots?
Ergothioneine is effective in lightening hyperpigmentation and reducing dark spots. It inhibits the activity of tyrosinase, an enzyme crucial to melanin production, resulting in a whitening effect on the skin and the elimination of dark spots, contributing to a more even skin tone.
How does Ergothioneine protect the skin from environmental pollutants?
Ergothioneine functions as a potent chelator agent, similar to Kojic acid, by binding with heavy metal ions. This ability helps guard the skin against harmful environmental pollutants and toxins, further supporting skin health and resilience.
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